Discovery of diaminobutane derivatives as Ca2+ -permeable AMPA receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 5, 2002, Pages 1347-1359

  Yoneda, Yoshiyuki ^b   Mimura, Tetuya ^a   Kawagoe, Keiichi ^a   Yasukouchi, Takanori ^a   Tatematu, Toshiaki ^a   Ito, Masayuki ^a   Saito, Masaki ^a   Sugimura, Masunobu ^a   Kito, Fusako ^a   Kawajiri, Shinichi ^a  

^a DAIICHI SANKYO CO   (Japan)

^b Tel: +81 3 3680 0151 ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR ANTAGONIST; BUTANE; CALCIUM ION; N CYCLOHEXYLMETHYL N' [1 (1 NAPHTHYLACETYL)PIPERIDIN 4 YLMETHYL] 1,4 DIAMINOBUTANE; UNCLASSIFIED DRUG; AMPA RECEPTOR; CALCIUM; DIAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NEUROPROTECTION; NONHUMAN; RAT; ANIMAL; BLOOD PRESSURE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GERBIL; METABOLISM; NERVE CELL; OOCYTE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRANSIENT ISCHEMIC ATTACK; TRANSPORT AT THE CELLULAR LEVEL; XENOPUS;

GERBILLINAE;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD PRESSURE; CALCIUM; DIAMINES; DISEASE MODELS, ANIMAL; GERBILLINAE; ISCHEMIC ATTACK, TRANSIENT; NEURONS; OOCYTES; RATS; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 18344382337     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00398-4     Document Type: Article

References (36)