Synergistic effects of tocopherol, tocotrienol, and ubiquinone in indomethacin-induced experimental gastric lesions

International Journal for Vitamin and Nutrition Research

Volumn 75, Issue 2, 2005, Pages 149-155

  Nafeeza, M I ^a   Kang, T T ^a  

^a DEPARTMENT OF PHARMACOLOGY   (Malaysia)

Author keywords

Gastric lesions; Indomethacin; Tocopherol; Tocotrienol; Ubiquinone

Indexed keywords

ALPHA TOCOTRIENOL; GLUTATHIONE; INDOMETACIN; PROSTAGLANDIN E2; TOCOPHEROL; UBIQUINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; LIPID PEROXIDATION; MALE; NONHUMAN; PARAMETER; RAT; STOMACH ACID; STOMACH LESION;

ANIMALS; ANTIOXIDANTS; DINOPROSTONE; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; GASTRIC ACID; GLUTATHIONE; INDOMETHACIN; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; STOMACH DISEASES; TOCOPHEROLS; TOCOTRIENOLS; UBIQUINONE;

EID: 18344382151     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.75.2.149     Document Type: Article

References (46)

1. Cappell, M. and Schein, J. R. (2000) High-risk, underappreciated, observe or preventable cause of gastrointestinal bleeding: Diagnosis and treatment of nonsteroidal anti-inflammatory drug-associated upper gastrointestinal toxicity. Gastroenterol. Clin. North Am. 29 (1), 97-124.
2. Kawano, S., Tsnji, S. and Sato, N. (1996) NSAIDs and the microcirculation of the stomach. Gastroenterol. Clin. North Am. 25, 299-315.
3. Armstrong, C. P. and Blower, A. L. (1987) Non-steroidal anti-inflammatory drugs and life-threatening complications of peptic ulceration. Gut 28, 527-532.
4. Goldstein, J. L., Larson, L. R. and Yamashita, B. D. (1997) Management of NSAID-induced gastropathy: An economic decision analysis. Clin. Ther. 19, 1496-1509.
5. Griffin, M. R. (1998) Epidemiology of nonsteroidal anti-inflammatory drug-associated gastrointestinal injury. Am. J. Med. 104, 235-295.
6. Hawkey, C. J. (1997) The gastroenterologist's caseload: Contribution of the rheumatologist. Semin. Arthritis Rheum. 26, 11-15.
7. Sontag, S. J., Schnell, T. G., Budiman-Mak, E., et al (1994) Healing of NSAID-induced gastric ulcers with a synthetic prostaglandin analog (Enprostil). Am. J. Gastroenterology 89, 1014-1020.
8. Taha, A. S., Hudson, N., Hawkey, C. J., et al (1996) Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. New England J. Medicine 334, 1435-1439.
9. Hawkey, C. J., Karrazch, J. A., Szczepanski, L., et al (1998) Omeprazole compared with misoprostol for ulcer associated with nonsteroidal antiinflammatory drugs. New England J. Medicine 338, 727-734.
10. Davies, N. M. and Wallance, J. L. (1997) Nonsteroidal anti-inflammatory drug induced gastrointestinal toxicity: New insights into an old problem. J. Gastroenterology 32, 127-133.
11. Granger, D. N., Hernandez, L. A. and Grisham, M. B. (1986) Reactive oxygen metabolite: Mediators of cell injury in digestive system. Viewpoint Dig. Dis. 1813-1817.
12. Kamsiah, J., Renuvathani, M., Nafeeza, M.I. and Gapor, M.T. (1999) Comparative effect of palm vitamin E and ranitidine on the healing of ethanol-induced gastric lesions in rats. Int. J. Ext. Path. 80, 259-263.
13. Nafeeza, M. I., Kamsiah, J., Aminuddin, A., Alini, M., Ng, W. K. and Gapor, M.T. (1999) Palm vitamin E and healing of ethanol-induced gastric lesions. Asia Pacific J. Clin. Nutr. 8(4), 258-262.
14. Naito, Y., Yoshikawa, T., Kaneko, T., Iinuma, S., Nishimura, S., Takahashi, S. and Kondo, M. (1993) Role of oxygen radical in indomethacin-induced gastric mucosal microvascular injury in rats. J. Clin. Gastroenterol. 17, S99-S103.
15. Yoshikawa, T., Naito, Y., Nakamura, S., Nishimura, S., Kaneko, T., Iinuma, S., Takahashi, T. and Kondo, M. (1993) Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indomethacine in rats. Arzneim Forsch. 43, 1327-1330.
16. Nafeeza, M. I., Fauzee, A. M., Kamsiah, J. and Gapor, M.T. (2002) Comparative effects of tocotrienol-rich fraction and tocopherol in aspirin induced gastric lesions in rats. Asia Pac. J. Clin. Nutr. 11 (4), 309-311.
17. Rainsford, K. D. (1983) Microvascular injury during gastric mucosal damage by antiinflammatory drugs in pigs and rats. Agents Actions 13, 5-6.
18. Schoenberg, M., Muhl, E., Sellin, D., Younes, M., Schildberg, (init.?) and Hagluno, V. (1984) Posthypertensive generation of superoxide free radicals - possible role on the pathogenesis of the intestinal mucosal damage. Act. Clin. Scan. 150, 301-309.
19. 2 inhibitor therapy. Surgery 113, 183-191.
20. Tariq, M. and Aqeel, A. M. (1990) Gastric ulcer and cytoprotective effects of dipyridamole in rats. J. Pharmacol. Exp. Ther. 253, 946-949.
21. 2 and oxygenated free radicals in mucosal damage after small intestinal ischaemia and reperfusion. Am. J. Surg. 157, 562-565.
22. Kosower, N. S. and Kosower, E. M. (1978) The glutathione status of cells. Int. Per. Cytol. 54, 109-160.
23. Boyd, S. C., Sasame, H. A. and Boyd, M. K. (1979) High concentration of glutathione in glandular stomach, possible implication for carcinogenesis. Science 205, 1010-1012.
24. Tariq, M. (1998) Gastric anti-ulcer and cytoprotective effect of vitamin E in rats. Res. Commun. Chem. Pathol. Pharmacol. 60, 87-96.
25. Wang, X. and Quinn, P. J. (1999) Vitamin E and its function in membranes. Prog. Lipid Res. 38 (4), 309-336.
26. Serbinova, E. A. and Packer, L. (1994) Antioxidant and biological activities of palm vitamin E. Food and Nutrition Bull. 15, 138-143.
27. 10: Alternative Therapies. American J. of Health-System Pharmacy 56 (6), 519-521.
28. Hassan, A. (1998) Role of antioxidants in gastric mucosal damage induced by indomethacin in rats. Methods and Findings in Experimental and Clinical Pharmacology 20 (10), 849-854.
29. Shay, H., David, C. H. and Gruenstein, M. (1954) A quantitative method for measuring spontaneous gastric acid secretion in rat. Gastroenterology 26 (6), 906-913.
30. Berry, C. N., Prouteau, M. and Lloyd, K. G. (1988) Sulphasalazine and PhCe 28a inhibit the formation of ethanol and phenylbutazone-induced rat gastric ulcer; lack of involvement of endogenous prostaglandin. Br. J. Pharmacol. 93, 465-472.
31. Ohkawa, H., Ohishi, N. and Yagi, K. (1979) Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358.
32. Griffith, O.W. (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106, 207-212.
33. Pihan, G., Regillo, C. and Szabo, S. (1987) Free radicals and lipid peroxidation in ethanol or aspirin-induced gastric mucosal injury. Dig. Dis. Sci. 32, 1395-1401.
34. Naito, Y., Yoshikawa, T., Matsuyama, K., Nishimura, S., Yagi, N. and Kondo, M. (1995) Effects of free radical scavengers on indomethacin-induced aggravation of gastric ulcer in rats. Dig. Dis. Sci. 40, 2019-2021.
35. Murakami, K. (1998) Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats. Dig. Dis. Sci. 43(9 Suppl), 139S-142S.
36. Son, M. (1996) Protective effect of taurine on indomethacin-induced gastric mucosal injury. Advances in Experimental Medicine and Biology 403, 147-155.
37. Alarcon, L. C. (1999) Protective effect of melatonin on indomethacin-induced gastric injury in rats. J. Pineal Research 26 (2), 101-107.
38. Maguire, J. J., Wilson, P. S. and Packer, L. (1989) Mitochondrial electron transport-linked tocopheroxyl radical reduction. J. Biol. Chem. 264 (36), 21462-21465.
39. Kagan, V., Scrbinova, E. and Packer, L. (1990) Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem. Biophys. Res. Commun. 169 (3), 851-857.
40. Canturk, N. Z., Canturk, Z. and Utkan, N. Z. (1999) The protective effect of vitamin E on gastric mucosal injury in rats with cirrhosis of liver. Clin. Med. J. (Engl) 112 (1), 56-60.
41. Takeuchi, K., Okada, M., Niida, H. and Okabe, S. (1989) Role of sulfhydryls in mucosal injury caused by ethanol: Relation to microvascular permeability, gastric motility and cytoprotection. J. Pharmacol. Exp. Ther. 248 (2), 836-841.
42. Smith, G. S., Tornwall, M. S., Barreto, J. C. and Miller, T. A. (1996) Gastric injury and protection against alcohol and acid: Influence of perturbations in glutathione metabolism. J. Surg. Res. 61 (2), 395-403.
43. Ghanayem, B. I., Ahmed, A. E. and Boor, P. J. (1984) Acetyl salicylic acid-induced gastric mucosal lesions: No role of gastric glutathione. Res. Commun. Chem. Pathol. Pharmacol. 45 (1), 153-156.
44. Ueshim, K., Takeuchi, K. and Okabe, S. (1992) Effects of sulfhydryl-related compounds on indomethacin-induced gastric lesions in rats: Role of endogenous sulfhydryls in the pathogenesis. Jpn. J. Pharmacol. 58 (2), 157-165.
45. 2. Prostaglandins 30 (4), 609-618.
46. Qodriyah, H. M. S., Normadiah, M. K., Gapor, M.T. and Nafeeza, M. I. (2002) Tocotrienol-rich fraction and its effects on parameters affecting gastric mucosa integrity after a single exposure to indomethacin. Pakistan J. Nutrition 1 (2), 89-92.