A soluble recombinant multimeric anti-Rh(D) single-chain Fv/CR1 molecule restores the immune complex binding ability of CR1-deficient erythrocytes

Journal of Immunology

Volumn 164, Issue 3, 2000, Pages 1505-1513

  Oudin, S ^a   Libyh, M Tonye ^a   Goossens, D ^b   Dervillez, X ^a   Philbert, F ^a   Reveil B ^a   Bougy, F ^a   Tabary, T ^a   Rouger, P ^b   Klatzmann, D ^c   Cohen, J H M ^a,d  

^a REIMS UNIVERSITY HOSPITAL   (France)

^b INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE   (France)

^c Unit of Dermatology   (France)

^d SERVICE DE DERMATOLOGIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B RECEPTOR; MEMBRANE PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; COMPLEMENT ACTIVATION; ERYTHROCYTE MEMBRANE; HEMOLYTIC ANEMIA; HUMAN; HUMAN CELL; IMMUNE COMPLEX DISEASE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 18244424748     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.3.1505     Document Type: Article

References (54)

1. Fearon, D. T. 1980. Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte. J. Exp. Med. 152:20.
2. Wilson, J. G., T. F. Tedder, and D. T. Fearon. 1983. Characterization of human T lymphocytes that express the C3b receptor. J. Immunol. 131:684.
3. Cornacoff, J. B., L. A. Hebert, W. L. Smead, M. E. VanAman, D. J. Birmingham, and F. J. Waxman. 1983. Primate erythrocyte-immune complex-clearing mechanism. J. Clin. Invest. 71:236.
4. Horgan, C., and R. P. Taylor. 1984. Studies on the kinetics of binding of complement-fixing dsDNA/anti-dsDNA immune complexes to the red blood cells of normal individuals and patients with systemic lupus erythematosus. Arthritis Rheum. 27:320.
5. Wilson, J. G., E. E. Murphy, W. W. Wong, L. B. Klickstein, J. H. Weis, and D. T. Fearon. 1986. Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes. J. Exp. Med. 164:50.
6. Paccaud, J. P., J. L. Carpentier, and J. A. Schifferli. 1988. Direct evidence for the clustered nature of complement receptors type 1 on the erythrocyte membrane. J. Immunol. 141:3889.
7. Medof, M. E., K. Iida, C. Mold, and V. Nussenzweig. 1982. Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes. J. Exp. Med. 156:1739.
8. Ripoche, J., and R. B. Sim. 1986. Loss of complement receptor type 1 (CR1) on ageing of erythrocytes. Studies of proteolytic release of the receptor. Biochem. J. 235:815.
9. Iida, K., R. Mornaghi, and V. Nussenzweig. 1982. Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus. J. Exp. Med. 155:1427.
10. Miyakawa, Y., A. Yamada, K. Kosaka, F. Tsuda, E. Kosugi, and M. Mayumi. 1981. Defective immune-adherence (C3b) receptor on erythrocytes from patients with systemic lupus erythematosus. Lancet 2:493.
11. Pangburn, M. K., R. D. Schreiber, and H. J. Muller-Eberhard. 1983. Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria. Proc. Natl. Acad. Sci. USA 80:5430.
12. Tausk, F. A., A. McCutchan, P. Spechko, R. D. Schreiber, and I. Gigli. 1986. Altered erythrocyte C3b receptor expression, immune complexes, and complement activation in homosexual men in varying risk groups for acquired immune deficiency syndrome. J. Clin. Invest. 78:977.
13. Cohen, J. H., C. Geffriaud, V. Caudwell, and M. D. Kazatchkine. 1989. Genetic analysis of CR1 (the C3b complement receptor, CD35) expression on erythrocytes of HIV-infected individuals. AIDS 3:397.
14. Birmingham, D. J., X. P. Shen, J. A. Hartman, J. J. Dillon, and L. A. Hebert. 1996. Effect of chronic human recombinant erythropoietin therapy on antibody responses to immunization in chronic hemodialysis patients. Kidney Int. 50:543.
15. Edberg, J. C., E. Wright, and R. P. Taylor. 1987. Quantitative analyses of the binding of soluble complement-fixing antibody/dsDNA immune complexes to CR1 on human red blood cells. J. Immunol. 139:3739.
16. Sim, R. B. 1985. Large-scale isolation of complement receptor type 1 (CR1) from human erythrocytes: proteolytic fragmentation studies. Biochem. J. 232:883.
17. Hebert, L. A., D. J. Birmingham, J. D. Mahan, X. P. Shen, C. McAllister, F. G. Cosio, and J. J. Dillon. 1994. Effect of chronically increased erythrocyte complement receptors on immune complex nephritis. Kidney Int. 45:493.
18. Taylor, R. P., E. N. Martin, M. L. Reinagel, A. Nardin, M. Craig, Q. Choice, R. Schlimgen, S. Greenbaum, N. L. Incardona, and H. D. Ochs. 1997. Bispecific monoclonal antibody complexes facilitate erythrocyte binding and liver clearance of a prototype particulate pathogen in a monkey model. J. Immunol. 159:4035.
19. Taylor, R. P., P. J. Ferguson, E. N. Martin, J. Cooke, K. L. Greene, K. Grinspun, M. Guttman, and S. Kuhn. 1997. Immune complexes bound to the primate erythrocyte complement receptor (CR1) via anti-CR1 mabs are cleared simultaneously with loss of CR1 in a concerted reaction in a rhesus monkey model. Clin. Immunol. Immunopathol. 82:49.
20. Weisman, H. F., T. Bartow, M. K. Leppo, H. C. Marsh, Jr., G. R. Carson, M. F. Concino, M. P. Boyle, K. H. Roux, M. L. Weisfeldt, and D. T. Fearon. 1990. Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 249:146.
21. Lucchesi, B. R., and K. S. Kilgore. 1997. Complement inhibitors in myocardial ischemia/reperfusion injury. Immunopharmacology 38:27.
22. Pruitt, S. K., W. M. Baldwin III, H. C. Marsh, Jr., S. S. Lin, C. G. Yeh, and R. R. Bollinger. 1991. The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. Transplantation 52:868.
23. Pruitt, S. K., and R. R. Bollinger. 1991. The effect of soluble complement receptor type 1 on hyperacute allograft rejection. J. Surg. Res. 50:350.
24. Landolfi, N. F. 1991. A chimeric Il-2/Ig molecule possesses the functional activity of both proteins. J. Immunol. 146:915.
25. Smith, R. I., M. J. Coloma, and S. L. Morrison. 1995. Addition of a μ-tailpiece to IgG results in polymeric antibodies with enhanced effector functions including complement-mediated cytolysis by igg4. J. Immunol. 154:2226.
26. de Kruif, J., and T. Logtenberg. 1996. Leucine zipper dimerized bivalent and bispecific scFv antibodies from a semi-synthetic antibody phage display library. J. Biol. Chem. 271:7630.
27. Francis, G. E., D. Fisher, C. Delgado, F. Malik, A. Gardiner, and D. Neale. 1998. Pegylation of cytokincs and other therapeutic proteins and peptides: the importance of biological optimisation of coupling techniques. Int. J. Hematol. 68:1.
28. Holliger, P., T. Prospero, and G. Winter. 1993. "Diabodies:" small bivalent and bispecific antibody fragments. Proc. Natl. Acad. Sci. USA 90:6444.
29. Dubel, S., F. Breitling, R. Kontermann, T. Schmidt, A. Skerra, and M. Little. 1995. Bifunctional and multimeric complexes of streptavidin fused to single chain antibodies (scFv). J. Immunol. Methods 178:201.
30. Smith, G. 1998. Patch engineering: a general approach for creating proteins that have new binding activities. Trends Biochem. Sci. 23:457.
31. Dahlback, B., C. A. Smith, and H. J. Muller-Eberhard. 1983. Visualization of human C4b-binding protein and its complexes with vitamin k-dependent protein s and complement protein C4b. Proc. Natl. Acad. Sci. USA 80:3461.
32. Villoutreix, B. O., Y. Hardig, A. Wallqvist, D. G. Covell, P. Garcia De Frutos, and B. Dahlback. 1998. Structural investigation of C4b-binding protein by molecular modeling: localization of putative binding sites. Proteins 31:391.
33. Criado Garcia, O., P. Sanchez-Corral, and S. Rodriguez de Cordoba. 1995. Isoforms of human C4b-binding protein. II. Differential modulation of the C4bpa and C4bpb genes by acute phase cytokines. J. Immunol. 155:4037.
34. Libyh, M. T., D. Goossens, S. Oudin, N. Gupta, X. Dervillez, G. Juszczak, P. Cornillet, F. Bougy, B. Reveil, F. Philbert, et al. 1997. A recombinant human scFv anti-rh(d) antibody with multiple valences using a c-terminal fragment of C4-binding protein. Blood 90:3978.
35. Goossens, D., F. Champomier, P. Rouger, and C. Salmon. 1987. Human monoclonal antibodies against blood group antigens: preparation of a series of stable ebv immortalized B clones producing high levels of antibody of different isolypes and specificities. J. Immunol. Methods 101:193.
36. Marks, J. D., H. R. Hoogenboom, T. P. Bonnert, J. McCafferty, A. D. Griffiths, and G. Winter. 1991. By-passing immunization: human antibodies from v-gene libraries displayed on phage. J. Mol. Biol. 222:581.
37. Marks, J. D., M. Tristem, A. Karpas, and G. Winter. 1991. Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific Oligonucleotide probes. Eur. J. Immunol. 21:985.
38. Hoogenboom, H. R., A. D. Griffiths, K. S. Johnson, D. J. Chiswell, P. Hudson, and G. Winter. 1991. Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res. 19:4133.
39. Steinbuch, M., and R. Audran. 1969. The isolation of IgG from mammalian sera with the aid of caprylic acid. Arch. Biochem. Biophys. 134:279.
40. Cohen, J. H., J. P. Aubry, M. H. Jouvin, J. Wijdenes, J. Bancherau, M. Kazatchkine, and J. P. Revillard. 1987. Enumeration of CR1 complement receptors on erythrocytes using a new method for detecting low density cell surface antigens by flow cytometry. J. Immunol. Methods 99:53.
41. Hunter, W. M., and F. C. Greenwood. 1964. A radio-immunoelectrophoretic assay for human growth hormone. Biochem. J. 91:43.
42. Chu, G., and P. A. Sharp. 1981. Sv40 DNA transfection of cells in suspension: analysis of efficiency of transcription and translation of t-antigen. Gene 13:197.
43. Davies, K. A., K. Erlendsson, H. L. Beynon, A. M. Peters, K. Steinsson, H. Valdimarsson, and M. J. Walport. 1983. Splenic uptake of immune complexes in man is complement-dependent. J. Immunol. 151:3866.
44. Medof, M. E., T. Lam, G. M. Prince, and C. Mold. 1983. Requirement for human red blood cells in inactivation of C3b in immune complexes and enhancement of binding to spleen cells. J. Immunol. 130:1336.
45. Schifferli, J. A., Y. C. Ng, and D. K. Peters. 1986. The role of complement and its receptor in the elimination of immune complexes. N. Engl. J. Med. 315:488.
46. Atkinson, J. P. 1989. Complement deficiency: predisposing factor to autoimmune syndromes. Clin. Exp. Rheumatol. 7(Suppl. 3):s95.
47. Lachmann, P. J., and M. J. Walport. 1987. Deficiency of the effector mechanisms of the immune response and autoimmunity. Ciba Found. Symp. 129:149.
48. Pascual, M., H. U. Lutz, G. Steiger, P. Stammler, and J. A. Schifferli. 1993. Release of vesicles enriched in complement receptor 1 from human erythrocytes. J. Immunol. 151:397.
49. Dervillez, X., S. Oudin, M. T. Libyh, T. Tabary, B. Reveil, F. Philbert, F. Bougy, M. Pluot, and J. H. Cohen. 1997. Catabolism of the human erythrocyte C3b/C4b receptor (CR1, CD35): vesiculation and/or proteolysis?. Immunopharmacology 38:129.
50. Pascual, M., C. Danielsson, G. Steiger, and J. A. Schifferli. 1994. Proteolytic cleavage of CR1 on human erythrocytes in vivo: evidence for enhanced cleavage in AIDS. Eur. J. Immunol. 24:702.
51. Barbosa, J. E., R. A. Harrison, P. J. Barker, and P. I. Lachmann. 1992. An anti-peptide antibody that recognizes a neo-antigen in the CR1 stump remaining on erythrocytes after proteolysis. Clin. Exp. Immunol. 87:144.
52. Makrides, S. C., P. A. Nygren, B. Andrews, P. J. Ford, K. S. Evans, E. G. Hayman, H. Adari, M. Uhlen, and C. A. Toth. 1996. Extended in vivo half-life of human soluble complement receptor type 1 fused to a serum albumin-binding receptor. J. Pharmacol. Exp. Ther. 277:534.
53. Hardig, Y., P. Garcia de Frutos, and B. Dahlback. 1995. Expression and characterization of a recombinant C4b-binding protein lacking the β-chain. Biochem. J. 308:795.
54. Cartron, J. P., and P. Agre. 1995. Rh Blood groups and Rh-deficiency syndrome. In Molecular Basis of Human Blood Group Antigens, Vol. 6. J. P. Cartron and P. Rouger, eds. Plenum Press, New York, p. 37.