Rheumatoid arthritis and pigmented villonodular synovitis: Comparative analysis of cell polyploidy, cell cycle phases and expression of macrophage and fibroblast markers in proliferating synovial cells

Histopathology

Volumn 46, Issue 5, 2005, Pages 490-497

  Berger, Irina ^a   Weckauf, H ^a   Helmchen, B ^a   Ehemann, V ^a   Penzel, R ^a   Fink, B ^b   Bernd, L ^a   Autschbach, F ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Coexpression; Polyploidy; Rheumatoid arthritis; Villonodular synovitis

Indexed keywords

ANTIGEN; CD163 ANTIGEN; CD68 ANTIGEN; CELL MARKER; DECAY ACCELERATING FACTOR; DNA; KI 67 ANTIGEN; PROTEIN H4PH; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANEUPLOIDY; ARTICLE; CELL CYCLE; CELL LABELING; CELL PROLIFERATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONFOCAL LASER MICROSCOPY; FEMALE; FIBROBLAST; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MACROPHAGE; MALE; PIGMENTED VILLONODULAR SYNOVITIS; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM;

ANTIGENS, CD; ANTIGENS, CD55; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CELL PROLIFERATION; DNA; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MACROPHAGES; PROCOLLAGEN-PROLINE DIOXYGENASE; RECEPTORS, CELL SURFACE; SYNOVIAL MEMBRANE; SYNOVITIS, PIGMENTED VILLONODULAR;

EID: 18244396941     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2005.01959.x     Document Type: Article

References (20)

1. Faßbender HG. Pathology and pathobiology of rheumatic diseases. Berlin, Heidelberg: Springer, 2002.
2. Nanki T, Nagasaka K, Hayashida K, Saita J, Miyasaka N. Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J. Immunol. 2001: 167; 5381-5385.
3. Ritchlin C, Haas-Smith SA. Expression of interleukin 10 mRNA and protein by synovial fibroblastoid cells. J. Rheumatol. 2001: 28; 689-705.
4. Sarkissian M, Lafyatis R, Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts. J. Immunol. 2000: 162; 1772-1779.
5. Seemayer CA, Distler O, Kuchen S et al. Die Rheumatoide Arthritis: Neuentwicklungen in der Pathogenese unter besonderer Berücksichtigung der synovialen Fibroblasten. Z. Rheumatol. 2001: 60; 309-318.
6. Aigner T, Oehlen S, Niedobitek HG, Faßbender HG, Kirchner T. Eisenablagerungen, Zellpopulationen und proliferative Aktivität in der pigmentierten villonodulären Synovitis des Kniegelenkes. Verh. Dtsch. Ges. Pathol. 1998: 82; 2327-2331,
7. Flandry F, Hughston JC, McCann SB, Kurtz DM. Diagnostic features of diffuse pigmented villonodular synovitis of the knee. Clin. Orthop. 1994: 298; 212-220.
8. Kobayashi H, Kotoura Y, Hosono M et al. Case report: uptake of pentavalent technetium-99m dimercaptosuccinic acid by pigmented villonodular synovitis: comparison with computed tomography, magnetic resonance imaging and gallium-67 scintigraphy. B. J. Radiol. 1994: 67; 1030-1032.
9. O'Keefe RJ, Rosier RN, Teot LA, Stewart JM, Hicks DG. Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. Iowa Orthop. 1998: 18; 26-34,
10. Smith MD, Barg E, Weedon H et al. Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints. Ann. Rheum. Dis. 2003: 62; 303-307.
11. Muller-Ladner U, Gay S. The SCID mouse - a novel experimental model for gene therapy in human rheumatoid arthritis. Drugs Today (Barc.) 1999: 35; 379-388.
12. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA, Method for analysis of cellular DNA-content of paraffin-embedded pathological material using flow cytometry. J. Histochem. Cytochem. 1983: 31; 1333-1335.
13. Ehemann V, Eifert A, Lange A, Otto HF. Flow cytometric DNA-analysis and chromosomal aberrations in malignant glioblastomas. Cancer Lett. 1999: 138; 101-106.
14. Sergi C, Ehemann V, Beedgen B, Linderkamp O, Otto HF. Huge fetal sacrococcygeal teratoma with a completely formed eye and intratumoral DNA heterogenity. Pediatr. Dev. Pathol. 1999: 2; 50-57.
15. Otto FJ. High-resolution analysis of nuclear DNA employing the fluorochrome DAPI. In Darzynkiewicz Z, Robinson JP, Crissman HA eds. Methods in cell biology. Vol. 41, Flow cytometry. San Diego: Acacemic Press, 1994; 211-217.
16. Hamann J, Wishaupt JO, van Lier RA, Smeets TJ, Breedveld FC, Tak PP. Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. Arthritis Rheum. 1999: 42; 650-658.
17. Konttinen YT, Nykanen P, Nordstrom D et al. DNA synthesis in prolyl 4-hydroxylase positive fibroblasts in situ in synovial tissue. An autoradiography-immunoperoxidase double labeling study. J. Rheumatol. 1989: 16: 339-345.
18. Kallioniemi OP, Visakorpi T, Holli K, Isola JJ, Rabinovitch PS. Automated peak detection and cell cycle analysis of flow cytometric DNA histograms. Cytometrie 1994: 16; 250-255.
19. Rabinovich PS. Practical considerations for DNA content and cell cycle analysis. In Bauer KD, Duque RE, Shankey TV eds. Clinical Flow Cytometry: Principles and Clinical Applications. Baltimore: Williams & Wilkins. 1993: 117.
20. Perka C, Labs K, Zippel H, Buttgereit F. Localised pigmented villonodular synovitis of the knee joint: neoplasm or reactive granuloma? A review of 18 cases. Rheumatology (Oxford) 2000: 39; 172-178.