Synthesis and biological evaluation of novel thio-substituted chromanes as high-affinity partial agonists for the estrogen receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 1, 2002, Pages 17-19

  Christiansen, Lise B ^a   Wenckens, Martin ^a   Bury, Paul S ^a   Gissel, Birgitte ^a   Hansen, Birgit S ^a   Thorpe, Susan M ^a   Jacobsen, Poul ^a   Kanstrup, Anders ^a   Jorgensen, Anker S ^a   Narum, Lars ^a   Wassermann, Karsten ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXY 3 PHENYL 4 [4 (2 PIPERIDINOETHANETHIO)PHENYL]CHROMANE; 7 HYDROXY 3 PHENYL 4 [4 (2 PIPERIDINOETHOXY)PHENYL]CHROMANE; 7 HYDROXY 3 PHENYL 4 [4 (2 PYRROLIDINOETHANETHIO)PHENYL]CHROMANE; 7 HYDROXY 3 PHENYL 4 [4 (2 PYRROLIDINOETHOXY)PHENYL]CHROMANE; CENTCHROMAN; CHROMAN DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR; IDOXIFENE; MOXESTROL; RALOXIFENE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IC 50;

ANIMALS; BINDING, COMPETITIVE; CHROMANS; DRUG EVALUATION, PRECLINICAL; ENDOMETRIUM; ESTRADIOL; FEMALE; RABBITS; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR COMPOUNDS;

EID: 18244396627     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00679-5     Document Type: Article

References (27)