Evaluation of the gene expression changes induced by 17-α-ethynyl estradiol in the immature uterus/ovaries of the rat using high density oligonucleotide arrays

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 74, Issue 2, 2005, Pages 164-184

  Naciff, Jorge M ^a   Torontali, Suzanne M ^a   Overmann, Gary I ^a   Carr, Gregory J ^a   Tiesman, Jay P ^a   Daston, George P ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

17 ethynyl estradiol; Gene expression profiling; Immature rat uterotrophic assay; Microarrays

Indexed keywords

ETHINYLESTRADIOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; ESTROGEN ACTIVITY; EVALUATION; EXPRESSED SEQUENCE TAG; FEMALE; GENE EXPRESSION PROFILING; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; PARAMETER; PERINATAL PERIOD; PREDICTION; PRIORITY JOURNAL; RAT; RAT STRAIN; UNINDEXED SEQUENCE; UTERUS;

ANIMALS; BIOLOGICAL ASSAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; INJECTIONS, SUBCUTANEOUS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARY; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UTERUS;

ANIMALIA;

EID: 18244393721     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.20032     Document Type: Article

References (32)

1. Adachi T, Ono Y, Koh KB, Takashima K, Tainaka H, Matsuno Y, Nakagawa S, Todaka E, Sakurai K, Fukata H, Iguchi T, Komiyama M, Mori C. 2004. Long-term alteration of gene expression without morphological change in testis after neonatal exposure to genistein in mice: toxicogenomic analysis using cDNA microarray. Food Chem Toxicol 42:445-452.
2. Akingbemi BT, Sottas CM, Koulova AI, Klinefelter GR, Hardy MP. 2004. Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology 145:592-603.
3. Britt KL, Findlay JK. 2002. Estrogen actions in the ovary revisited. J Endocrinol 175:269-276.
4. Couse JF, Lindzey J, Grandien K, Gustafsson JA, Korach KS. 1997. Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology 138:4613-4621.
5. Couse JF, Korach KS. 1999. Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20:358-417.
6. Couse JF, Korach KS. 2001. Contrasting phenotypes in reproductive tissues of female estrogen receptor null mice. Ann NY Acad Sci 948:1-8.
7. Couse JE, Mahato D, Eddy EM, Korach KS. 2001. Molecular mechanism of estrogen action in the male: insights from the estrogen receptor null mice. Reprod Fertil Dev 13:211-219.
8. Curtis HS, Couse JF, Korach KS. 2000. Estrogen receptor transcription and transactivation: estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action. Breast Cancer Res 2:345-352.
9. Fertuck KC, Eckel JE, Gennings C, Zacharewski TR. 2003. Identification of temporal patterns of gene expression in the uteri of immature, ovariectomized mice following exposure to ethynylestradiol. Physiol Genomics 15:127-141.
10. Frank GR. 2003. Role of estrogen and androgen in pubertal skeletal physiology. Med Pediatr Oncol 41:217-221.
11. Gill A, Jamnongjit M, Flammes SR. 2004. Androgens promote maturation and signaling in mouse oocytes independent of transcription: a release of inhibition model for mammalian oocyte meiosis. Mol Endocrinol 18:97-104.
12. Gustafsson JA. 2003. What pharmacologists can learn from recent advances in estrogen signalling. Trends Pharmacol Sci 24:479-485.
13. Hall JM, Couse JF, Korach KS. 2001. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276: 36869-32872.
14. Hess RA. 2003. Estrogen in the adult male reproductive tract: a review. Reprod Biol Endocrinol 1:52.
15. Huang E, West M, Nevins JR. 2003. Gene expression profiling for prediction of clinical characteristics of breast cancer. Recent Prog Horm Res 58:55-73.
16. Jo M, Gieske MC, Payne CE, Wheeler-Price SE, Gieske JB, Ignatius IV, Curry TE Jr, Ko C. 2004. Development and application of a rat ovarian gene expression database. Endocrinology 145:5384-5396.
17. Kanno J, Onyon L, Peddada S, Ashby J, Jacob E, Owens W. 2003. The OECD program to validate the rat uterotrophic bioassay. Phase 2: dose-response studies. Environ Health Perspect 111:1530-1549.
18. Klinge CM. 2001. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res 29:2905-2919.
19. Landschulz KT, Pathak RK, Rigotti A, Krieger M, Hobbs HH. 1996. Regulation of scavenger receptor, class B, type 1, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat. J Clin Invest 98:984-995.
20. Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H, Brown EL. 1996. Expression monitoring by hybridization to high-density oligonucletide arrays. Nat Biotechnol 14:1675-1680.
21. Naciff JM, Jump ML, Torontali SM, Carr GJ, Tiesman JP, Overmann GJ, Daston GP. 2002. Gene expression profile induced by 17α-ethynyl estradiol, bisphenol a, and genistein in the developing female reproductive system of the rat. Toxicol Sci 68:184-199.
22. Naciff JM, Overmann GJ, Torontali SM, Carr GJ, Tiesman JP, Richardson BD, Daston GP. 2003. Gene expression profile induced by 17 alpha-ethynyl estradiol in the prepubertal female reproductive system of the rat. Toxicol Sci 72:314-330.
23. Naciff JM, Overmann GJ, Torontali SM, Carr GJ, Tiesman JP, Daston GP. 2004. Impact of the phytoestrogen content of laboratory animal feed on the gene expression profile of the reproductive system in the immature female rat. Environ Health Perspect 112:1519-1526.
24. Newbold RR, Jefferson WN, Padilla-Banks E, Haseman J. 2004. Developmental exposure to diethylstilbestrol (DES) alters uterine response to estrogens in prepubescent mice: low versus high dose effects. Reprod Toxicol 18:399-406.
25. Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M, Gustafsson JA. 2001. Mechanisms of estrogen action. Physiol Rev 81:1535-1565.
26. Noda S, Sawaki M, Shiraishi K, Yamasaki K, Yamaguchi R. 2002. Age-related changes of genital systems in the female Crj:CD (SD) IGS rats during sexual maturation. J Vet Med Sci 64:315-319.
27. Riggs BL, Hartmann LC. 2003. Selective estrogen-receptor modulators-mechanisms of action and application to clinical practice. N Engl J Med 348:618-629.
28. Shang Y, Brown M. 2002. Molecular determinants for the tissue specificity of SERMs. Science 295:2465-2468.
29. Thigpen JE, Setchell KD, Ahlmark KB, Locklear J, Spahr T, Caviness GF, Goelz MF, Haseman JK, Newbold RR, Forsythe DB. 1999. Phytoestrogen content of purified, open- and closed-formula laboratory animal diets. Lab Anim Sci 49:530-536.
30. Toorop AI, Meijs-Roelofs HM, Kramer P, de Greef WJ. 1984. Ovarian steroid concentrations in rats approaching first ovulation. J Endocrinol 100:281-286.
31. Toran-Allerand DC. 2004. Minireview: a plethora of estrogen receptors in the brain: where will it end? Endocrinology 145:1069-1074.
32. Williams CL, Stancel GM. 1996. Estrogens and progestins. In: Hardman G, Limbird L, editors. Goodman and Gilman's pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill. p 1411-1440.