Relationship between toxicity and cadmium accumulation in rats given low amounts of cadmium chloride or cadmium-polluted rice for 22 months

Journal of Toxicological Sciences

Volumn 26, Issue 5, 2001, Pages 337-358

  Shibutani, Makoto ^a   Mitsumori, Kunitoshi ^a   Satoh, Shin Ichi ^b   Hiratsuka, Hideaki ^c   Satoh, Masahiko ^d   Sumiyoshi, Masami ^e   Motohiro, Nishijima ^f   Katsuki, Yasutaka ^f   Suzuki, Jin ^f   Nakagawa, Jun Ichi ^f   Akagi, Takumi ^g   Imazawa, Takayoshi ^a   Ando, Masanori ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b N   (Japan)

^c MITSUBISHI CHEMICAL CORPORATION   (Japan)

^d NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^e JAPAN FOOD RESEARCH LABORATORIES   (Japan)

^f TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

^g RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Cadmium; Long term exposure; Low dose feeding study; Lysosomes; Metallothionein; Renal toxicity

Indexed keywords

CADMIUM; CADMIUM CHLORIDE; METALLOTHIONEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ACCUMULATION; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; ERYTHROCYTE; EXOCYTOSIS; FEMALE; FOOD CONTAMINATION; HISTOPATHOLOGY; KIDNEY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; LIVER TOXICITY; LONG TERM EXPOSURE; LYSOSOME; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; NEPHROTOXICITY; NONHUMAN; RAT; RICE;

ANIMALIA;

EID: 18244387490     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.26.337     Document Type: Article

References (45)

1. Induction of oxidative stress by chronic administration of sodium dichromate [chromium VI] and cadmium chloride [cadmium II] to rats
2. Properties of sufficiency and statistical tests
3. Time course of chronic oral cadmium nephrotoxi city in Wistar rats: Excretion of urinary enzymes
4. Correlation of cadmium-induced nephropathy and the metabolism of endogenous copper and zinc in rats
5. 109 studies in the mouse
6. Discrepancy between the nephrotoxic potencies of cadmium-metallothionein and cadmium chloride and the renal concentration of cadmium in the proximal convoluted tubules
7. Acute exposure to cadmium causes severe liver injury in rats
8. New tables for multiple comparisons with a control
9. Nutritional factors that may influence bioavailability of cadmium
10. Non-metallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat
11. Comparison of renal toxicity after long-term oral administration of cadmium chloride and cadmium-metallothionein in rats
12. Pathological study on beagles after long-term oral administration of cadmium
13. Apoptosis of human kidney 293 cells is promoted by polymerized cadmium-metallothionein
14. Tissue distribution of cadmium in rats given minimum amounts of cadmium-polluted rice or cadmium chloride for 8 months
15. Effects of cadmium on superoxide dismutase and lipid peroxidation in liver and kidney of growing rats: In vivo and in vitro studies
16. An ultrastructural study on cadmium-induced damage of the renal proximal tubules of rats
17. Induction of hepatic metallothionein I in tumourbearing mice
18. Use of ranks in one-criterion variance analysis
19. 2 and CdMT exposure with acute CdMT injection in rats
20. On a test of whether one of two random variables is stochastically larger than the other
21. Relationship between the development of hepatorenal toxicity and cadmium accumulation in rats given minimum to large amounts of cadmium chloride in the long term: Preliminary study
22. Localization of metallothionein in female reproductive organs of rat and guinea pig
23. A doseresponse analysis of cadmium in the general environment with special reference to total cadmium intake limit
24. Critical concentration of unbound cadmium in the rabbit renal cortex
25. Health effects of six years of dietary cadmium (cadmium-contaminated rice) in monkeys
26. Metabolic model for cadmium in man
27. Kinetics and metabolism
28. Cadmium content in rice and its daily intake in various countries
29. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants
30. Protection against chronic cadmium toxicity by caloric restriction
31. Assessment of renal toxicity by analysis of regeneration of tubular epithelium in rats given low dose cadmium chloride or cadmium-polluted rice for 22-months
32. Cadmium-metallothionein nephrotoxicity: Relationship between ultrastructural/biochemical alterations and intercellular cadmium binding
33. Characteristic induction of hepatic metallothionein in mice by tumor transplantation
34. Cell death and regeneration of renal proximal tubular cells in rats with subchronic cadmium intoxication
35. 2-exposed rat kidney: Relationship with apoptosis and regeneration
36. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
37. Cadmium
38. Cadmium
39. Cadmium
40. Cadmium
41. A simple histological method for identification of osteoid matrix in decalcified bone