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Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis
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Ryckman C, McColl SR, Vandal K, et al. Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis. Arthritis Rheum 2003; 48:2310-2320.
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Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils
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Ryckman C, Gilbert C, De Medicis R, et al. Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils. J Leukoc Biol 2004; 76:433-440. This paper further examines mechanisms of S100A8/A9 release in gout, and demonstrates that MSU crystals directly induce the release of these proteins from neutrophils.
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Signaling events involved in macrophage chemokine expression in response to monosodium urate crystals
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Jaramillo M, Godbout M, Naccache PH, Olivier M. Signaling events involved in macrophage chemokine expression in response to monosodium urate crystals. J Biol Chem 2004; 279:52797-52805. Epub 2004 Oct 07.
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Jaramillo, M.1
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Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells
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Liu R, O'Connell M, Johnson K, et al. Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis Rheum 2000; 43:1145-1155.
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Plasma protein binding by monosodium urate crystals. Analysis by two-dimensional gel electrophoresis
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Central Role of Complement Membrane Attack Complex in Monosodium Urate Crystal-Induced Neutrophilic Rabbit Knee Synovitis
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Tramontini N, Huber C, Liu-Bryan R, et al. Central Role of Complement Membrane Attack Complex in Monosodium Urate Crystal-Induced Neutrophilic Rabbit Knee Synovitis. Arthritis Rheum 2004; 50:2633-2639. This paper identifies the complement membrane attack complex as a novel mechanism for neutrophil recruitment in acute MSU crystal-induced arthritis.
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Tramontini, N.1
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Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis
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Getting SJ, Di Filippo C, Lam CW, et al. Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. J Pharmacol Exp Ther 2004; 310:90-97. This group examined the effect of endothelin-1 receptor blockade in the murine MSU-crystal-induced peritonitis model, and demonstrated for the first time that blockade of the ETA and ETB receptors attenuates the inflammatory response to MSU crystals.
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Getting, S.J.1
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The involvement of phosphatidylinositol 3-kinase in crystal induced human neutrophil activation
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Jackson JK, Lauener R, Duronio V, Burt HM. The involvement of phosphatidylinositol 3-kinase in crystal induced human neutrophil activation. J Rheumatol 1997; 24:341-348.
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Calcium pyrophosphate dihydrate crystals activate MAP kinase in human neutrophils: Inhibition of MAP kinase, oxidase activation and degranulation responses of neutrophils by taxol
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Jackson JK, Tudan C, Sahl B, et al. Calcium pyrophosphate dihydrate crystals activate MAP kinase in human neutrophils: inhibition of MAP kinase, oxidase activation and degranulation responses of neutrophils by taxol. Immunology 1997; 90:502-510.
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Calcium pyrophosphate dihydrate crystal associated induction of neutrophil activation and repression of TNF-alpha-induced apoptosis is mediated by the p38 MAP kinase
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Tudan C, Jackson JK, Higo TT, et al. Calcium pyrophosphate dihydrate crystal associated induction of neutrophil activation and repression of TNF-alpha-induced apoptosis is mediated by the p38 MAP kinase. Cell Signal 2004; 16:211-221. This paper extends previous work examining neutrophil signalling pathways, and demonstrates that the p38 MAPK pathway plays a role in neutrophil activation and survival following exposure to CPPD crystals.
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Cell Signal
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Tudan, C.1
Jackson, J.K.2
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Substance P immunoreactive nerve fibres in the domestic chick ankle joint before and after acute urate arthritis
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Lunam CA, Gentle MJ. Substance P immunoreactive nerve fibres in the domestic chick ankle joint before and after acute urate arthritis. Neurosci Lett 2004; 354:87-90. This report identifies substance P as a potential modulator of inflammation in the acute gout attack, showing that substance P is rapidly depleted from nerve fibres following intra-articular injection of MSU crystals.
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Lunam, C.A.1
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Ventura-Martinez R, Deciga-Campos M, Diaz-Reval MI, et al. Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat. Eur J Pharmacol 2004; 503:43-48. This paper demonstrates that NO may mediate indomethacin-induced antinociception in rats with experimental urate monoarthritis.
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Monosodium urate crystals synergize with IFN-gamma to generate macrophage nitric oxide: Involvement of extracellular signal-regulated kinase 1/2 and NF-kappa B
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Jaramillo M, Naccache PH, Olivier M. Monosodium urate crystals synergize with IFN-gamma to generate macrophage nitric oxide: involvement of extracellular signal-regulated kinase 1/2 and NF-kappa B. J Immunol 2004; 172:5734-5742. This paper examines mechanisms of NO release by macrophages in response to MSU crystals. The key findings are that MSU crystals alone do not induce the production of NO, but synergize with interferon-γ to promote NO release. Activation of the ERK1/2 and NF-κB pathways is shown to mediate this effect.
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Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes
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Liu R, Liote F, Rose DM, et al. Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes. Arthritis Rheum 2004; 50:247-258. This group reports that MSU crystals induce chondrocyte release of MMP-3 and NO. They also identify a key role for the Pyk-2/Src/paxillin complex in p38 MAPK activation within chondrocytes in response to MSU crystals.
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Arthritis Rheum
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Molecular mechanism of the induction of metalloproteinases 1 and 3 in human fibroblasts by basic calcium phosphate crystals. Role of calcium-dependent protein kinase C alpha
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Reuben PM, Brogley MA, Sun Y, Cheung HS. Molecular mechanism of the induction of metalloproteinases 1 and 3 in human fibroblasts by basic calcium phosphate crystals. Role of calcium-dependent protein kinase C alpha. J Biol Chem 2002; 277:15190-15198.
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Reuben PM, Sun Y, Cheung HS. Basic calcium phosphate crystals activate p44/42 MAPK signal transduction pathway via protein kinase Cmicro in human fibroblasts. J Biol Chem 2004; 279:35719-35725. This paper identifies PKCμ as a novel signalling mediator in BCP crystal-induced activation of fibroblasts.
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Morgan MP, Whelan LC, Sallis JD, et al. Basic calcium phosphate crystal-induced prostaglandin E2 production in human fibroblasts: role of cyclooxygenase 1, cyclooxygenase 2, and interleukin-1beta. Arthritis Rheum 2004; 50:1642-1649. The authors demonstrate that BCP crystals induce early expression of COX-2 within fibroblasts in a manner that is partially dependent on PKC and PI3K. They also show that expression of mRNA for IL-1β is increased in response to BCP crystals. Both IL-1β and COX-2 mRNA expression is suppressed by phosphocitrate.
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Arthritis Rheum
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Yagnik DR, Evans BJ, Florey O, et al. Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum 2004; 50:2273-2280. Using both in-vitro and in-vivo models, this report further supports the role of TGFβ1 as a potential anti-inflammatory mediator released by mature human macrophages in response to MSU crystals.
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Arthritis Rheum
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Yagnik, D.R.1
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