Regulatory cytokine expression and interstitial fluid formation in the normal and inflamed rat testis are under Leydig cell control

Journal of Andrology

Volumn 26, Issue 3, 2005, Pages 379-386

  Hedger, Mark ^a   Klug, Jörg ^b   Fröhlich, Suada ^b   Müller, Ruth ^b   Meinhardt, Andreas ^b  

^a MONASH UNIVERSITY   (Australia)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Ethane dimethane sulfonate; Interferon ; Macrophage migration inhibitory factor; Testosterone; Transforming growth factor

Indexed keywords

ETHYLENE GLYCOL DIMESYLATE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; MACROPHAGE MIGRATION INHIBITION FACTOR; TESTOSTERONE; TRANSFORMING GROWTH FACTOR BETA1;

ANDROGEN RELEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SECRETION; CONTROLLED STUDY; CYTOKINE PRODUCTION; INFLAMMATION; INTERSTITIAL FLUID; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TESTIS; TESTOSTERONE SYNTHESIS;

ANIMALS; CYTOKINES; EXTRACELLULAR FLUID; GENE EXPRESSION; INTERFERON TYPE II; LEYDIG CELLS; LIPOPOLYSACCHARIDES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; MESYLATES; ORCHITIS; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 18244375542     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.04149     Document Type: Article

References (48)

1. Avallet O, Vigier M, Leduque P, Dubois PM, Saez JM. Expression and regulation of transforming growth factor-beta 1 messenger ribonucleic acid and protein in cultured porcine Leydig and Sertoli cells. Endocrinology. 1994;134:2079-2087.
2. Bergh A, Damber JE, Widmark A. A physiological increase in LH may influence vascular permeability in the rat testis. J Reprod Fertil. 1990;89:23-31.
3. Bosmann HB, Hales KH, Li X, Liu Z, Stocco DM, Hales DB. Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic acute regulatory (StAR) protein in Leydig cells. Endocrinology. 1996;137:4522-4525.
4. Caussanel V, Tabone E, Hendrick JC, Dacheux F, Benahmed M. Cellular distribution of transforming growth factor betas 1, 2, and 3 and their types I and II receptors during postnatal development and spermatogenesis in the boar testis. Biol Reprod. 1997;56:357-367.
5. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques. 1993;15:532-534, 535-537.
6. Collin O, Bergh A. Leydig cells secrete factors which increase vascular permeability and endothelial cell proliferation. Int J Androl. 1996;19:221-228.
7. Collin O, Bergh A, Damber JE, Widmark A. Control of testicular vasomotion by testosterone and tubular factors in rats. J Reprod Fertil. 1993;97:115-121.
8. Damber JE, Maddocks S, Widmark A, Bergh A. Testicular blood flow and vasomotion can be maintained by testosterone in Leydig cell-depleted rats. Int J Androl. 1992;15:385-393.
9. De SK, Chen HL, Pace JL, Hunt JS, Terranova PF, Enders GC. Expression of tumor necrosis factor-alpha in mouse spermatogenic cells. Endocrinology. 1993;133:389-396.
10. Dejucq N, Dugast I, Ruffault A, van der Meide PH, Jegou B. Interferon-alpha and -gamma expression in the rat testis. Endocrinology. 1995;136:4925-4931.
11. Gerdprasert O, O'Bryan MK, Muir JA, Caldwell AM, Schlatt S, de Kretser DM, Hedger MP. The response of testicular leukocytes to lipopolysaccharide- induced inflammation: further evidence for heterogeneity of the testicular macrophage population. Cell Tissue Res. 2002a;308:277-285.
12. Gerdprasert O, O'Bryan MK, Nikolic-Paterson DJ, Sebire K, de Kretser DM, Hedger MP. Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis. Mol Hum Reprod. 2002b;8:518-524.
13. Ghinea N, Mai TV, Groyer-Picard MT, Milgrom E. How protein hormones reach their target cells. Receptor-mediated transcytosis of hCG through endothelial cells. J Cell Biol. 1994;125:87-97.
14. Gow RM, O'Bryan MK, Canny BJ, Ooi GT, Hedger MP. Differential effects of dexamethasone treatment on lipopolysaccharide-induced testicular inflammation and reproductive hormone inhibition in adult rats. J Endocrinol. 2001;168:193-201.
15. Haagmans BL, Hoogerbrugge JW, Themmen AP, Teerds KJ. Rat testicular germ cells and Sertoli cells release different types of bioactive transforming growth factor beta in vitro. Reprod Biol Endocrinol. 2003;1:3.
16. Hales KH, Diemer T, Ginde S, Shankar BK, Roberts M, Bosmann HB, Hales DB. Diametric effects of bacterial endotoxin lipopolysaccharide on adrenal and Leydig cell steroidogenic acute regulatory protein. Endocrinology. 2000;141:4000-4012.
17. Head JR, Billingham RE. Immunologically privileged sites in transplantation immunology and oncology. Perspect Biol Med. 1985;29:115-131.
18. Hedger MP. Macrophages and the immune responsiveness of the testis. J Reprod Immunol. 2002;57:19-34.
19. Hedger MP, Hettiarachchi S. Measurement of immunoglobulin G levels in adult rat testicular interstitial fluid and serum. J Androl. 1994;15:583-590.
20. Hedger MP, Meinhardt A. Cytokines and the immune-testicular axis. J Reprod Immunol. 2003;58:1-26.
21. Hedger MP, Wang J, Lan HY, Atkins RC, Wreford NG. Immunoregulatory activity in adult rat testicular interstitial fluid: relationship with intratesticular CD8+ lymphocytes following treatment with ethane dimethane sulfonate and testosterone implants. Biol Reprod. 1998;58:935-942.
22. Huang WJ, Yeh JY, Kan SF, Chang LS, Wang PS. Role of testicular interstitial macrophages in regulating testosterone release in hyperprolactinemia. J Cell Biochem. 2003;88:766-773.
23. Kern S, Robertson SA, Mau VJ, Maddocks S. Cytokine secretion by macrophages in the rat testis. Biol Reprod. 1995;53:1407-1416.
24. Kerr JB, Donachie K, Rommerts FF. Selective destruction and regeneration of rat Leydig cells in vivo. A new method for the study of seminiferous tubular-interstitial tissue interaction. Cell Tissue Res. 1985;242:145-156.
25. Konrad L, Albrecht M, Renneberg H, Aumuller G. Transforming growth factor-beta2 mediates mesenchymal-epithelial interactions of testicular somatic cells. Endocrinology. 2000;141:3679-3686.
26. Maddocks S, Sharpe RM. Interstitial fluid volume in the rat testis: androgen-dependent regulation by the seminiferous tubules? J Endocrinol. 1989;120:215-222.
27. Meinhardt A, Bacher M, McFarlane JR, Metz CN, Seitz J, Hedger MP, de Kretser DM, Bucala R. Macrophage migration inhibitory factor production by Leydig cells: evidence for a role in the regulation of testicular function. Endocrinology. 1996;137:5090-5095.
28. Meinhardt A, Bacher M, Metz C, Bucala R, Wreford N, Lan H, Atkins R, Hedger M. Local regulation of macrophage subsets in the adult rat testis: examination of the roles of the seminiferous tubules, testosterone, and macrophage-migration inhibitory factor. Biol Reprod. 1998;59:371-378.
29. Meinhardt A, Bacher M, O'Bryan MK, et al. A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment. J Cell Sci. 1999;112(pt 9):1337-1344.
30. Mullaney BP, Skinner MK. Transforming growth factor-beta (beta 1, beta 2, and beta 3) gene expression and action during pubertal development of the seminiferous tubule: potential role at the onset of spermatogenesis. Mol Endocrinol. 1993;7:67-76.
31. O'Bryan MK, Schlatt S, Gerdprasert O, Phillips DJ, de Kretser DM, Hedger MP. Inducible nitric oxide synthase in the rat testis: evidence for potential roles in both normal function and inflammation-mediated infertility. Biol Reprod. 2000a;63:1285-1293.
32. O'Bryan MK, Schlatt S, Phillips DJ, de Kretser DM, Hedger MP. Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo. Endocrinology. 2000b;141:238-246.
33. Pentikainen V, Erkkila K, Suomalainen L, Otala M, Pentikainen MO, Parvinen M, Dunkel L. TNF alpha down-regulates the Fas ligand and inhibits germ cell apoptosis in the human testis. J Clin Endocrinol Metab. 2001;86:4480-4488.
34. Setchell BP. Local control of testicular fluids. Reprod Fertil Dev. 1990;2:291-309.
35. Setchell BP, Maddocks S, Brooks D. Anatomy, vasculature, innervation, and fluids of the male reproductive tract. In: Knobil E, Neill J, eds. The Physiology of Reproduction. New York: Raven Press; 1994:1063-1173.
36. Setchell BP, Sharpe RM. Effect of injected human chorionic gonadotrophin on capillary permeability, extracellular fluid volume and the flow of lymph and blood in the testes of rats. J Endocrinol. 1981;91:245-254.
37. Sewer MB, Morgan ET. Down-regulation of the expression of three major rat liver cytochrome P450S by endotoxin in vivo occurs independently of nitric oxide production. J Pharmacol Exp Ther. 1998;287:352-358.
38. Sharpe RM, Bartlett JM, Allenby G. Evidence for the control of testicular interstitial fluid volume in the rat by specific germ cell types. J Endocrinol. 1991;128:359-367.
39. Sharpe RM, Cooper I. Testicular interstitial fluid as a monitor for changes in the intratesticular environment in the rat. J Reprod Fertil. 1983;69:125-135.
40. Sharpe RM, Maddocks S, Kerr JB. Cell-cell interactions in the control of spermatogenesis as studied using Leydig cell destruction and testosterone replacement. Am J Anat. 1990;188:3-20.
41. Soder O, Sultana T, Jonsson C, Wahlgren A, Petersen C, Holst M. The interleukin-1 system in the testis. Andrologia. 2000;32:52-55.
42. Stephan JP, Syed V, Jegou B. Regulation of Sertoli cell IL-1 and IL-6 production in vitro. Mol Cell Endocrinol. 1997;134:109-118.
43. Sun YT, Robertson DM, Gonzales G, Risbridger GP, de Kretser DM. Effect of testosterone on serum immunoactive inhibin concentrations in intact and hypophysectomized male rats. J Reprod Fertil. 1989;87:795-801.
44. Syed V, Gerard N, Kaipia A, Bardin CW, Parvinen M, Jegou B. Identification, ontogeny, and regulation of an interleukin-6-like factor in the rat seminiferous tubule. Endocrinology. 1993;132:293-299.
45. Teerds KJ, Dorrington JH. Localization of transforming growth factor beta 1 and beta 2 during testicular development in the rat. Biol Reprod. 1993;48:40-45.
46. Veijola M, Rajaniemi H. Luteinising hormones activate a factor(s) in testicular interstitial fluid which increases testicular vascular permeability. Mol Cell Endocrinol. 1986;45:113-118.
47. Wang J, Wreford NG, Lan HY, Atkins R, Hedger MP. Leukocyte populations of the adult rat testis following removal of the Leydig cells by treatment with ethane dimethane sulfonate and subcutaneous testosterone implants. Biol Reprod. 1994;51:551-561.
48. Xiong Y, Hales DB. The role of tumor necrosis factor-alpha in the regulation of mouse Leydig cell steroidogenesis. Endocrinology. 1993;132:2438-2444.