Effects of zinc deficiency and pinealectomy on cellular immunity in rats infected with Toxoplasma gondii

Biological Trace Element Research

Volumn 104, Issue 1, 2005, Pages 47-56

  Baltaci, Abdulkerim Kasim ^a   Mogulkoc, Rasim ^a   Bediz, Cem Seref ^b   Pekel, Aysel ^c  

^a SELCUK UNIVERSITY   (Turkey)

^b DOKUZ EYLUL UNIVERSITY   (Turkey)

^c GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Cellular immunity; Pinealectomy; T. gondii infection; Toxoplasmosis; Zinc deficiency

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; MELATONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BLOOD SMEAR; CELLULAR IMMUNITY; CONTROLLED STUDY; HORMONE DEFICIENCY; LYMPHOCYTE COUNT; NONHUMAN; PINEALECTOMY; RAT; T LYMPHOCYTE SUBPOPULATION; TOXOPLASMA GONDII; TOXOPLASMOSIS; ZINC DEFICIENCY;

EID: 18244375245     PISSN: 01634984     EISSN: None     Source Type: Journal    
DOI: 10.1385/bter:104:1:047     Document Type: Article

References (30)

1. E. Mocchegiani, R. Giacconi, M. Muzzioli, et al., Zinc, infections and immunosenescence, Mech. Ageing Dev. 121, 21-35 (2001).
2. G. Pawelec and R. Solana, Immunosenescence, Immunol. Today 18, 514-516 (1997).
3. A. H. Shankar and A. S. Prasad, Zinc and immune function: the biological basis of altered resistance to infection, Am. J. Clin. Nutr. 68, 447-463 (1998).
4. R. A. Wapnir, Zinc deficiency malnutrition and the gastrointestinal tract, J. Nutr. 130, 1388-1392 (2000).
5. J. W. Hadden, Thymic endocrinology, Ann. NY Acad. Sci. 1, 352-358 (1998).
6. A. S. Prasad, Zinc and immunity, Mol. Cell. Biochem. 188, 63-69 (1998).
7. A. S. Prasad, F. W. J. Beck, J. Kaplan, et al., Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD), Am. J. Hematol. 61, 194-202 (1999).
8. G. J. Maestroni, The immunoneuroendocrine role of melatonin, J. Pineal Res. 14, 1-10 (1993).
9. E. Mocchegiani, L. Santarelli, A. Tibaldi, et al., Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on survival, J. Neuroimmunol. 86, 111-112 (1998).
10. E. Mocchegiani, L. Perisin, L. Santarelli, et al., Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2, Int. J. Immunopharmacol. 21, 27-46 (1999).
11. S. K. Skwarlo-Sonta, Functional connections between the pineal gland and immune system, Acta. Neurobiol. Exp. 56, 341-357 (1996).
12. V. del Gobbo, V. Libri, N. Villani, et al., Pinealectomy inhibits interleukin-2 and natural killer activity in mice, Int. J. Immunopharmacol. 11, 567-573 (1989).
13. E. Mocchegiani, D. Bulian, L. Santarelli, et al., The immune-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in aging mice, J. Neuroimmunol. 53, 189-201 (1994).
14. E. Mocchegiani, D. Bulian, L. Santarelli, et al., The zinc pool is involved in the immune-reconstituting effect of melatonin in pinealectomized mice, J. Pharmacol. Exp. Ther. 277, 1200-1208 (1996).
15. G. J. Maestroni, Therapeutic potential of melatonin in immunodeficiency states, viral diseases, and cancer, Adv. Exp. Med. Biol. 467, 217-226 (1999).
16. A. Sher and R. L. Coffman, Regulation of immunity to parasites by T cells and T cell-derived cytokines, Annu. Rev. Immunol. 10, 385-409 (1992).
17. + T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite infected or antigen pulsed host cells, J. Immunol. 147, 2310-2316 (1991).
18. + cytotoxic T-lymphocytes lyse Toxoplasma gondii infected cells, J. Immunol. 147, 3955-3959 (1991).
19. J. Kuszak and M. A. Rodin, New technique of pinealectomy for adult rats. Experientia 33, 283-284 (1977).
20. B. L. Vallee and K. H. Falchuk, The biochemical basis of zinc physiology, Physiol. Rev. 73, 79-105 (1993).
21. P. J. Fraker, P. Jardieu, and J. Cook, Zinc deficiency and immune function, Arch. Dermatol 123, 1699-1701 (1987).
22. E. Beskonakli, S. Palaoglu, N. Renda, et al., The effect of pinealectomy on immune parameters in different age groups in rats: results of the weekly alteration of the zinc level and the effect of melatonin administration on wound healing, J. Clin. Neurosci. 7, 320-324 (2000).
23. C. M. Collazo, C. Miller, G. Yap, et al., Host resistance and immune deviation in pigeon cytochrome T-cell receptor transgenic mice infected with Toxoplasma gondii. Infect. Immun. 68, 2713-2719 (2000).
24. M. B. Purner, R. L. Berens, S. Tomavo, et al., Stimulation of human T lymphocytes obtained from Toxoplasma gondii serogenative persons by proteins derived from T. gondii, J. Infect. Dis. 177, 746-753 (1998).
25. A. S. Prasad, Effects of zinc deficiency on immune functions. J. Trace Elements Exp. Med. 13, 1-20 (2000).
26. M. E. Scott and K. G. Koski, Zinc deficiency impairs immune responses against parasitic nematode infections at intestinal and systemic sites, J. Nutr. 130, 1412-1420 (2000).
27. R. T. Gazzinelli, I. P. Oswald, S. L. James, et al., IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages, J. Immunol. 148, 1792-1796 (1992).
28. C. S. Subauste and M. Wessendarp, Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T cell production of IFN-γ, J. Immunol. 165, 1498-1505 (2000).
29. + immune T-cells againts toxoplasmosis in mice, J. Immunol. 144, 1954-1956 (1990).
30. T. Shirahata, N. Muroya, C. Ohta, et al., Correlation between increased susceptibility to primary Toxoplasma gondii infection and depressed production of gamma interferon in pregnant mice, Microbiol. Immunol. 36, 81-91 (1992).