Trace apparent diffusion coefficients of metabolites in human brain using diffusion weighted magnetic resonance spectroscopy

Magnetic Resonance in Medicine

Volumn 53, Issue 5, 2005, Pages 1025-1032

  Ellegood, Jacob ^a   Hanstock, Chris C ^a   Beaulieu, Christian ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Diffusion spectroscopy; Human brain; Metabolite; MRS; Trace

Indexed keywords

BRAIN; MAGNETIC RESONANCE; MAGNETIC RESONANCE SPECTROSCOPY; METABOLITES;

ACQUISITION MODES; APPARENT DIFFUSION COEFFICIENT; DIFFUSION GRADIENTS; DIFFUSION-WEIGHTED MAGNETIC RESONANCE; HUMAN BRAIN; N-ACETYL ASPARTATE; TISSUE MICROSTRUCTURES; TRACE;

SURFACE DIFFUSION;

CHOLINE; CREATINE; CREATINE PHOSPHATE; N ACETYLASPARTIC ACID;

ANISOTROPY; ARTICLE; BRAIN METABOLISM; DIFFUSION COEFFICIENT; FRONTAL CORTEX; GRAY MATTER; HUMAN; METABOLITE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL LOBE; WHITE MATTER;

EID: 18244367681     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.20427     Document Type: Article

References (21)

1. Tanner JE. Use of the stimulated echo in NMR diffusion studies. J Chem Phys 1970;52:2523-2526.
2. 31P application to phosphorus metabolites in muscle. Magn Reson Med 1990;13:467-477.
3. Sotak CH. Multiple quantum NMR spectroscopy methods for measuring the apparent self-diffusion coefficient of in vivo lactic acid. NMR Biomed 1991;4:70-72.
4. Nicolay K, van der Toorn A, Dijkhuizen RM. In vivo diffusion spectroscopy. An overview. NMR Biomed 1995;8:365-374.
5. Nicolay K, Braun KP, Graaf RA, Dijkhuizen RM, Kruiskamp MJ. Diffusion NMR spectroscopy. NMR Biomed 2001;14:94-111.
6. Merboldt KD, Horstermann D, Hanicke W, Bruhn H, Frahm J. Molecular self-diffusion of intracellular metabolites in rat brain in vivo investigated by localized proton NMR diffusion spectroscopy. Magn Reson Med 1993;29:125-129.
7. van der Toorn A, Verheul HB, Berkelbach van der Sprenkel JW, Tulleken CA, Nicolay K. Changes in metabolites and tissue water status after focal ischemia in cat brain assessed with localized proton MR spectroscopy. Magn Reson Med 1994;32:685-691.
8. Wick M, Nagatomo Y, Prielmeier F, Frahm J. Alteration of intracellular metabolite diffusion in rat brain in vivo during ischemia and reperfusion. Stroke 1995;26:1930-1933; p 1934.
9. 1H MRS. Magn Reson Med 1996;36:914-922.
10. Dijkhuizen RM, de Graaf RA, Tulleken KA, Nicolay K. Changes in the diffusion of water and intracellular metabolites after excitotoxic injury and global ischemia in neonatal rat brain. J Cereb Blood Flow Metab 1999;19:341-349.
11. Abe O, Okubo T, Hayashi N, Saito N, Iriguchi N, Shirouzu I, Kojima Y, Masumoto T, Ohtomo K, Sasaki Y. Temporal changes of the apparent diffusion coefficients of water and metabolites in rats with hemispheric infarction: experimental study of transhemispheric diaschisis in the contralateral hemisphere at 7 Tesla. J Cereb Blood Flow Metab 2000;20:726-735.
12. Dreher W, Busch E, Leibfritz D. Changes in apparent diffusion coefficients of metabolites in rat brain after middle cerebral artery occlusion measured by proton magnetic resonance spectroscopy. Magn Reson Med 2001;45:383-389.
13. Posse S, Cuenod CA, Le Bihan D. Human brain: proton diffusion MR spectroscopy. Radiology 1993;188:719-725.
14. Harada M, Uno M, Hong F, Hisaoka S, Nishitani H, Matsuda T. Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor. NMR Biomed 2002;15:69-74.
15. Basser PJ. Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed 1995;8:333-344.
16. de Graaf RA, Braun KP, Nicolay K. Single-shot diffusion trace (1)H NMR spectroscopy. Magn Reson Med 2001;45:741-748.
17. Mills R. Self-diffusion in normal and heavy water in the range 1-45 degrees. J Phys Chem 1973;77:685-688.
18. Jehenson P, Westphal M, Schuff N. Analytical method for the compensation of eddy-current effects induced by pulsed magnetic field gradients in NMR systems. J Magn Reson 1990;90:264-278.
19. 1H nuclear magnetic resonance spectroscopy in vivo. J Cereb Blood Flow Metab 2000;20:736-746.
20. Moonen CT, von Kienlin M, van Zijl PC, Cohen J, Gillen J, Daly P, Wolf G, Comparison of single-shot localization methods (STEAM and PRESS) for in vivo proton NMR spectroscopy. NMR Biomed 1989;2:201-208.
21. Mlynarik V, Gruber S, Moser E. Proton T (1) and T (2) relaxation times of human brain metabolites at 3 Tesla. NMR Biomed 2001;14:325-331.