Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS

Magnetic Resonance in Medicine

Volumn 36, Issue 6, 1996, Pages 914-922

  Van Der Toorn, Annette ^a,c   Dijkhuizen, Rick M ^a,b   Tulleken, Cees A F ^b   Nicolay, Klaas ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

ADC; brain metabolites; focal cerebral ischemia; rat

Indexed keywords

METABOLITES; RATING; RATS; SURFACE DIFFUSION;

APPARENT DIFFUSION COEFFICIENT; BRAIN METABOLITES; DIFFUSION CHARACTERISTICS; FOCAL CEREBRAL ISCHEMIAS; INTRACELLULAR COMPARTMENTS; N-ACETYL ASPARTATE; RAT BRAIN;

BRAIN;

CHOLINE; CREATINE; CREATINE PHOSPHATE; LACTIC ACID; N ACETYLASPARTIC ACID;

AMINO ACID ANALYSIS; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN WATER; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIFFUSION COEFFICIENT; MALE; NEUROLOGIC DISEASE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 0029913999     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910360614     Document Type: Article

References (54)

1. E. O. Stejskal, J. E. Tanner, Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J. Chem. Phys. 42, 288-292 (1965).
2. H. Benveniste, L. W. Hedlund, G. A. Johnson, Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke 23, 746-754 (1992).
3. D. Davis, J. Ulatowski, S. Eleff, M. Izuta, S. Mori, D. Shungu, Van P. C. M. Zijl, Rapid monitoring of changes in water diffusion coefficients during reversible ischemia in cat and rat brain. Magn. Reson. Med. 31, 454-460 (1994).
4. R. A. Knight, R. J. Ordidge, J. A. Helpern, M. Chopp, L. C. Rodolosi, D. Peck, Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging. Stroke 22, 802-808 (1991).
5. J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. E. Moseley, Diffusion/ perfusion MR imaging of acute cerebral ischemia. Magn. Reson. Med. 19, 311-315 (1991).
6. M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, P. R. Weinstein, Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn. Reson. Med. 14, 330-346 (1990).
7. A. Van der Toorn, H. B. Verheul, J. W. Berkelbach van der Sprenkel, C. A. F. Tulleken, K. Nicolay, Changes in metabolites and tissue water status after focal ischemia in cat brain assessed with localized proton MR spectroscopy. Magn. Reson. Med. 32, 685-691 (1994).
8. P. Van Gelderen, M. H. M. De Vleeschouwer, D. DesPres, J. Pekar, P. C. M. Van Zijl, C. T. W. Moonen, Water diffusion and acute stroke. Magn. Reson. Med. 31, 154-163 (1994).
9. K.-A. Hossmann, The pathophysiology of experimental brain edema. Neurosurg. Rev. 12, 263-280 (1989).
10. I. Klatzo, Neuropathological aspects of brain edema. J. Neuropathol. Exp. Neurol. 26, 1-14 (1967).
11. M. E. Moseley, J. Kucharczyk, J. Mintorovitch, Y. Cohen, J. Kurhanewicz, N. Derugin, H. Asgari, D. Norman, Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility enhanced MR imaging in cats. AJNR 11, 423-429 (1990).
12. D. G. Norris, T. Niendorf, M. Hoehn-Berlage, K. Kohno, E. J. Schneider, P. Hainz, M. Hropot, D. Leibfritz, Incidence of apparent restricted diffusion in three different models of cerebral infarction. Magn. Reson. Imaging 12, 1175-1182 (1994).
13. K.-D. Merboldt, D. Hörstermann, W. Hänicke, H. Bruhn, J. Frahm, Molecular self-diffusion of intracellular metabolites in rat brain in vivo investigated by localized proton NMR diffusion spectroscopy. Magn. Reson. Med. 29, 125-129 (1993).
14. S. Posse, C. A. Cuenod, D. Le Bihan, Human brain: proton diffusion MR spectroscopy. Radiology 188, 719-725 (1993).
15. M. Wick, Y. Nagatomo, F. Prielmeier, J. Frahm, Alteration of intracellular metabolite diffusion in rat brain in vivo during ischemia and reperfusion. Stroke 26, 1930-1934 (1995).
16. C. T. W. Moonen, P. Van Gelderen, P. C. M. Van Zijl, D. DesPres, A. Olson, The translational mobility of N-Acetyl-Aspartate in cat brain measured by localized proton NMR diffusion spectroscopy, in "Proc., SMR, 10th Annual Meeting, San Francisco, 1991," p. 141.
17. C. T. W. Moonen, P. C. M. van Zijl, J. Gillen, P. Daly, M. Von Kienlin, J. Wolf, J. Cohen, Comparison of single-shot localization methods (STEAM and PRESS) for in vivo proton NMR spectroscopy. NMR Biomed. 2, 201-208 (1989).
18. P. A. Bottomley, Spatial localization in NMR spectroscopy in vivo. Ann. N.Y. Acad. Sci. 508, 333-348 (1987).
19. R. J. Ordidge, M. R. Bendall, R. E. Gordon, A. Connelly, in "Magnetic Resonance in Medicine and Biology" (G. Govil, C.L. Khetrapal, A. Saran), pp. 387-397, Tata McGraw-Hill, New Delhi, 1985.
20. K. Luby-Phelps, D. L. Taylor, F. Lanni, Probing the structure of cytoplasm. J. Cell Biol. 102, 2015-2022 (1986).
21. K. Luby-Phelps, P. E. Castle, D. L. Taylor, F. Lanni, Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells. Proc. Natl. Acad. Sci. USA 84, 4910-4913 (1987).
22. C. Nicholson, J. M. Phillips, Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. J. Physiol. 321, 225-257 (1981).
23. C. T. W. Moonen, J. Pekar, M. H. M. De Vleeschouwer, P. Van Gelderen, P. C. M. Van Zijl, D. DesPres, Restricted and anisotropic displacement of water in healthy cat brain and in stroke studied by NMR diffusion imaging. Magn. Reson. Med. 19, 327-332 (1991).
24. T. L. Chenevert, J. G. Pipe, Effect of bulk tissue motion on quantitative perfusion and diffusion magnetic resonance imaging. Magn. Reson. Med. 19, 261-265 (1991).
25. V. Waluch, W. G. Bradley, NMR even echo rephasing in slow laminar flow. J. Comp. Assist. Tomogr. 8, 594-598 (1984).
26. S. Brint, M. Jacewicz, M. Kiessling, J. Tanabe, W. Pulsinelli, Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries. J. Cereb. Blood Flow Metab. 8, 474-485 (1988).
27. J. Mao, T. H. Mareci, E. R. Andrew, Experimental study of optimal selective 180 radiofrequency pulses. J. Magn. Reson. 79, 1-10 (1988).
28. C. T. W. Moonen, P. C. M. Van Zijl, Highly effective water suppression for in vivo proton NMR spectroscopy (DRYSTEAM). J. Magn. Reson. 88, 28-41 (1990).
29. 1H NMR spectroscopy study, in "Proc., SMRM, 11th Annual Meeting, Berlin, 1992," p. 1215.
30. R. J. Andrews, Transhemispheric diaschisis, A review and comment. Stroke 22, 943-949 (1991).
31. T. L. Chenevert, J. A. Brunberg, J. G. Pipe, Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo. Radiology 177, 401-405 (1990).
32. H. Sakuma, Y. Nomura, K. Takeda, T. Tagami, T. Nakagawa, Y. Tamagawa, Y. Ishii, T. Tsukamoto, Adult and neonatal human brain: diffusional anisotropy and myelination with diffusion-weighted MR imaging. Radiology 180, 228-233 (1991).
33. O. Henriksen, E. S. Karnick, S. Rosenbaum, Apparent diffusion of metabolites in the human brain. A proton-MRS study, in "Proc., SMR, 3rd Annual Meeting, Nice, France, 1995," p. 1855.
34. 133Cs NMR. Magn. Reson. Med. 35, 329-335 (1995).
35. O. Henriksen, S. Rosenbaum, B. Sperling, G. Boysen, Increased NAA diffusion in ischemic human brain tissue, in "Proc., SMR, 3rd Annual Meeting, Nice, France, 1995," p. 137.
36. D. C. Chang, H. E. Rorschach, B. L. Nichols, C. F. Hazlewood, Implications of diffusion coefficient measurements for the structure of cellular water. Ann. N.Y. Acad. Sci. 204, 434-443 (1973).
37. D. Le Bihan, J. Delannoy, R. L. Levin, Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia. Radiology 171, 853-857 (1989).
38. J. H. Simpson, H. Y. Carr, Diffusion and nuclear spin relaxation in water. Phys. Rev. 111, 1201-1202 (1958).
39. E. Morikawa, M. D. Ginsberg, W. D. Dietrich, R. C. Duncan, S. Kraydieh, Globus, M. Y.-T., R. Busto, The significance of brain temperature in focal cerebral ischemia: histopathological consequences of middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 12, 380-389 (1992).
40. C. Beaulieu, P. S. Allen, Determinants of anisotropic water diffusion in nerves. Magn. Reson. Med. 31, 394-400 (1994).
41. L. L. Latour, K. Svoboda, P. P. Mitra, C. H. Sotak, Time-dependent diffusion of water in a biological model system. Proc. Natl. Acad. Sci. USA 91, 1229-1233 (1994).
42. E. Syková, J. Svoboda, J. Polak, A. Chvatal, Extracellular volume fraction and diffusion characteristics during progressive ischemia and terminal anoxia in the spinal cord of the rat. J. Cereb. Blood Flow Metab. 14, 301-311 (1994).
43. A. Van der Toorn, E. Syková, R. M. Dijkhuizen, I. Voříšek, L. Vargová, E. Škobisová, M. Van Lookeren-Campagne, T. Reese, K. Nicolay, Dynamic changes in water ADC, energy metabolism and extracellular space volume and tortuosity in neonatal rat brain during terminal anoxia. Magn. Reson. Med. 36, 52-60 (1996).
44. H. B. Verheul, R. Balazs, Berkelbach van der J. W. Sprenkel, C. A. F. Tulleken, K. Nicolay, Van Lookeren M. Campagne, Temporal evolution of NMDA-induced excitotoxicity in the neonatal rat brain measured with 1H nuclear magnetic resonance imaging. Brain Res. 618, 203-212 (1993).
45. H. B. Verheul, R. Balazs, J. W. Berkelbach van der Sprenkel, C. A. F. Tulleken, K. Nicolay, K. S. Tamminga, M. Van Lookeren Campagne, Comparison of diffusion-weighted MRI with changes in cell volume in a rat model of brain injury. NMR Biomed. 7, 96-100 (1994).
46. J. A. Helpern, R. J. Ordidge, R. A. Knight, The effect of cell membrane water permeability on the apparent diffusion coefficient of water in "Proc., SMRM, 11th Annual Meeting, Berlin, 1992," p. 1201.
47. S. Ogawa, T. M. Lee, Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn. Reson. Med. 14, 68-78 (1990).
48. J. Zhong, O. A. C. Petroff, J. W. Prichard, J. C. Gore, Changes in water diffusion and relaxation properties of rat cerebrum during status epilepticus. Magn. Reson. Med. 30, 241-246 (1993).
49. J. Zhong, R. P. Kennan, J. C. Gore, Effects of susceptibility variations on NMR measurements of diffusion. J. Magn. Reson. 95, 267-280 (1991).
50. 1H-containing metabolites in rat brain after focal ischemia. NMR Biomed. 8, 245-252 (1995).
51. G. D. Graham, A. M. Blamire, A. M. Howseman, D. L. Rothman, P. B. Fayad, L. M. Brass, O. A. C. Petroff, R. G. Shulman, J. W. Prichard, Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients. Stroke 23, 333-340 (1992).
52. H. Lanfermann, H. Kugel, W. Heindel, K. Herholz, W. D. Heiss, K. Lackner, Metabolic changes in acute and subacute cerebral infarctions: findings at proton MR spectroscopic imaging. Radiology 196, 203-210 (1995).
53. L. H. Monsein, V. P. Mathews, P. B. Barker, C. A. Pardo, S. J. Blackband, W. D. Whitlow, D. F. Wong, R. N. Bryan, Irreversible regional cerebral ischemia: serial MR imaging and proton MR spectroscopy in a nonhuman primat model. AJNR 14, 963-970 (1993).
54. D. Sappey-Marinier, G. Calabrese, H. P. Hetherington, S. N. G. Fisher, R. Deicken, Van C. Dyke, G. Fein, M. W. Weiner, Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities. Magn. Reson. Med. 26, 313-327 (1992).