메뉴 건너뛰기




Volumn 19, Issue 9-10, 1997, Pages 587-597

Immunomodulatory properties of antiviral acyclic nucleotide analogues: Cytokine stimulatory and nitric oxide costimulatory effects

Author keywords

Acyclic nucleotide analogues; Antiviral agents; Interleukin 10; Nitric oxide; Tumour necrosis factor

Indexed keywords

2,6 DIAMINO 9 (2 PHOSPHONOMETHOXYETHYL)PURINE; 9 [2 (PHOSPHONOMETHOXY)ETHYL]GUANINE; 9 [2 (PHOSPHONOMETHOXY)PROPYL] 2,6 DIAMINOPURINE; ADEFOVIR; ANTIVIRUS AGENT; CIDOFOVIR; TENOFOVIR; UNCLASSIFIED DRUG;

EID: 18144452428     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(97)00047-7     Document Type: Conference Paper
Times cited : (18)

References (55)
  • 1
    • 0028805193 scopus 로고
    • Inhibitory effect of nitric oxide on the replication of a murine retrovirus in vitro and in vivo
    • Akarid, K., Sinet, M., Desforges, B. & Gougerot-Pocidalo, M. A. (1995) Inhibitory effect of nitric oxide on the replication of a murine retrovirus in vitro and in vivo. J. Virol., 69, 7001-7014.
    • (1995) J. Virol. , vol.69 , pp. 7001-7014
    • Akarid, K.1    Sinet, M.2    Desforges, B.3    Gougerot-Pocidalo, M.A.4
  • 2
    • 0028006762 scopus 로고
    • IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages
    • Akridge, R. E., Oyafuso, L. K. & Reed, S. G. (1994) IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages. J. Immunol., 153, 5782-5789.
    • (1994) J. Immunol. , vol.153 , pp. 5782-5789
    • Akridge, R.E.1    Oyafuso, L.K.2    Reed, S.G.3
  • 3
    • 0023789117 scopus 로고
    • Cytokines induce an L-arginine-dependent effector system in nonmacrophage cells
    • Amber, I. J., Hibbs, J. B. Jr, Taintor, R. R. & Vavrin, Z. (1988) Cytokines induce an L-arginine-dependent effector system in nonmacrophage cells. J. Leukocyte Biol., 44, 58-65.
    • (1988) J. Leukocyte Biol. , vol.44 , pp. 58-65
    • Amber, I.J.1    Hibbs J.B., Jr.2    Taintor, R.R.3    Vavrin, Z.4
  • 4
    • 0027534661 scopus 로고
    • Differential antiherpes virus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: Potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine
    • Balzarini, J., Holý, A., Jindřich, J., Naesens, L., Snoeck, R., Schols, D. & De Clercq, E. (1993) Differential antiherpes virus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrob. Agents. Chemother., 37, 332-338.
    • (1993) Antimicrob. Agents. Chemother. , vol.37 , pp. 332-338
    • Balzarini, J.1    Holý, A.2    Jindřich, J.3    Naesens, L.4    Snoeck, R.5    Schols, D.6    De Clercq, E.7
  • 5
    • 0029989972 scopus 로고    scopus 로고
    • Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems
    • Balzarini, J., Aquaro, S., Perno, C. F., Witvrouw, M., Holý, A. & De Clercq, E. (1996) Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems. Biochem. Biophys. Res. Commun., 219, 337-341.
    • (1996) Biochem. Biophys. Res. Commun. , vol.219 , pp. 337-341
    • Balzarini, J.1    Aquaro, S.2    Perno, C.F.3    Witvrouw, M.4    Holý, A.5    De Clercq, E.6
  • 7
    • 0002084536 scopus 로고
    • Regulation of inducible nitric oxide synthase in macrophages by cytokines and microbial products
    • ed. Masihi, K. N., Marcel Dekker, New York
    • Bogdan, C., Röllinghoff, M., Vodovotz, Y., Xie, Q.-wen. & Nathan, C. (1994) Regulation of inducible nitric oxide synthase in macrophages by cytokines and microbial products, In Immunotherapy of Infections (ed. Masihi, K. N.), pp. 37-54. Marcel Dekker, New York..
    • (1994) Immunotherapy of Infections , pp. 37-54
    • Bogdan, C.1    Röllinghoff, M.2    Vodovotz, Y.3    Xie, Q.-Wen.4    Nathan, C.5
  • 9
    • 0029794617 scopus 로고    scopus 로고
    • The inhibition of HIV replication in monocytes by interleukin 10 is linked to inhibition of cell differentiation
    • Chang, J., Naif, H. M., Li, S., Jozwiak, R., HoShon, M. & Cunningham, A. L. (1996) The inhibition of HIV replication in monocytes by interleukin 10 is linked to inhibition of cell differentiation. AIDS Res. Hum. Retrovirus, 12, 1227-1236.
    • (1996) AIDS Res. Hum. Retrovirus , vol.12 , pp. 1227-1236
    • Chang, J.1    Naif, H.M.2    Li, S.3    Jozwiak, R.4    Hoshon, M.5    Cunningham, A.L.6
  • 10
    • 0029022494 scopus 로고
    • Kinetic interaction of the diphosphates of 9-(2-phosphonylmethoxyethyl)-adenine and other anti-HIV active purine congeners with HIV reverse trancriptase and human DNA polymerases α, β and γ
    • Cherrington, J. M., Allen, S. J. W., Bischofberger, N. & Chen, M. S. (1995) Kinetic interaction of the diphosphates of 9-(2-phosphonylmethoxyethyl)-adenine and other anti-HIV active purine congeners with HIV reverse trancriptase and human DNA polymerases α, β and γ. Antivir. Chem. Chemother., 6, 217-221.
    • (1995) Antivir. Chem. Chemother. , vol.6 , pp. 217-221
    • Cherrington, J.M.1    Allen, S.J.W.2    Bischofberger, N.3    Chen, M.S.4
  • 11
    • 0028236275 scopus 로고
    • Regulation of inducible nitric oxide synthase mRNA levels by LPS, IFN-γ, TGF-β and IL-10 in murine macrophage cell lines and rat peritoneal macrophages
    • Chesrown, S. E., Monnier, J., Visner, G. & Nick, H. S. (1994) Regulation of inducible nitric oxide synthase mRNA levels by LPS, IFN-γ, TGF-β and IL-10 in murine macrophage cell lines and rat peritoneal macrophages. Biochem. Biophys. Res. Commun., 200, 126-134.
    • (1994) Biochem. Biophys. Res. Commun. , vol.200 , pp. 126-134
    • Chesrown, S.E.1    Monnier, J.2    Visner, G.3    Nick, H.S.4
  • 12
    • 0027301937 scopus 로고
    • Induction of macrophage nitric oxide production by interferon-γ and tumor necrosis factor-α is enhanced by interleukin-10
    • Corradin, S. B., Fasel, N., Buchmüller-Rouiller, Y., Ransijn, A., Smith, J. & Mauël, J. (1993) Induction of macrophage nitric oxide production by interferon-γ and tumor necrosis factor-α is enhanced by interleukin-10. Eur. J. Immunol., 23, 2045-2048.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2045-2048
    • Corradin, S.B.1    Fasel, N.2    Buchmüller-Rouiller, Y.3    Ransijn, A.4    Smith, J.5    Mauël, J.6
  • 13
    • 0027258651 scopus 로고
    • Evidence for an antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication
    • Croen, K. D. (1993) Evidence for an antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication. J. Clin. Invest., 91, 2446-2452.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2446-2452
    • Croen, K.D.1
  • 15
    • 0029704912 scopus 로고    scopus 로고
    • Therapeutic potential of Cidofovir (HPMPC, Vistide) for the treatment of DNA virus (i.E. Herpes-, papova-, pox- and adenovirus) infections
    • De Clercq, E. (1996) Therapeutic potential of Cidofovir (HPMPC, Vistide) for the treatment of DNA virus (i.e. Herpes-, papova-, pox- and adenovirus) infections. Verh. K. Acad. Geneeskd. Belg., 58, 19-47.
    • (1996) Verh. K. Acad. Geneeskd. Belg. , vol.58 , pp. 19-47
    • De Clercq, E.1
  • 16
    • 0025834476 scopus 로고
    • Immunomodulatory activity of 9-(2-phosphonyl-methoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogueue, on in vivo murine models
    • Del Gobbo, V., Foli, A., Balzarini, J., De Clercq, E., Balestra, E., Villani, N., Marini, S., Perno, C. F. & Calio, R. (1991) Immunomodulatory activity of 9-(2-phosphonyl-methoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogueue, on in vivo murine models. Antiviral Res., 16, 65-75.
    • (1991) Antiviral Res. , vol.16 , pp. 65-75
    • Del Gobbo, V.1    Foli, A.2    Balzarini, J.3    De Clercq, E.4    Balestra, E.5    Villani, N.6    Marini, S.7    Perno, C.F.8    Calio, R.9
  • 18
    • 0029120117 scopus 로고
    • Interferon-gamma-induced downregulation of CD4 inhibits the entry of human immunodeficiency virus type-1 in primary monocytes
    • Dhawan, S., Heredia, A., Wahl, L. M., Epstein, J. S., Meltzer, M. S. & Hewlett, I. K. (1995) Interferon-gamma-induced downregulation of CD4 inhibits the entry of human immunodeficiency virus type-1 in primary monocytes. Pathobiology, 63, 93-99.
    • (1995) Pathobiology , vol.63 , pp. 93-99
    • Dhawan, S.1    Heredia, A.2    Wahl, L.M.3    Epstein, J.S.4    Meltzer, M.S.5    Hewlett, I.K.6
  • 19
    • 0028844676 scopus 로고
    • An elusive soluble suppressor
    • Fauci, A. S. (1995) An elusive soluble suppressor. Nature, 378, 561.
    • (1995) Nature , vol.378 , pp. 561
    • Fauci, A.S.1
  • 21
    • 0028233759 scopus 로고
    • Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates
    • Gong, Y. -F., Marshall, D. R., Srinivas, R. V. & Fridland, A. (1994) Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates. Antimicrob. Agents. Chemother., 38, 1683-1687.
    • (1994) Antimicrob. Agents. Chemother. , vol.38 , pp. 1683-1687
    • Gong, Y.-F.1    Marshall, D.R.2    Srinivas, R.V.3    Fridland, A.4
  • 22
    • 0028130055 scopus 로고
    • Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis b virus and duck hepatitis B virus infections in tissue culture
    • Heijtink, R. A., Kruining, J., de Wilde, G. A., Balzarini, J., De Clercq, E. & Schalm, S. W. (1994) Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture. Antimicrob. Agents. Chemother., 38, 2180-2182.
    • (1994) Antimicrob. Agents. Chemother. , vol.38 , pp. 2180-2182
    • Heijtink, R.A.1    Kruining, J.2    De Wilde, G.A.3    Balzarini, J.4    De Clercq, E.5    Schalm, S.W.6
  • 23
    • 0026755636 scopus 로고
    • Cellular metabolism and enzymatic phosphorylation of 9-(2-phosphonylmethoxyethyl) guanine (PMEG), a potent antiviral agent
    • Ho, H. T. Woods, K. L., Konrad, S. A., De Boeck, H. & Hitchcock, M. J. (1992) Cellular metabolism and enzymatic phosphorylation of 9-(2-phosphonylmethoxyethyl) guanine (PMEG), a potent antiviral agent. Adv. Exp. Med. Biol., 312, 159-166.
    • (1992) Adv. Exp. Med. Biol. , vol.312 , pp. 159-166
    • Ho, H.T.1    Woods, K.L.2    Konrad, S.A.3    De Boeck, H.4    Hitchcock, M.J.5
  • 24
    • 21844495129 scopus 로고
    • Synthesis of enantiomeric 9-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. 1. Stepwise approach
    • Holý, A. & Masojidková, M. (1995) Synthesis of enantiomeric 9-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. 1. Stepwise approach. Collect. Czech. Chem. Commun., 60, 1196-1212.
    • (1995) Collect. Czech. Chem. Commun. , vol.60 , pp. 1196-1212
    • Holý, A.1    Masojidková, M.2
  • 25
    • 0010472244 scopus 로고
    • Synthesis of 3-hydroxy-2-phosphonylmethoxypropylderivatives of heterocyclic bases
    • Holý, A., Rosenberg, I. & Dvořáková, H. (1989) Synthesis of 3-hydroxy-2-phosphonylmethoxypropyl)derivatives of heterocyclic bases. Collect. Czech. Chem. Commun., 54, 2470-2501.
    • (1989) Collect. Czech. Chem. Commun. , vol.54 , pp. 2470-2501
    • Holý, A.1    Rosenberg, I.2    Dvořáková, H.3
  • 27
    • 0028843980 scopus 로고
    • Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-α and IL-6 release by endotoxin-stimulated macrophages
    • Kambayashi, T., Jacob, C. O., Zhou, D., Mazurek, M., Fong, M. & Strassmann, G. (1995) Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-α and IL-6 release by endotoxin-stimulated macrophages. J. Immunol., 155, 4909-4916.
    • (1995) J. Immunol. , vol.155 , pp. 4909-4916
    • Kambayashi, T.1    Jacob, C.O.2    Zhou, D.3    Mazurek, M.4    Fong, M.5    Strassmann, G.6
  • 28
    • 0027488067 scopus 로고
    • Inhibition of viral replication by interferon-γ-induced nitric oxide synthase
    • Karupiah, G., wen Xie, Q., Buller, R. M. L., Nathan, C., Duarte, C. & MacMicking, J. D. (1993) Inhibition of viral replication by interferon-γ-induced nitric oxide synthase. Science, 261, 1445-1448.
    • (1993) Science , vol.261 , pp. 1445-1448
    • Karupiah, G.1    Wen Xie, Q.2    Buller, R.M.L.3    Nathan, C.4    Duarte, C.5    MacMicking, J.D.6
  • 29
    • 0028075890 scopus 로고
    • Interference of IL-10 with HIV-1 replication in primary monocyte derived macrophages
    • Kootstra, N. A., vant Wout, A. B., Huisman, J. G., Miedema, F. & Schuitemaker, H. (1994) Interference of IL-10 with HIV-1 replication in primary monocyte derived macrophages. J. Virol., 68, 6967-6975.
    • (1994) J. Virol. , vol.68 , pp. 6967-6975
    • Kootstra, N.A.1    Vant Wout, A.B.2    Huisman, J.G.3    Miedema, F.4    Schuitemaker, H.5
  • 30
    • 0029941879 scopus 로고    scopus 로고
    • Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogues toward DNA polymerases α, δ and ∈
    • Kramata, P., Votruba, I., Otová, B. & Holý, A. (1996) Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogues toward DNA polymerases α, δ and ∈. Mol. Pharmacol., 49, 1005-1011.
    • (1996) Mol. Pharmacol. , vol.49 , pp. 1005-1011
    • Kramata, P.1    Votruba, I.2    Otová, B.3    Holý, A.4
  • 31
    • 0025302793 scopus 로고
    • Treatment of latent rabbit and human papillomavirus infections with 9-(2-phosphonylmethoxy)ethyl-guanine (PMEG)
    • Kreider, J. W., Balogh, K., Olson, R. O. & Martin, J. C. (1990) Treatment of latent rabbit and human papillomavirus infections with 9-(2-phosphonylmethoxy)ethyl-guanine (PMEG). Antiviral. Res., 14, 51-58.
    • (1990) Antiviral. Res. , vol.14 , pp. 51-58
    • Kreider, J.W.1    Balogh, K.2    Olson, R.O.3    Martin, J.C.4
  • 33
    • 0026095439 scopus 로고
    • Inhibitory effect of acyclic nucleoside phosphonate analogues, including (S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl)cytosine, on Epstein-Barr virus replication
    • Lin, J. C., De Clercq, E. & Pagano, J. S. (1991) Inhibitory effect of acyclic nucleoside phosphonate analogues, including (S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl)cytosine, on Epstein-Barr virus replication. Antimicrob. Agents. Chemother., 35, 2440-2443.
    • (1991) Antimicrob. Agents. Chemother. , vol.35 , pp. 2440-2443
    • Lin, J.C.1    De Clercq, E.2    Pagano, J.S.3
  • 34
    • 0027957155 scopus 로고
    • Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor
    • Lucin, P., Jonjic, S., Messerle, M., Polic, B., Hengel, H. & Koszinowski, U. H. (1994) Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor. J. Gen. Virol., 75, 101-110.
    • (1994) J. Gen. Virol. , vol.75 , pp. 101-110
    • Lucin, P.1    Jonjic, S.2    Messerle, M.3    Polic, B.4    Hengel, H.5    Koszinowski, U.H.6
  • 37
    • 0026528309 scopus 로고
    • Interferon-gamma-induced assembly bloc in the replication cycle of adenovirus 2: Augmentation by tumor necrosis factor-alpha
    • Mayer, A., Gelderblom, H., Kumel, G. & Jungwirth, C. (1992) Interferon-gamma-induced assembly bloc in the replication cycle of adenovirus 2: augmentation by tumor necrosis factor-alpha. Virology, 187, 372-376.
    • (1992) Virology , vol.187 , pp. 372-376
    • Mayer, A.1    Gelderblom, H.2    Kumel, G.3    Jungwirth, C.4
  • 38
    • 0029980269 scopus 로고    scopus 로고
    • Differential regulation of monocytic tumor necrosis factor-α and interleukin-10 expression
    • Meisel, C., Vogt, K., Platzer, C., Randow, F., Liebenthal, C. & Volk, H. -D. (1996) Differential regulation of monocytic tumor necrosis factor-α and interleukin-10 expression. Eur. J. Immunol., 26, 1580-1586.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1580-1586
    • Meisel, C.1    Vogt, K.2    Platzer, C.3    Randow, F.4    Liebenthal, C.5    Volk, H.-D.6
  • 39
  • 41
    • 0028560018 scopus 로고
    • Therapeutic potential of PMEA as an antiviral drug
    • Naesens, L., Balzarini, J. & De Clercq, E. (1994b) Therapeutic potential of PMEA as an antiviral drug. Rev. Med. Virol., 4, 147-159.
    • (1994) Rev. Med. Virol. , vol.4 , pp. 147-159
    • Naesens, L.1    Balzarini, J.2    De Clercq, E.3
  • 42
    • 0026629902 scopus 로고
    • Nitric oxide as a secretory product of mammalian cells
    • Nathan, C. (1992) Nitric oxide as a secretory product of mammalian cells. FASEB JI, 6, 3051-3064.
    • (1992) FASEB JI , vol.6 , pp. 3051-3064
    • Nathan, C.1
  • 43
    • 9444293982 scopus 로고    scopus 로고
    • Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines
    • Perno, C. F., Balestra, S., Aquaro, S., Panti, S., Cenci, A., Lazzarino, G., Tavazzi, B., Dipierro, D., Balzarini, J. & Calio, R. (1996) Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines. Mol. Pharmacol., 50, 359-366.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 359-366
    • Perno, C.F.1    Balestra, S.2    Aquaro, S.3    Panti, S.4    Cenci, A.5    Lazzarino, G.6    Tavazzi, B.7    Dipierro, D.8    Balzarini, J.9    Calio, R.10
  • 44
    • 0026026407 scopus 로고
    • Transforming growth factor β suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage
    • Poli, G., Kinter, A. L., Justement, J. S., Bressler, P., Kehrl, J. H. & Fauci, A. S. (1991) Transforming growth factor β suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. J. exp. Med., 173, 589-597.
    • (1991) J. Exp. Med. , vol.173 , pp. 589-597
    • Poli, G.1    Kinter, A.L.2    Justement, J.S.3    Bressler, P.4    Kehrl, J.H.5    Fauci, A.S.6
  • 46
    • 0029915543 scopus 로고    scopus 로고
    • Inhibition of TNF-α expression by adenosine: Role of A3 adenosine receptors
    • Sajjadi, F. G., Tabayashi, K., Foster, A. C., Domingo, R. C. & Firestein, G. S. (1996) Inhibition of TNF-α expression by adenosine: role of A3 adenosine receptors. J. Immunol., 156, 3435-3442.
    • (1996) J. Immunol. , vol.156 , pp. 3435-3442
    • Sajjadi, F.G.1    Tabayashi, K.2    Foster, A.C.3    Domingo, R.C.4    Firestein, G.S.5
  • 47
    • 0028340875 scopus 로고
    • Interleukin-10 suppresses human immunodeficiency virus-1 replication in vitro in cells of the monocyte/macrophage lineage
    • Saville, M. W., Taga, K., Foli, A., Broder, S., Tosato, G. & Yarchoan, R. (1994) Interleukin-10 suppresses human immunodeficiency virus-1 replication in vitro in cells of the monocyte/macrophage lineage. Blood, 83, 3591-3599.
    • (1994) Blood , vol.83 , pp. 3591-3599
    • Saville, M.W.1    Taga, K.2    Foli, A.3    Broder, S.4    Tosato, G.5    Yarchoan, R.6
  • 49
    • 0028942187 scopus 로고
    • Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: A model for in vivo testing of candidate anti-human immunodeficiency virus drugs
    • Thormar, H., Georgsson, G., Palsson, P. A., Balzarini, J., Naesens, L., Torsteinsdottir, S., De Clercq, E. (1995) Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs. Proc. natl. Acad. Sci. U.S.A., 92, 3283-3287.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 3283-3287
    • Thormar, H.1    Georgsson, G.2    Palsson, P.A.3    Balzarini, J.4    Naesens, L.5    Torsteinsdottir, S.6    De Clercq, E.7
  • 52
    • 0028169781 scopus 로고
    • 9-(2-phosphonylmethoxyethyl)adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system
    • Villani, N., Calio, R., Balestra, E., Balzarini, J., De Clercq, E., Fabrizi, E., Perno, C. F. & Del Gobbo, V. (1994) 9-(2-phosphonylmethoxyethyl)adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system. Antiviral Res., 25, 81-89.
    • (1994) Antiviral Res. , vol.25 , pp. 81-89
    • Villani, N.1    Calio, R.2    Balestra, E.3    Balzarini, J.4    De Clercq, E.5    Fabrizi, E.6    Perno, C.F.7    Del Gobbo, V.8
  • 53
    • 0025336166 scopus 로고
    • Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues
    • Votruba, I., Trávníček, M., Rosenberg, I., Otmar, M., Merta, A., Hřebabecký, H. & Holý, A. (1990) Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues. Antiviral Res., 13, 287-293.
    • (1990) Antiviral Res. , vol.13 , pp. 287-293
    • Votruba, I.1    Trávníček, M.2    Rosenberg, I.3    Otmar, M.4    Merta, A.5    Hřebabecký, H.6    Holý, A.7
  • 54
    • 0025985990 scopus 로고
    • Prolonged and potent therapeutic and phrophylactic effects of (S)-1-[(3-hydroxy-2-phosphonylmethoxy)propyl]-cytosine against herpes simplex virus type 2 infections in mice
    • Yang, H. & Datema, R. (1991) Prolonged and potent therapeutic and phrophylactic effects of (S)-1-[(3-hydroxy-2-phosphonylmethoxy)propyl]-cytosine against herpes simplex virus type 2 infections in mice. Antimicrob. Agents. Chemother., 35, 1596-1600.
    • (1991) Antimicrob. Agents. Chemother. , vol.35 , pp. 1596-1600
    • Yang, H.1    Datema, R.2
  • 55
    • 0343144794 scopus 로고    scopus 로고
    • Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production
    • Zídek, Z., Holý, A. & Franková, D. (1997). Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production. Eur. J. Pharmacol., 331, 245-252.
    • (1997) Eur. J. Pharmacol. , vol.331 , pp. 245-252
    • Zídek, Z.1    Holý, A.2    Franková, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.