Therapeutic effect of D-002 (abexol) on gastric ulcer induced experimentally in rats

Journal of Medicinal Food

Volumn 8, Issue 1, 2005, Pages 59-62

  Molina, Vivian ^a   Carbajal, Daisy ^a   Arruzazabala, Lourdes ^a   Más, Rosa ^a  

^a NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

Author keywords

D 002; Gastric ulcer; Therapeutic effect

Indexed keywords

ABEXOL; ACETIC ACID; ALCOHOL DERIVATIVE; ANTIULCER AGENT; D 002; DOTRIACONTANOL; HEXACOSANOL; INDOMETACIN; OCTACOSANOL; PROPOLIS; TETRACOSANOL; TETRATRIACONTANOL; TRIACONTANOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; FEMALE; HONEYBEE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER; ULCER HEALING;

ACETIC ACID; ACUTE DISEASE; ADMINISTRATION, ORAL; ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ALCOHOLS; FEMALE; INDOMETHACIN; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER; TREATMENT OUTCOME;

ANIMALIA; APIS MELLIFERA; PROPOLIS;

EID: 18144401657     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2005.8.59     Document Type: Article

References (19)

1. Magraner J, Laguna A, Más R, Carbajal D, Arruzazabala ML, Díaz M, Molina V, Valdés S: Una mezcla natural compuesta por alcoholes alifáticos primarios obtenido de la cera de abejas para el tratamiento de las úlceras gástricas y duodenales que presenta también actividad antiinflammatoria. Cuba Patente CU 22412. February 8, 1995.
2. Carbajal D, Molina V, Valdes S, Arruzazabala L, Mas R: Anti-ulcer activity of higher primary alcohols of beeswax. J Pharm Pharmacol 1995;47:731-733.
3. Carbajal D, Molina V, Valdes S, Arruzazabala L, Rodeiro I, Mas R, Magraner J: Possible cytoprotective mechanism in rats of D-002, an anti-ulcerogenic product isolated from beeswax. J Pharm Pharmacol 1996;48:858-860.
4. Carbajal D, Molina V, Noa M, Valdes S, Arruzazabala ML, Aguilar C, Mas R: Effect of D-002 on gastric mucus composition in ethanol-induced ulcer. Phannacol Res 2000;42:329-332.
5. Molina V, Valdés S, Carbajal D, Arruzazabala L, Menéndez R, Más R: Antioxidant effect of D-002 on gastric mucosa of rats with experimentally induced injury. J Med Food 2001;4:79-83.
6. Menéndez R, Amor AM, Gonzalez RM, Jiménez S, Más R: Inhibition of rat microsomal lipid peroxidation by the oral administration of D002. Braz J Med Biol Res 2000;33:85-90.
7. Menéndez R, Mas R, Amor AM, Perez Y, González RM, Fernandez JC, Jiménez S: Antioxidant effect of D-002 on the in vitro susceptibility of whole plasma in healthy volunteers. Arch Med Rev 2001;32:436-441.
8. Menéndez R, Más R, Illnait J, Perez J, Amor AM, Fernandez JC, Gonzalez RM: Effects of D-002 on lipid peroxidation in older subjects. J Med Food 2001;4:71-77.
9. D'Souza RS, Dhume VG: Gastric cytoprotection. Indian J Physiol Pharmacol 1991;35:88-98.
10. Chao JC, Hung HC, Chen SH, Fang CL: Effects of Ginkgo biloba extract on cytoprotective factors in rats with duodenal ulcer. World J Gastroenterol 2004;15:560-566.
11. Hano O, Illnait J, Mas R, Fernández L, Piñol F, Fernández J: Effects of D-002, a product isolated from beeswax, on duodenal ulcer: A double-blind, placebo-controlled study. Curr Ther Res 2001;62:394-407.
12. Segawa Y, Omata T, Abe T, Tsuzuike N, Itokazu Y, Yoshida K, Ueda I: Effect of a new non-steroidal anti-inflammatory combination of a histamine H2 antagonist and indomethacin on gastroduodenal mucosal membrane in rat. Arzneimittelforschung 1992;42:1232-1235.
13. Okabe S, Roth IL: A method for experimental penetrating gastric and duodenal ulcers in rats. Digestion 1987;38:103-113.
14. Ohara A, Sugiyama S, Hoshino H, Hamajima E, Goto H, Tsukamoto Y, Osawa T: Reduction of adverse effects of indomethacin by anti-allergic drugs in rat stomachs. Arzneimittelforschung 1992;42:1115-1118.
15. Kapui Z, Boer K, Rozsa I, Blasco G, Hermecz I: Investigations of indomethacin-induced gastric ulcer in rats. Arzneimittelforschung 1993;43:767-771.
16. Katsuya Y, Hironobu I, Takashi I: Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer and gastric secretion in rats. Jpn J Pharmacol 1989;49:441-448.
17. Kasanori Y: Cytoprotective antiulcerogenic actions of hydroxychalcones in rats. Planta Med 1992;58:389-393.
18. Luo JC, Shin VY, Liu ES, Ye YN, Wu WK, So WH, Chang FY, Cho CH: Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs. Eur J Pharmacol 2004;485:275-281.
19. Amagase K, Yokota M, Tsukimi Y, Okabe S: Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. J Physiol Pharmacol 2003;54:349-360.