Clinicopathological features of hepatocellular carcinomas (HCCs) arising in patients without chronic viral infection or alcohol abuse: A retrospective study of patients undergoing hepatic resection

Journal of Gastroenterology

Volumn 40, Issue 3, 2005, Pages 274-282

  Yokoi, Yoshihiro ^a,b   Suzuki, Shohachi ^b   Baba, Satoshi ^b   Inaba, Keisuke ^b   Konno, Hiroyuki ^b   Nakamura, Satoshi ^b  

^a Hamamatsu Social Insurance Hospital   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hepatocellular carcinoma; Intrahepatic recurrences; Non B non C non alcoholic; Repeat hepatic resection

Indexed keywords

ALPHA FETOPROTEIN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS C ANTIBODY; INDOCYANINE GREEN;

ADULT; AGED; ALCOHOLISM; ARTICLE; CANCER DIAGNOSIS; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HEPATITIS B; HEPATITIS C; HEPATITIS G; HISTOPATHOLOGY; HUMAN; LIVER CELL CARCINOMA; LIVER FIBROSIS; LIVER FUNCTION; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RETROSPECTIVE STUDY; SERODIAGNOSIS; VIRUS INFECTION;

ADULT; AGED; AGED, 80 AND OVER; ALCOHOLISM; ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; CHRONIC DISEASE; DISEASE-FREE SURVIVAL; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; HEPACIVIRUS; HEPATECTOMY; HEPATITIS B ANTIGENS; HEPATITIS B VIRUS; HEPATITIS C ANTIBODIES; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE PERIOD; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL RATE; TREATMENT OUTCOME; VIRUS DISEASES;

EID: 18144380322     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00535-004-1536-1     Document Type: Article

References (45)

1. El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999;340:745-50.
2. Bosch X, Ribes J, Borras J. Epidemiology of primary liver cancer. Semin Liver Dis 1999;19:271-85.
3. Okuda K, Fujimoto I, Hanai A, Urano Y. Changing incidence of hepatocellular carcinoma in Japan. Cancer Res 1987;47:4967-72.
4. Johnson PJ, Williams R. Cirrhosis and the aetiology of hepatocellular carcinoma. J Hepatol 1987;4:150-7.
5. Ikeda K, Saitoh S, Koida I, Arase Y, Tsubota A, Chayama K, et al. A multivariate analysis of risk factors for hepatocellular carcinoma: A prospective observation of 795 patients with viral and alcoholic cirrhosis. Hepatology 1993;18:47-53.
6. Takenaka K, Yamamoto K, Taketomi A, Itasaka H, Adachi E, Shirabe K, et al. A comparison of the surgical results in patients with hepatitis B versus hepatitis C-related hepatocellular carcinoma. Hepatology 1995;22:20-4.
7. Shiratori Y, Shiina S, Imamura M, Kata N, Kanai F, Okudaira T, et al. Characteristic difference of hepatocellular carcinoma between hepatitis B- and C- viral infection in Japan. Hepatology 1995;22:1027-33.
8. Miyagawa S, Kawasaki S, Makuuchi M. Comparison of the characteristics of hepatocellular carcinoma between hepatitis B and C viral infection: tumor multicentricity in cirrhotic liver with hepatitis C. Hepatology 1996;24:307-10.
9. Yamanaka N, Tanaka T, Tanaka W, Yamanaka J, Yasui C, Kuroda N, et al. Correlation of hepatitis virus serologic status with clinicopathologic features in patients undergoing hepatectomy for hepatocellular carcinoma. Cancer 1997;79:1509-15.
10. Wu CC, Ho WL, Chen JT, Tang JS, Yeh DC, P'eng FK. Hepatitis viral status in patients undergoing liver resection for hepatocellular carcinoma. Br J Surg 1999;86:1391-6.
11. Shiraishi M, Hiroyasu S, Nagahama M, Tomita S, Miyahara T, Kusano T, et al. Chacteristics of hepatocellular carcinoma with negative virus markers: Clinicopathological study of resected tumors. World J Surg 1999;23:301-5.
12. Kubo S, Nishiguchi S, Hirohashi K, Tanaka H, Tsukamoto T, Hamba H, et al. High prevalence of infection with hepatitis B and C viruses in patients with hepatocellular carcinoma in Japan. Hepatogastroenterology 1999;46:357-9.
13. Noguchi K, Nakashima O, Nakashima Y, Shirota K, Nawata H, Kojiro M. Clinicopathological study on hepatocellular carcinoma negative for hepatitis B surface antigen and antibody to hepatitis C virus. Int J Mol Med 2000;6:661-5.
14. Koike Y, Shiratori Y, Sato S, Obi S, Taratani T, Imamura M, et al. Risk factors for recurring hepatocellular carcinoma differ according to infected hepatitis virus - an analysis of 236 consecutive patients with a single lesion. Hepatology 2000;32:1216-23.
15. Yotsuyanagi H, Shintani Y, Moriya K, Fujie H, Tsutsumi T, Kato T, et al. Virologic analysis of non-B non-C hepatocellular carcinoma in Japan: frequent involvement of hepatitis B virus. J Infect Dis 2000;181:1920-8.
16. Urashima T, Saigo K, Kobayashi S, Imaseki H, Matsubara H, Koide Y, et al. Identification of hepatitis B virus integration in hepatitis C virus-infected hepatocellular carcinoma tissues. J Hepatol 1997;26:771-8.
17. Alter HJ. The cloning and clinical implications of HGV and GBV-C. N Engl J Med 1996;334:1536-7.
18. Tamori A, Nishiguchi S, Kubo S, Koh N, Moriyama Y, Fujimoto S, et al. Possible contribution to hepatocarcinogenesis of X transcript of hepatitis B virus in Japanese patients with hepatitis C virus. Hepatology 1999;29:1429-34.
19. Ohana M, Hajiro K, Takakuwa H, Okazaki K. Clinical features of serologically non-B non-C chronic liver disease. Hepatogastroenterology 1997;44:215-20.
20. Kodali VP, Gordon SC, Silverman AL, McCray D. Cryptogenic liver disease in the United States: Further evidence for non-A, non-B, and non-C hepatitis. Am J Gastroenterol 1994;89:1836-9.
21. Kamiya K, Suzuki S, Sakaguchi T, Konno H, Baba S, Nakamura S, et al. Hepatectomy for hepatocellular carcinoma in a renal transplant patient. Report of a case and literature review. Hepatogastroenterology 2000;47:835-8.
22. Liver Cancer Study Group of Japan. The general rules for the clinical and pathological study of primary liver cancer (in Japanese). 4th ed. Tokyo: Kanehara; 2000. p. 1-68.
23. Edmondson HA, Steiner PE. Primary carcinoma of the liver: A study of 100 cases among 49 800 necropsies. Cancer 1954;7:462-503.
24. De Groote J, Desmet VJ, Gerigk P, Korb G, Popper H, Poulsen H, et al. A classification of chronic hepatitis. Lancet 1968;1:626-8.
25. Desmet V, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis; diagnosis, grading, and staging. Hepatology 1994;19:1513-20.
26. Tanaka M, Nishiguchi S, Tanaka T, Enomoto M, Fukuda K, Takeda T, et al. Prevalence of GBV-C and hepatitis G virus variants in patients with fulminant hepatic failure in Japan. J Hepatol 1997:27:966-72.
27. Child CG, Turcotte JG. Surgery and portal hypertension. In: Child CG, editor. The liver and portal hypertension. Philadelphia: WB Saunders; 1964. p. 49-51.
28. Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-9.
29. Kew MC, Popper H. Relationship between hepatocellular carcinoma and cirrhosis. Semin Liver Dis 1984;4:136-46.
30. Alpert ME, Hutt MS, Wogan GN, Davidson CS. Association between aflatoxin content of food and hepatoma frequency in Uganda. Cancer 1971;28:253-60.
31. Paterlini P, Gerken G, Nakajima E, Terre S, D'Errico A, Grigioni B, et al. Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen. New Engl J Med 1990;323:80-5.
32. The Liver Cancer Study Group of Japan. Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. Cancer 1994;74:2772-80.
33. Yuki K, Hirohashi S, Sakamoto M, Kanai T, Shimosato Y. Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases. Cancer 1990;66:2174-9.
34. Rua S, Comino A, Fruttero A, Torchio P, Bouzari H, Taraglio S, et al. Flow cytometric DNA analysis of cirrhotic liver cells in patients with hepatocellular carcinoma can provide a new prognostic factor. Cancer 1996;78:1195-202.
35. Yamanaka N, Okamoto E, Toyosaka A, Mitunobu M, Fujihata S, Kato T, et al. Prognostic factors after hepatectomy for hepatocellular carcinomas: a univariate and multivariate analysis. Cancer 1990:65:1104-10.
36. The Liver Cancer Study Group of Japan. Primary liver cancer in Japan: clinicopathologic features and results of surgical treatment. Ann Surg 1990;211:277-87.
37. Nagasue N, Yukaya H, Ogawa Y, Sasaki Y, Chang YC, Niimi K. Second hepatic resection for recurrent hepatocellular carcinoma. Br J Surg 1986;73:434-8.
38. Matsuda Y, Ito T, Oguchi Y, Nakajima K, Izukura T. Rationale of surgical management for recurrent hepatocellular carcinoma. Ann Surg 1993;217:28-34.
39. Tarao K, Rino Y, Ohsawa S, Tamai S, Miyakawa T, Takakura H, et al. Close association between high serum alanine aminotransferase levels and multicentric hepatocarcinogenesis in patients with hepatitis C virus-associated cirrhosis. Cance 2002;94:1878-95.
40. Poon RTP, Fan ST, Lo CM, Liu CL, Wong J. Intrahepatic recurrence after curative resection of hepatocellular carcinoma. Long-term results of treatment and prognosis factors. Ann Surg 1999;229:216-22.
41. Okusaka T, Okada S, Nose H, Ishii H, Nakasuka H, Nakayama H, et al. The prognosis of patients with hepatocellular carcinoma of multicentric origin. Hepatogastroenterology 1996;43:919-25.
42. Arii S, Monden K, Niwano M, Furutani M, Mori A, Mizumoto M, et al. Results of surgical treatment for recurrent hepatocellular carcinoma; comparison of outcome among patients with multicentric carcinogenesis, intrahepatic metastasis, and extrahepatic recurrence. J Hepatobiliary Pancreat Surg 1998;5:86-92.
43. Majno PE, Sarasin FP, Mentha G, Hadengue A. Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: An outcome-orientated decision analysis. Hepatology 2000;31:899-906.
44. Poon RTP, Fan ST, Lo CM, Liu CL, Wong J. Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function. Implications for a strategy of salvage transplantation. Ann Surg 2002;235:373-82.
45. Adam R, Azoulay D, Castaing D, Eshkenazy R, Pascal G, Hashizume K, et al. Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis. A reasonable strategy? Ann Surg 2003;238:508-19.