IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivity

British Journal of Haematology

Volumn 115, Issue 3, 2001, Pages 679-686

  Crow, Andrew R ^a,b   Song, Seng ^a   Semple, John W ^a   Freedman, John ^a,b   Lazarus, Alan H ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b CANADIAN BLOOD SERVICES   (Canada)

Author keywords

Anti idiotype; IVIg; Mouse; Platelet; Thrombocytopenia

Indexed keywords

IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY;

ADSORPTION; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; ERYTHROCYTE; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADSORPTION; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; FEMALE; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULINS, INTRAVENOUS; MICE; MICE, SCID; MODELS, ANIMAL; PLATELET COUNT; RETICULOENDOTHELIAL SYSTEM; STATISTICS, NONPARAMETRIC; THROMBOCYTOPENIA;

EID: 0035669179     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.03136.x     Document Type: Article

References (44)

1. Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model
2. New therapeutic avenues in autoimmunity
3. Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia
4. Inhibition of autoantibody binding to platelet glycoprotein IIb/IIIa by anti-idiotypic antibodies in intravenous gammaglobulin
5. Autoimmune thrombocytopenia: Anti-glycoprotein IIb/IIIa auto antibodies are reduced after human anti-D immunoglobulin treatment
6. Modulation of Fc receptor clearance and antiplatelet antibodies as a consequence of intravenous globulin infusion in patients with immune thrombocytopenic purpura
7. Isolated thrombocytopenia in patients infected with HIV: Treatment with intravenous immunoglobulin
8. Intravenous gammaglobulin treatment of chronic idiopathic thrombocytopenic purpura
9. A comparative analysis of cDNA-derived sequences for rat and mouse β3 integrins (GPIIIA) with their human counterpart
10. High dose intravenous immunoglobulin therapy for rheumatic diseases: Clinical relevance and personal experience
11. Normal immunoglobulin G (IgG) for therapeutic use (intravenous Ig) contain antiidiotypic specificities against an immunodominant, disease-associated, cross-reactive idiotype of human anti-thyroglobulin autoanti-bodies
12. Manipulating the immune system with immune globulin
13. Monoclonal antibody 197 (anti-FcγRI) infusion in a patient with immune thrombocytopenia purpura (ITP) results in down-modulation of FcγRI on circulating monocytes
14. Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis
15. Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous immunoglobulin
16. Platelet-reactive IgG antibodies cloned by phage display and panning with IVIG from three patients with autoimmune thrombocytopenia
17. Correction of severe heparin-associated thrombocytopenia with intravenous immunoglobulin
18. Use of intravenous immunoglobulin to delay xenogeneic hyperacute rejection. An in vivo and in vitro evaluation
19. Extracellular mutations of non-obese diabetic mouse FcγRI modify surface expression and ligand binding
20. Gain-of-function mutations in FcγRI of NOD mice: Implications for the evolution of the Ig superfamily
21. Suppression of HLA-specific alloantibodies by high-dose intravenous immunoglobulins (IVIg)
22. Treatment of adult chronic autoimmune thrombocytopenic purpura with repeated high-dose intravenous immunoglobulin
23. Normal polyspecific immunoglobulin G (IVIg) in the treatment of autoimmune diseases
24. High-dose intravenous immunoglobulin for idiopathic thrombo-cytopenic purpura in childhood
25. An evaluation of intravenous immunoglobulin in the treatment of human immunodeficiency virus-associated thrombocytopenia
26. Prolonged remission of SLE-associated polyradiculoneuropathy after a single course of intravenous immunoglobulin
27. Novel cross-reactive anti-idiotype antibodies with properties close to human intravenous immunoglobulin (IVIg)
28. Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins
29. In-vitro inhibition of antiplatelet autoantibodies by intravenous immunoglobulins and Rh immunoglobulins
30. Antiidiotype antibody against platelet anti-GPIIIa contributes to the regulation of thrombocytopenia in HIV-1-ITP patients
31. Intravenous treatment reduces atherosclerosis in apo E knockout mice
32. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice
33. Alloimmunization to platelet antigens
34. Effect of antiidiotypic antibodies to HLA on graft survival in renal-allograft recipients
35. Selectivity of recognition of Variable (V) regions of autoantibodies by intravenous immunoglobulin (IVIg)
36. Antiidiotypic suppression of autoantibodies with normal polyspecific immunoglobulins
37. Human immunoglobulin presss for intravenous use prevent experimental autoimmune uveoretinitis
38. Anti-inflammatory activity of, IVIG mediated through the inhibitory Fc receptor
39. Intravenous immunoglobulins for therapeutic use contain antiidiotypes against xenophile antibodies and prolong discordant graft survival
40. Intravenous immunoglobulin treatment of neurological autoimmune diseases
41. Normal polyclonal immunoglobulins ('IVIg') inhibit microglial phagocytosis in vitro
42. Interaction of heparin with platelets, including heparin-induced thrombocytopenia
43. High-dose intravenous gamma-globulins for heparin-induced thrombocytopenia: A prompt response
44. High dose intravenous IgG reduces platelet associated immunoglobulins and complement in idiopathic thrombocytopenic purpura