Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat

Experimental Animals

Volumn 50, Issue 2, 2001, Pages 115-123

  Yamada, Takahisa ^a,b   Miyake, Takeshi ^a   Sugiura, Kenkichi ^a   Narita, Akira ^a   Wei, Kaichun ^b   Wei, Suwen ^b   Moralejo, Daniel H ^b   Ogino, Tomoe ^b   Gaillard, Claude ^a,c   Sasaki, Yoshiyuki ^a   Matsumoto, Kozo ^b  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Epistasis; Genetic dissection; NIDDM; OLETF rat

Indexed keywords

ANIMALIA;

ANIMAL; ARTICLE; CHROMOSOME MAP; DIABETES MELLITUS; FISCHER 344 RAT; GENETIC EPISTASIS; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HOMOZYGOTE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; RAT;

ANIMALS; BLOOD GLUCOSE; CHROMOSOME MAPPING; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; EPISTASIS, GENETIC; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; OBESITY; RATS; RATS, INBRED F344; RATS, INBRED OLETF;

EID: 18044403348     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.50.115     Document Type: Article

References (34)

1. Bruning, J.C., Winnay, J., Bonner-Weir, S., Taylor, S.I., Accili, D., and Kahn, C.R. 1997. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88: 561-572.
2. Ciaraldi, T.P., Abrams, L., Nikoulina, S., Mudaliar, S., and Henry, R.R. 1995. Glucose transport in cultured human skeletal muscle cells. Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects. J. Clin. Invest. 96: 2820-2827.
3. Cox, N.J., Frigge, M., Nicolae, D.L., Concannon, P., Hanis, C.L., Bell, G.I., and Kong, A. 1999. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat. Genet. 21: 213-215.
4. De Sanctis, G.T., Merchant, M., Beier, D.R., Dredge, R.D., Grobholz, J.K., Martin, T.R., Lander, E.S., and Drazen, J.M. 1995. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat. Genet. 11: 150-154.
5. Fijneman, R.J.A., de Vries, S.S., Jansen, R.C., and Demant, P. 1996. Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse. Nat. Genet. 14: 465-467.
6. Frankel, W.N. and Schork, N.J. 1996. Who's afraid of epistasis? Nat. Genet. 14: 371-373.
7. Frankel, W.N., Valenzuela, A., Lutz, C.M., Johnson, E.W., Dietrich, W.F., and Coffin, J.M. 1995. New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm. Genome 6: 830-838.
8. Froguel, P., Zouali, H., Vionnet, N., Velho, G., Vaxillaire, M., Sun, F., Lesage, S., Stoffel, M., Takeda, J., Passa, P., Permutt, M.A., Beckmann, J.S., Bell, G.I., and Cohen, D. 1993. Familial hyperglycemia due to mutations in glucokinase: Definition of a subtype of diabetes mellitus. New Engl. J. Med. 328: 697-702.
9. Horikawa, Y., Iwakaki, N., Hara, M., Furuta, H., Hinokio, Y., Cockburn, B.N., Lindner, T., Yamagata, K., Ogata, M., Tomonaga, O., Kuroki, H., Kasahara, T., Iwamoto, Y., and Bell, G.I. 1997. Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with MODY. Nat. Genet. 17: 384-385.
10. Jansen, R.C. 1993. Interval mapping of multiple quantitative trait loci. Genetics 135: 205-211.
11. Kawano, K., Hirashima, T., Mori, S., Kurosumi, M., and Saitoh, Y. 1991. A new rat strain with non-insulin-dependent diabetes mellitus, "OLETF". Rat News Lett. 25: 24-26.
12. Kawano, K., Hirashima, T., Mori, U., Saitoh, Y., Kurosumi, M., and Natori, T. 1992. Spontaneous long-term hyperglycemic rat with diabetic complications, Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41: 1422-1428.
13. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R., and Berns, A. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19: 4293.
14. Lander, E.S. and Schork, N.J. 1994. Genetic dissection of complex traits. Science 265: 2037-2048.
15. Lander, E.S., Green, P., Abrahamson, J., Barlow, A., Daley, M., Lincoln, S., and Newburg, L. 1987. MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 174-181.
16. Letts, V.A., Schork, N.J., Copp, A.J., Bernfield, M., and Frankel, W.N. 1995. A curly-tail modifier locus, mct1, on mouse chromosome 17. Genomics 29: 719-724.
17. Lincoln, S.E. and Lander, E.S. 1992. Systematic detection of errors in genetic linkage data. Genomics 14: 604-610.
18. Lincoln, S.E., Daly, M., and Lander, E.S. 1992. Mapping genes controlling quantitative traits with MAPMAKER/ QTL 1.1 Whitehead Institute Technical Report, 2nd ed., Whitehead Institute for Biomedical Research, Cambridge.
19. Moralejo, D.H., Wei, S., Wei, K., Weksler-Zangen, S., Koike G., Jacob, H.J., Hirashima, T., Kawano, K., Sugiura, K., Sasaki, Y., Ogino, T., Yamada, T., and Matsumoto K. 1998. Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long-Evans Tokushima Fatty rat. Proc. Assoc. Am. Physicians 110: 545-558.
20. Mori, N., van Wezel, T., van der Valk, M., Yamate, J., Sakuma, S., Okumoto, M., and Demant, P. 1998. Genetics of susceptibility to radiation-induced apoptosis in colon: Two loci on chromosomes 9 and 16. Mamm. Genome 9: 377-380.
21. Ogino, T., Moralejo, D.H., Zhu, M., Toide, K., Wei, S., Wei, K., Yamada, T., Mizuno, A., Matsumoto, K., and Shima, K. 1999. Identification of possible quantitative trait loci responsible for hyperglycemia after 70% pancreatectomy using a spontaneously diabetogenic rat. Genet. Res. 73: 29-36.
22. Okauchi, N., Mizuno, A., Zhu, M., Ishida, K., Sato, T., Noma, Y., and Shima, K. 1995. Effects of obesity and inheritance on the development of non-insulin-dependent diabetes mellitus in Otsuka-Long-Evans-Tokushima Fatty rats. Diabetes Res. Clin. Pract. 29: 1-10.
23. Rapp, J.P., Dene, H., and Deng, A.Y. 1994. Seven renin alleles in rats and their effects on blood pressure. J. Hypertens. 12: 349-355.
24. Rieseberg, L.H., Sinervo, B., Randal-Linder, C., Ungerer, M.C., and Arias, D.M. 1996. Role of gene interactions in hybrid speciation: evidence from ancient and experimental hybrids. Science 272: 741-745.
25. Sacks, D.B. and McDonald, J.M. 1996. The pathogenesis of type II diabetes mellitus. A polygenic disease. Am. J. Clin. Pathol. 105: 149-156.
26. Schork, N.J. 1997. Genetically complex cardiovascular traits. Origins, problems, and potential solutions. Hypertension 29: 145-149.
27. Sugiura, K., Miyake, T., Taniguchi, Y., Yamada, T., Moralejo, D.H., Wei, S., Wei, K., Sasaki, Y., and Matsumoto, K. 1999. Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima Fatty rat by MQM-mapping method. Mamm. Genome 10: 1126-1131.
28. van Wezel, T., Stassen, A.P.M., Moen, C.J.A., Hart, A.A.H., van der Valk, M.A., and Demant, P. 1996. Interaction and single gene effects in colon tumor susceptibility in mice. Nat. Genet. 14: 468-470.
29. Wei, S., Wei, K., Moralejo, D.H., Yamada, T., Izumi, K., and Matsumoto, K. 1998. An integrated genetic map of the rat with 562 markers from different sources. Mamm. Genome 9: 1002-1007.
30. Wei, S., Wei, K., Moralejo, D.H., Ogino, T., Koike, G., Jacob, H.J., Sugiura, K., Sasaki, Y., Yamada, T., and Matsumoto, K. 1999. Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima Fatty rat. Mamm. Genome 10: 249-258.
31. Wright, S. 1931. Evolution in mendelian populations. Genetics 16: 97-159.
32. Wright, S. 1978. The relation of livestock breeding to theories of evolution. J. Anim. Sci. 46: 1192-1200.
33. Yamagata, K., Furuta, H., Oda, N., Kaisaki, P.J., Menzel, S., Cox, N.J., Fajans, S.S., Signorini, S., Stoffel, M., and Bell, G.I. 1996. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1). Nature 384: 458-460.
34. Yamagata, K., Oda, N., Kaisaki, P.J., Menzel, S., Furuta, H., Vaxillaire, M., Southam, L., Cox, R.O., Lathrop, M., Boriraj, V.V., Chen, X., Cox, N.J., Oda, Y., Yano, H., Le Beau, M.M., Yamada, S., Nishigori, H., Takeda, J., Fajans, S., Hattersley, A.T., Iwasaki, N., Hansen, T., Pedersen, O., Polonsky, K.S., Turner, R.C., Velho, G., Chevre, J.-C., Froguel, P., and Bell, G.I. 1996. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature 384: 455-458.