Aging and cardiac responses to epinephrine in humans: Role of neuronal uptake

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 5 57-5, 2005, Pages

  Leenen, Frans H H ^a   Coletta, Elizabeth ^a   Fourney, Anne ^a   White, Roselyn ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

receptors; Age; Baroreflex; Desipramine; Trimetaphan

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DESIPRAMINE; ISOPRENALINE; TRIMETAPHAN;

ADULT; AGE; AGED; AGING; ARTICLE; FEMALE; GANGLION BLOCK; HEART EJECTION FRACTION; HEART INDEX; HEART RATE; HEART STROKE VOLUME; HUMAN; HUMAN EXPERIMENT; MALE; NERVE CELL; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE;

ADRENERGIC BETA-AGONISTS; ADRENERGIC UPTAKE INHIBITORS; ADULT; AGED; AGING; BAROREFLEX; BLOOD PRESSURE; DESIPRAMINE; DRUG SYNERGISM; EPINEPHRINE; FEMALE; GANGLIONIC BLOCKERS; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; NEURONS; TRIMETHAPHAN;

EID: 18044381562     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00793.2004     Document Type: Article

References (27)

1. Borton M and Docherty JR. The effects of ageing on neuronal uptake of noradrenaline in the rat. Naunyn Schmiedebergs Arch Pharmacol 340: 139-143, 1989.
2. Buchholz J and Duckles SP. Effect of age on prejunctional modulation of norepinephrine release. J Pharmacol Exp Ther 252: 159-164, 1990.
3. Devereux RB and Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 55: 613-618, 1977.
4. Eisenhofer G, Friberg P, Goldstein DS, and Esler M. Differential actions of desipramine on sympathoadrenal release of noradrenaline and adrenaline. Br J Clin Pharmacol 40: 263-265, 1995.
5. Esler M, Jennings G, Lambert G, Meredith I, Horne M, and Eisenhofer G. Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions. Physiol Rev 70: 963-985, 1990.
6. Esler MD, Wallin G, Dorward PK, Eisenhofer G, Westerman R, Meredith I, Lambert G, Cox HS, and Jennings G. Effects of desipramine on sympathetic nerve firing and norepinephrine spillover to plasma in humans. Am J Physiol Regul Integr Comp Physiol 260: R817-R8123, 1991.
7. Esler M, Kaye D, Thompson J, Jennings G, Cox H, Turner A, Lambert G, and Seals D. Effects of aging on epinephrine secretion and regional release of epinephrine from the human heart. J Clin Endorcinol Metab 80: 435-442, 1995.
8. Esler MD, Turner AG, Kaye DM, Thompson JM, Kingwell BA, Morris M, Lambert GW, Jennings GL, Cox HS, and Seals DR. Aging effects on human sympathetic neuronal function. Am J Physiol Regul Integr Comp Physiol 268: R278-R285, 1995.
9. Floras JS, Sole MJ, and Morris BL. Desipramine blocks augmented neurogenic vasoconstrictor responses to epinephrine. Hypertension 15: 132-139, 1990.
10. Gilbert EM, Eiswirth CC, Mealey PC, Larrabee P, Herrick CM, and Bristow MR. β-Adrenergic supersensitivity of the transplanted human heart is presynaptic in origin. Circulation 79: 344-349, 1989.
11. Goldberg LI, Bloodwell RD, Braunwald E, and Morrow AG. The direct effects of norepinephrine, epinephrine, and methoxamine on myocardial contractile force in man. Circulation 22: 1125-1132, 1960.
12. Goldstein DS, Brush JE Jr, Eisenhofer G, Stull R, and Esler M. In vivo measurement of neuronal uptake of norepinephrine in the human heart. Circulation 78: 41-48, 1988.
13. Gribbin B, Pickering TG, Sleight P, and Peto R. Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res 29: 424-431, 1971.
14. Harris WS, Schoenfeld CD, Brooks RH, and Weissler AM. Effect of beta adrenergic blockade on the hemodynamic responses to epinephrine in man. Am J Cardiol 17: 484-492, 1966.
15. Klein CE, Nies A, and Gerber J. The effect of age on the β-adrenergic lipolytic response in healthy humans. Clin Pharmacol Ther 56: 210-216, 1994.
16. Leenen FHH, Chan YK, Smith DL, and Reeves RA. Epinephrine and left ventricular function in humans: effects of β-1 vs. nonselective β-blockade. Clin Pharmacol Ther 43: 519-528, 1988.
17. 1- versus nonselective β-blockade. Clin Pharmacol Ther 64: 522-535, 1998.
18. O'Malley K, Docherty JR, and Kelly JG. Adrenoceptor status and cardiovascular function in ageing. J Hypertens 6, Suppl 1: S59-S62, 1988.
19. Persson B, Andersson OK, Hjemdahl P, Wysocki M, Agerwall S, and Wallin G. Adrenaline infusion in man increases muscle sympathetic nerve activity and noradrenaline overflow to plasma. J Hypertens 7: 747-756, 1989.
20. Poldermans D, Boersma E, Fioretti PM, van Urk H, Boomsma F, and Man in't Veld AJ. Cardiac chronotropic responsiveness to beta-adrenoceptor stimulation is not reduced in the elderly. J Am Coll Cardiol 25: 995-999, 1995.
21. Sahn DJ, DeMaria A, Kisslo J, and Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 58: 1072-1083, 1978.
22. Sumner DJ, Elliott HL, Vincent J, and Reid JL. A pragmatic approach to the pressor dose-response as an index of vascular reactivity and adrenoceptor function in man. Br J Clin Pharmacol 23: 505-510, 1987.
23. Von Scheldt W, Bohm M, Schneider B, Reichart B, Erdmann E, and Autenrieth G. Isolated presynaptic inotropic beta-adrenergic supersensitivity of the transplanted denervated human heart in vivo. Circulation 85: 1056-1063, 1992.
24. White M, Fourney A, and Leenen FHH. Age, hypertension, and cardiac responses to beta-agonist in humans. Clin Pharmacol Ther 63: 663-671, 1998.
25. White M and Leenen FHH. Aging and cardiovascular responsiveness to beta-agonist in humans: role of changes in beta-receptor responses versus baroreflex activity. Clin Pharmacol Ther 56: 543-553, 1994.
26. White M and Leenen FHH. Effects of age on cardiovascular responses to adrenaline in man. Br J Clin Pharmacol 43: 407-414, 1997.
27. White M, Roden R, Minobe W, Khan MF, Larrabee P, Wollmering M, Port JD, Anderson F, Campbell D, Feldman AM, and Bristow MR. Age-related changes in beta-adrenergic neuroeffector systems in the human heart. Circulation 90: 1225-1238, 1994.