Age, hypertension, and cardiac responses to β-agonist in humans

Clinical Pharmacology and Therapeutics

Volumn 63, Issue 6, 1998, Pages 663-671

  White, Michel ^c   Fourney, Anne ^c   Leenen, Frans H H ^a,b  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b HEART AND STROKE FOUNDATION OF CANADA   (Canada)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ISOPRENALINE; TRIMETAPHAN;

ADULT; AGE; AGED; ARTICLE; CATECHOLAMINE BLOOD LEVEL; CHRONOTROPISM; CLINICAL ARTICLE; DIASTOLIC BLOOD PRESSURE; ECHOCARDIOGRAPHY; FEMALE; GANGLION BLOCK; HEART INDEX; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART RATE; HEART STROKE VOLUME; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE;

ADRENERGIC BETA-AGONISTS; ADULT; AGED; AGING; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CATECHOLAMINES; DRUG THERAPY, COMBINATION; FEMALE; HEART RATE; HUMANS; HYPERTENSION; INFUSIONS, INTRAVENOUS; ISOPROTERENOL; MALE; MIDDLE AGED; TREATMENT OUTCOME; TRIMETHAPHAN; VENTRICULAR FUNCTION, LEFT;

EID: 0031819539     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(98)90090-X     Document Type: Article

References (20)

1. Feldman RD, Limbird LE, Nadeau J, Robertson D, Wood AJJ. Leukocyte β-receptor alterations in hypertensive subjects. J Clin Invest 1984;73:648-53.
2. White M, Roden R, Minobe W, Khan F, Larrabee P, Wollmering M, et al. Age-related changes in β-adrenergic neuroeffector systems in the human heart. Circulation 1994;90:1225-38.
3. Arnold JMO, McDevitt DG. Contribution of the vagus to the hemodynamic responses following intravenous boluses of isoprenaline. Br J Clin Pharmacol 1983; 15:423-9.
4. Arnold JMO, MCDevitt DG. Vagal activity is increased during intravenous isoprenaline infusion in man. Br J Clin Pharmacol 1984;18:311-6.
5. Levine MAH, Leenen FHH. Role of beta-1 adrenoreceptors and vagal tone in cardiac inotropic and chronotropic responses to a beta-2 agonist in man. Circulation 1989;79:107-15.
6. White M, Leenen FHH. Aging and cardiovascular responsiveness to β-agonist in humans: role of changes in β-receptor responses versus baroreflex activity. Clin Pharmacol Ther 1994;56:543-53.
7. Stratton JR, Cerqueira MD, Schwartz RS, Levy WC, Veith RC, Kahn SE, et al. Differences in cardiovascular responses to isoproterenol in relation to age and exercise training in healthy men. Circulation 1992;86:504-12.
8. Poldermans D, Boersma E, Fioretti PM, van Urk H, Boomsma F, Man In't Veld A. Cardiac chronotropic responsiveness to beta-adrenoceptor stimulation is not reduced in the elderly. J Am Coll Cardiol 1995;25:995-9.
9. Alicandri C, Boni E, Fariello R, Zaninelli A, Minotti F, Cantalamessa A, et al. Parasympathetic control of heart rate and age in essential hypertensive patients. J Hypertens 1987; 5(suppl 5):S345-7.
10. Gribbin B, Pickering TG, Sleight P, Peto R. Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res 1971;29:424-9.
11. Leenen FHH, Boer P, Dorhout Mees EJ. Peripheral β-adrenoceptor responsiveness in young normotensive and hypertensive subjects. Clin Exp Hypertens 1981; 3:539-53.
12. Jennings G, Bobik A, Elser M, Korner P. Contribution of cardiovascular reflexes to differences in β-adrenoceptor-mediated responses in essential hypertension. Clin Sci 1981;61:177s-80s.
13. Bertel O, Buhler FR, Kiowski W, Lutold BE. Decreased beta-adrenoreceptor responsiveness as related to age, blood pressure, and plasma catecholamines in patients with essential hypertension. Hypertension 1980;2:130-8.
14. London GM, Safar ME, Weiss YA, Milliez PL. Isoproterenol sensitivity and total body clearance of propranolol in hypertensive patients. J Clin Pharmacol 1976; 16:174-83.
15. Dimsdale J, Ziegler M. The effect of hypertension, sodium, and race on isoproterenol sensitivity. Clin Exp Hypertens 1988;A10:747-56.
16. Kawamoto A, Shimada K, Matsubayashi K, Chikamori T, Kuzme O, Ogura H, et al. Cardiovascular regulatory functions in elderly patients with hypertension. Hypertension 1989;13:401-7.
17. Sole MJ, Hussain MN. A simple and specific radioenzymatic assay for the simultaneous measurement of picogram quantities of noradrenaline, adrenaline and dopamine in plasma and tissues. Biochem Med 1977;18:301-7.
18. Buhler FR, Kiowski W, van Brummelen P, Amann FW, Bertel O, Landmann R, et al. Plasma catecholamines and cardiac, renal and peripheral vascular adrenoceptor-mediated responses in different age groups of normal and hypertensive subjects. Clin Exp Hypertens 1980;2:409-26.
19. Leenen FHH, Reeves RA. The beta-receptor mediated increase in venous return in humans. Can J Physiol Pharmacol 1987;65:1658-65.
20. Goldstein DS, Zimlichman R, Stull R, Keiser HR. Plasma catecholamine and hemodynamic responses during isoproterenol infusions in humans. Clin Pharmacol Ther 1986;40:233-8.