Covariate detection in population pharmacokinetics using partially linear mixed effects models

Pharmaceutical Research

Volumn 22, Issue 4, 2005, Pages 541-549

  Bonate, Peter L ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

Linear mixed effects model; NONMEM; Regression splines; Semiparametric mixed effects models; Splines

Indexed keywords

GLYCOPEPTIDE; TEICOPLANIN;

ANALYSIS OF VARIANCE; ARTICLE; CALCULATION; CONCENTRATION (PARAMETERS); CONFIDENCE INTERVAL; CORRELATION ANALYSIS; DATA ANALYSIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; SAMPLE; SIMULATION; STATISTICAL MODEL;

COMPUTER SIMULATION; HUMANS; LIKELIHOOD FUNCTIONS; LINEAR MODELS; MODELS, BIOLOGICAL; PHARMACOKINETICS;

EID: 18044381115     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-005-2492-z     Document Type: Article

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