Role of HdeA in acid resistance and virulence in Brucella abortus 2308

Veterinary Microbiology

Volumn 107, Issue 3-4, 2005, Pages 307-312

  Valderas, Michelle Wright ^a,d   Alcantara, Rosemarie B ^a   Baumgartner, John E ^a   Bellaire, Bryan H ^b   Robertson, Gregory T ^c,e   Ng, Wai Leung ^c,f   Richardson, John M ^c   Winkler, Malcolm E ^c,f   Roop II, R Martin ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d OKLAHOMA STATE UNIVERSITY   (United States)

^e Cumbre Inc   (United States)

^f INDIANA UNIVERSITY   (United States)

Author keywords

Acid resistance; Brucella; Brucellosis; Hfq; Macrophages

Indexed keywords

CARBENICILLIN; CHAPERONE; CHLORAMPHENICOL; GENE PRODUCT; HOST FACTOR 1; PROTEIN HDEA; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; BRUCELLA ABORTUS; CONTROLLED STUDY; GENE SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; SEQUENCE HOMOLOGY;

BACTERIA (MICROORGANISMS); BRUCELLA; BRUCELLA MELITENSIS BIOVAR ABORTUS;

EID: 18044375774     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2005.01.018     Document Type: Article

References (22)

1. G.G. Alton, L.M. Jones, R.D. Angus, and J.M. Verger Techniques for the Brucellosis Laboratory 1988 Institut National de la Recherche Agronomique Paris, France
2. F.M. Ausubel R. Brent R.E. Kingston D.D. Moore J.G. Seidman J.A. Smith D. Struhl Current Protocols in Molecular Biology 2000 John Wiley & Sons New York, NY
3. M.L. Boschiroli, S. Ouahrani-Bettache, V. Foulongne, S. Michaux-Charachon, G. Bourg, A. Allardet-Servent, C. Cazielle, J.-P. Lavigne, J.P. Liautard, M. Ramuz, and D. O'Callaghan Type IV secretion and Brucella virulence Vet. Microbiol. 90 2002 341 348
4. L. Brown, and T. Elliott Efficient translation of the RpoS sigma factor in Salmonella typhimurium requires host factor I, an RNA-binding protein encoded by the hfq gene J. Bacteriol. 178 1996 3763 3770
5. J. Celli, C. de Chastellier, D.M. Franchini, J. Pizarro-Cerda, E. Moreno, and J.P. Gorvel Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum J. Exp. Med. 198 2003 545 556
6. V.G. Del Vecchio, V. Kapatral, R.R. Redkar, G. Patra, C. Mujer, T. Los, N. Ivanova, I. Anderson, A. Bhattacharyya, A. Lykidis, G. Reznik, L. Jablonski, N. Larsen, M. D'Souza, A. Bernal, M. Mazur, E. Goltsman, E. Selkov, P.H. Elzer, S.D. Hagius, D. O'Callaghan, J.-J. Letesson, R. Haselkorn, N. Kyrpides, and R. Overbeek The genome sequence of the facultative intracellular pathogen Brucella melitensis Proc. Natl. Acad. Sci. U.S.A. 99 2002 443 448
7. P.H. Elzer, R.W. Phillips, M.E. Kovach, K.M. Peterson, and R.M. Roop II Characterization and genetic complementation of a Brucella abortus high-temperature requirement A (htrA) deletion mutant Infect. Immun. 62 1994 4135 4139
8. P.H. Elzer, R.W. Phillips, G.T. Robertson, and R.M. Roop II The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes Infect. Immun. 64 1996 4838 4841
9. K.S. Gajiwala, and S.K. Burley HdeA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria J. Mol. Biol. 295 2000 605 612
10. Gee, J.M., Valderas, M.W., Kovach, M.E., Grippe, V.K., Robertson, G.T., Ng, W.-L., Richardson, J.M., Winkler, M.E., Roop, R.M. II, 2005. The Brucella abortus Cu/Zn superoxide dismutase (SodC) is required for optimal resistance to oxidative killing by murine macrophages and wild type virulence in experimentally infected mice. Infect. Immun. 73, in press.
11. P. Gerhardt, and J.B. Wilson The nutrition of brucellae: growth in simple chemically defined media J. Bacteriol. 56 1948 17 24
12. s subunit of RNA polymerase in Escherichia coli J. Bacteriol. 179 1997 297 300
13. H. Nielsen, J. Engelbrecht, S. Brunak, and G. von Heijne Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites Protein Eng. 10 1997 1 6
14. F. Porte, J.P. Liautard, and S. Köhler Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages Infect. Immun. 67 1999 4041 4047
15. G.T. Robertson, and R.M. Roop II The Brucella abortus host factor I (HF-I) protein contributes to stress resistance during stationary phase and is a major determinant of virulence in mice Mol. Microbiol. 34 1999 690 700
16. G.T. Robertson, A. Reisenauer, R. Wright, R.B. Jensen, A. Jensen, L. Shapiro, and R.M. Roop II The Brucella abortus CcrM DNA methyltransferase is essential for viability, and its overexpression attenuates intracellular replication in murine macrophages J. Bacteriol. 182 2000 3482 3489
17. R.M. Roop II, J.M. Gee, G.T. Robertson, J.M. Richardson, W.-L. Ng, and M.E. Winkler Brucella stationary phase gene expression and virulence Annu. Rev. Microbiol. 57 2003 57 76
18. R.M. Roop II, B.H. Bellaire, M.W. Valderas, and J.A. Cardelli Adaptation of the brucellae to their intracellular niche Mol. Microbiol. 52 2004 621 630
19. B. Rosner Fundamentals of Biostatistics fifth ed. 2000 Duxbury Pacific Grove, CA
20. H.C. Tsui, H.E. Leung, and M.E. Winkler Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia coli K-12 Mol. Microbiol. 13 1994 35 49
21. P. Valentin-Hansen, M. Eriksen, and C. Udesen The bacterial Sm-like protein Hfq: a key player in RNA transactions Mol. Microbiol. 51 2004 1525 1533
22. s- dependent genes associated with the stationary-phase acid-resistance phenotype of Shigella flexneri Mol. Microbiol. 21 1996 925 940