Gender differences in a fenfluramine-activated FDG PET study of borderline personality disorder

Psychiatry Research - Neuroimaging

Volumn 138, Issue 3, 2005, Pages 183-195

  Soloff, Paul H ^a,b   Meltzer, Carolyn Cidis ^a   Becker, Carl ^a   Greer, Phil J ^a   Constantine, Doreen ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Aggression; d,l fenfluramine; Impulsivity; Positron emission tomography; Prefrontal cortex; Serotonin

Indexed keywords

FENFLURAMINE; FLUORODEOXYGLUCOSE F 18; PLACEBO;

ADULT; AGGRESSION; ARTICLE; BORDERLINE STATE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG UPTAKE; FEMALE; FRONTAL CORTEX; GLUCOSE UTILIZATION; HUMAN; IMPULSIVENESS; MALE; NEUROIMAGING; OCCIPITAL CORTEX; ORBITAL CORTEX; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE BLIND PROCEDURE; TEMPORAL LOBE;

EID: 18044370692     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2005.02.008     Document Type: Article

References (62)

1. M. Arató, E. Frecska, K. Tekes, and D.J. MacCrimmon Serotonergic interhemispheric asymmetry gender differences in the orbital cortex Acta Psychiatrica Scandinavica 84 1991 110 111
2. 3H-imipramine binding in the frontal cortex of suicides Psychiatry Research 30 1989 125 135
3. M. Åsberg, D. Schalling, L. Träskman-Benz, and A. Wagner Psychobiology of suicide, impulsivity, and related phenomena H.Y. Meltzer Psychopharmacology: The Third Generation of Progress 1987 Raven Press New York
4. E. Baca-Garcia, C. Vaquero, C. Diaz-Sastre, J. Saiz-Ruiz, J. Fernandez-Piqueras, and J. de Leon A gender-specific association between the serotonin transporter gene and suicide attempts Neuropsychopharmacology 26 2002 692 695
5. 123I-5-I-R91150, a new single photon emission tomography ligand for 5-HT2A receptors: influence of age and gender in healthy subjects European Journal of Nuclear Medicine 25 12 1998 1617 1622
6. E.L. Barratt Factor analysis of some psychometric measures of impulsiveness and anxiety Psychological Reports 16 1965 547 554
7. A.T. Beck, R. Beck, and M. Kovacs Classification of suicidal behavior: I. Quantifying intent and medical lethality American Journal of Psychiatry 132 1975 285 287
8. F. Biver, F. Lotstra, M. Monclus, D. Wikler, P. Damhut, J. Mendlewicz, and S. Goldman Sex difference in 5HT2 receptor in the living human brain Neuroscience Letters 204 1-2 1996 25 28
9. J.D. Bremner, M. Vythilingam, E. Vermetten, A. Nazeer, J. Adil, S. Khan, L.H. Staib, and D.S. Charney Reduced volume of orbitofrontal cortex in major depression Biological Psychiatry 51 2002 273 279
10. A.L. Brody, S. Saxena, M.A. Mandelkern, L.A. Fairbanks, M.L. Ho, and L.R. Baxter Jr. Brain metabolic changes associated with symptom factor improvement in major depressive disorder Biological Psychiatry 50 2001 171 178
11. G.L. Brown, M.H. Ebert, P.F. Goyer, D.C. Jimerson, W.J. Klein, W.E. Bunney, and F.K. Goodwin Aggression, suicide, and serotonin: relationships to CSF amine metabolites American Journal of Psychiatry 139 1982 741 746
12. R.J. Cadoret, D. Langbehn, K. Caspers, E.P. Troughton, R. Yucuis, H.K. Sandhu, and R. Philibert Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit and conduct disorder in an adoptee population Comprehensive Psychiatry 44 2 2003 88 101
13. A.J. Cleare, and A.J. Bond Does central serotonergic function correlate inversely with aggression? A study using d-fenfluramine in healthy subjects Psychiatry Research 69 1997 89 95
14. H. Damasio, T. Grabowski, R. Frank, A.M. Galaburda, and A.R. Damasio The return of Phineas Gage: clues about the brain from the skull of a famous patient Science 264 1994 1102 1105
15. J.M. De La Fuente, S. Goldman, E. Stanus, C. Vizuete, I. Morlan, J. Bobes, and J. Mendlewicz Brain glucose metabolism in borderline personality disorder Journal of Psychiatric Research 31 1997 531 541
16. W.C. Drevets Neuroimaging studies of mood disorders Biological Psychiatry 48 2000 813 829
17. L. Du, D. Bakish, and P.D. Hrdina Gender differences in association between serotonin transporter gene polymorphism and personality traits Psychiatric Genetics 10 2000 159 164
18. K.J. Friston, A.P. Holmes, K.J. Worsley, J.B. Poline, C.D. Frith, and R.S.J. Frackowiak Statistical parametric maps in functional imaging: a general approach Human Brain Mapping 2 1995 189 210
19. P.F. Goyer, P.J. Andreason, W.E. Semple, A.H. Clayton, A.C. King, B.A. Compton-Toth, S.C. Schulz, and R.M. Cohen Positron-emission tomography and personality disorders Neuropsychopharmacology 10 1994 21 28
20. J.G. Gunderson, J.E. Kolb, and V. Austin The Diagnostic Interview for Borderlines American Journal of Psychiatry 138 1981 896 903
21. W. Guy ECDEU Assessment Manual of Psychopharmacology-Revised (DHEW Publ. No. ADM 76-338) Superintendent of Documents 1976 U.S. Government Printing Office Washington, DC
22. U. Halbreich, N. Rojansky, K.J. Zander, and A. Barkai Influence of age, sex, and diurnal variability on imipramine receptor binding and serotonin uptake in platelets of normal subjects Journal of Psychiatric Research 25 1991 7 18
23. S. Herpertz, H. Sass, and A. Favazza Impulsivity in self-mutilative behavior: psychometric and biologic findings Journal of Psychiatric Research 31 1997 451 465
24. E. Hollander, D.J. Stein, C.M. DeCaria, L. Cohen, J.B. Saoud, A.E. Skodol, D. Kellman, L. Rosnick, and J.M. Oldham Serotonergic sensitivity in borderline personality disorder: preliminary findings American Journal of Psychiatry 151 1994 277 280
25. F.D. Juengling, C. Schmahl, B. Hesslinger, D. Ebert, J.D. Bremner, J. Gostomzyk, M. Bohus, and K. Lieb Positron emission tomography in female patients with borderline personality disorder Journal of Psychiatric Research 37 2003 109 115
26. S. Kapur, J. Meyer, A.A. Wilson, S. Houle, and G.M. Brown Modulation of cortical neuronal activity by a serotonergic agent: a PET study in humans Brain Research 646 1994 292 294
27. 3H-paroxetine to blood platelets in healthy volunteers: indications for a gender difference Biological Psychiatry 28 1990 509 517
28. 3H-imipramine binding in human platelets Archives of Pharmacology 313 1980 189 194
29. A.W. Loranger, V.L. Susman, J.M. Oldham, and L.M. Russakoff The Personality Disorder Examination: a preliminary report Journal of Personality Disorders 1 1987 1 3
30. P. Malloy, A. Bihrle, and J. Duffy The orbitomedial frontal syndrome Archives of Clinical Neuropsychology 8 1993 185 201
31. J.J. Mann, K.M. Malone, D.J. Diehl, J. Perel, T.E. Nichols, and M.A. Mintun Positron emission tomographic imaging of serotonin activation effects on prefrontal cortex in healthy volunteers Journal of Cerebral Blood Flow and Metabolism 16 1996 418 426
32. S.B. Manuck, J.D. Flory, J.M. McCaffery, K.A. Matthews, J.J. Mann, and M.F. Muldoon Aggression, impulsivity and central nervous system serotonergic responsivity in a nonpatient sample Neuropsychopharmacology 19 1998 287 299
33. S.B. Manuck, J.D. Flory, R.E. Ferrell, K.M. Dent, J.J. Mann, and M.F. Muldoon Aggression and anger related traits associated with a polymorphism of the tryptophan hydroxylase gene Biological Psychiatry 45 1999 603 614
34. 3H]-paroxetine binding to human platelets Journal of Affective Disorders 50 1998 11 15
35. J. Martial, J. Paris, M. Leyton, H. Zweig-Frank, G. Schwartz, E. Teboul, J. Thavundayil, S. Larue, N.M.K. Kin, and N.P. Nair Neuroendocrine study of serotonin function in female borderline personality disorder patients: a pilot study Biological Psychiatry 42 1997 737 739
36. H.S. Mayberg, M. Liotti, S.K. Brannan, S. McGinnis, R.K. Mahurin, P.A. Jerabek, J.A. Silva, J.L. Tekell, C.C. Martin, J.L. Lancaster, and P.T. Fox Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness American Journal of Psychiatry 156 1999 675 682
37. P.A. McBride, H. Tierney, M. DeMeo, J.-S. Chen, and J.J. Mann Effects of age and gender on CNS serotonergic responsivity in normal adults Biological Psychiatry 27 1990 1143 1155
38. C.C. Meltzer, W.C. Drevets, J.C. Price, C.A. Mathis, B. Lopresti, P.J. Greer, V. Villemagne, D. Holt, N.S. Mason, P.R. Houck, C.F. Reynolds, and S.T. DeKosky Gender-specific aging effects on the serotonin 1A receptor Brain Research 895 1-2 2001 9 17
39. M.F. Muldoon, S.B. Manuck, C.L. Jansma, A.L. Moore, J. Perel, and J.J. Mann d,l-Fenfluramine challenge test: experience in non-patient sample Biological Psychiatry 39 1996 761 768
40. A.S. New, E.A. Hazlett, M.S. Buchsbaum, M. Goodman, D. Reynolds, V. Mitropoulou, L. Sprung, R.B. Shaw Jr., H. Koenigsberg, J. Platholi, J. Silverman, and L.J. Siever Blunted prefrontal cortical [F-18] fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression Archives of General Psychiatry 59 2002 621 629
41. A.S. New, R.L. Trestman, V. Mitropoulou, D. Benishay, E. Coccaro, and L.J. Siever Serotonergic function and self injurious behavior in personality disorder patients Psychiatry Research 69 1 1997 17 26
42. M.A. Oquendo, and J.J. Mann The biology of impulsivity and suicidality Psychiatric Clinics of North America 23 2000 11 25
43. M.A. Oquendo, G.P.A. Placidi, K.M. Malone, C. Campbell, J. Keilp, B. Brodsky, L.S. Kegeles, T.B. Cooper, R.V. Parsey, R.L. van Heertum, and J.J. Mann Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression Archives of General Psychiatry 60 2003 14 22
44. R.V. Parsey, M.A. Oquendo, N.R. Simpson, R.T. Ogden, R. Van Heertum, V. Arango, and J.J. Mann Effects of sex, age and aggressive traits in man on brain serotonin 5 HT1A receptor binding potential measured by PET using [C-11] WAY-100635 Brain Research 954 2 2002 173 182
45. P. Pietrini, M. Guazzelli, G. Basso, K. Jaffe, and J. Grafman Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects American Journal of Psychiatry 157 11 2000 1172 1781
46. A. Raine, M. Buchsbaum, and L. LaCasse Brain abnormalities in murderers indicated by positron emission tomography Biological Psychiatry 42 1997 495 508
47. T. Rinne, H.G.M. Westenberg, J.A. den Boer, and W. van den Brink Serotonergic blunting to meta-chlorophenylpiperazine (m-CPP) highly correlates with sustained childhood abuse in impulsive and autoaggressive female borderline patients Biological Psychiatry 47 2000 548 556
48. C.A. Sanislow, C.M. Grilo, L.C. Morey, D.S. Bender, A.E. Skodol, J.G. Gunderson, M.T. Shea, R.L. Stout, M.C. Zanarini, and T.H. McGlashan Confirmatory factor analysis of DSM-IV criteria for borderline personality disorder: findings from the collaborative longitudinal personality disorders study American Journal of Psychiatry 159 2002 284 290
49. R.G. Shulman Functional imaging studies: linking mind and basic neuroscience American Journal of Psychiatry 158 2001 11 20
50. 18F]- fluorodeoxyglucose positron emission tomography Neuropsychopharmacology 20 1999 413 423
51. H. Soderstrom, M. Tullberg, C. Wikkelso, S. Ekholm, and A. Forsman Reduced regional cerebral blood flow in non-psychotic violent offenders Psychiatry Research: Neuroimaging 98 2000 29 41
52. H. Soderstrom, L. Hultin, M. Tullberg, C. Wikkelso, S. Ekholm, and A. Forsman Reduced frontotemporal perfusion in psychopathic personality Psychiatry Research: Neuroimaging 114 2002 81 94
53. P.H. Soloff, T.M. Kelly, S.J. Strotmeyer, K.M. Malone, and J.J. Mann Impulsivity, gender and response to fenfluramine challenge in borderline personality disorder Psychiatry Research 119 2003 11 24
54. P.H. Soloff, C.C. Meltzer, C. Becker, P.J. Greer, T.M. Kelly, and D. Constantine Impulsivity and prefrontal hypometabolism in borderline personality disorder Psychiatry Research: Neuroimaging 123 2003 153 163
55. P.H. Soloff, C.C. Meltzer, P.J. Greer, D. Constantine, and T.M. Kelly A fenfluramine-activated FDG-PET study of borderline personality disorder Biological Psychiatry 47 2000 540 547
56. 3H-imipramine binding in healthy controls: age and gender effects Biological Psychiatry 40 1996 981 985
57. R.L. Spitzer, J.B.W. Williams, M. Gibbon, and M.B. First Instruction Manual for the Structured Clinical Interview for DSM-III-R (SCID). Biometrics Research 1988 New York State Psychiatric Institute New York
58. B. Stanley, A. Molcho, M. Stanley, R. Winchel, M.J. Gameroff, B. Parsons, and J.J. Mann Association of aggressive behavior with altered serotonergic function in patients who are not suicidal American Journal of Psychiatry 157 4 2000 609 614
59. D.J. Stein, E. Hollander, L. Cohen, M. Frenkel, J.B. Saoud, C. DeCaria, B. Aronowitz, A. Levin, M.R. Liebowitz, and L. Cohen Neuropsychiatric impairment in impulsive personality disorders Psychiatry Research 48 1993 257 266
60. M. Virkkunen, A. Nuutila, F.K. Goodwin, and M. Linnoila Cerebrospinal fluid metabolite in male arsonists Archives of General Psychiatry 44 1987 241 247
61. M. Virkkunen, J. DeJong, J. Bartko, F.K. Goodwin, and M. Linnoila Relationship of psychobiological variables to recidivism in violent offenders and impulsive fire-setters. A follow-up study Archives of General Psychiatry 46 1989 600 603
62. R.P. Woods, J.C. Mazziotta, and S.R. Cherry MRI-PET registration with automated algorithm Journal of Computer Assisted Tomography 17 1993 536 546