Cyclosporine reduces basolateral, but not apical, nitric oxide secretion in medullary thick ascending limb cells

Transplant International

Volumn 13, Issue SUPPL. 1, 2000, Pages

  Wu, M S ^a   Bens, M ^b   Yu, H M ^a   Vandewalle, A ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b INSERM   (France)

Author keywords

Cyclosporine; Nitric oxide; Thick ascending limb cells

Indexed keywords

CYCLOSPORIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE;

ANIMAL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CYTOLOGY; DRUG EFFECT; GENETICS; HENLE LOOP; KIDNEY MEDULLA; METABOLISM; MOUSE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIGHT JUNCTION;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CYCLOSPORINE; KIDNEY MEDULLA; LOOP OF HENLE; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIGHT JUNCTIONS;

EID: 18044363902     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2000.tb02050.x     Document Type: Article

References (16)

1. Adragna NC, Lauf PK (1998) Role of nitrite, a nitric oxide derivative, in K-Cl cotransport activation of low-potassium sheep red blood cells. J Membr Biol 166: 157-167
2. Andoh TF, Burdmann EA, Fransechini N, Houghton DC, Bennett WM (1996) Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. Kidney Int 50: 1110-1117
3. Brezis M, Heymen SN, Dinosur D (1991) Role of nitric oxide in renal medullary oxygenation. J Clin Invest 88: 390-395
4. Devarajan P, Kaskel FJ, Albeit LA, Moore LC (1989) Cyclosporine nephrotoxicity: blood volume, sodium conservation, and renal hemodynamics. Am J Phyiol 256:F71-F78
5. Haynes WG, Hand MF, Dockrell ME, Eadington DW, Lee MR, Hussein Z, Benjamin N, Webb DJ (1997) Physiological role of nitric oxide in regulation of renal function in humans. Am J Physiol 272:F364-371
6. Lahera V, Navarro-Cid J, Cachofeiro V, Garcia-Estan J, Ruilope LM (1997) Nitric oxide, the kidney, and hypertension. Am J Hypertens 10: 129-140
7. McNally PG, Feehally J (1992) Pathophysiology of cyclosporin A nephrotoxicity: experimental and clinical observations. Nephrol Dial Transplant 7: 791-804
8. Mohaupt MG, Elzie JL, Ahn KY, Clapp WL, Wilcox CS, Kone BC (1994) Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney. Kidney Int 46: 653-665
9. Mohaupt M, Schoecklmann HO, Schulze-Lohoff E, Sterzel RB (1994) Altered nitric oxide production and exogenous nitric oxide do not affect the proliferation of rat mesangial cells. J Hypertens 12: 401-408
10. Mo L, Hellmich HL, Fong P, Wood T, Embesi J, Wills NK (1999) Comparison of amphibian and human ClC-5: similarity of functional properties and inhibition by external pH. J Membr Biol 168: 253-264
11. Morrissey JJ, McCracken R, Kaneto H, Vehaskari M, Montani D, S K (1994) Localization of an inducible nitric oxide synthase mRNA in the normal kidney. Kidney Int 45: 998-1005
12. Myers BD, Ross J, Newton L, Luetscher J, Perlroth M (1984) Cyclosporine-associated chronic nephropathy. N Engl J Med 311: 699-705
13. Riccaldi D, Robic D, Bens M, Cluzeaud F, Wu MS, Bourbouze R, Vandewalle A (1995) Cultured proximal cells derived from transgenic mouse provide a model to study drug toxicity. Kidney Int 48: 722-730
14. Tojo A, Gross SS, Zhang L, Tisher CC, Schmidt HH, Wilcox CS, Madsen KM (1994) Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney. J Am Soc Nephrol 4: 1438-1447
15. Wu MS, Bens M, Cluzeaud F, Vandewalle A (1994) Role of F-actin in the activation of Na(+)-K(+)-Cl- cotransport by forskolin and vasopressin in mouse kidney cultured thick ascending limb cells. J Membr Biol 142: 323-336
16. Wu MS, Yang CW, Bens M, Yu HM, Huang JY, Wu CH, Huang CC, Vandewalle A (1998) Cyclosporin inhibits nitric oxide production in medullary ascending limb cultured cells. Nephrol Dial Transplant 13: 2814-2820