RhoA expression is not a critical determinant in hypertension evolution in salt-sensitive Dahl rats

Medical Science Monitor

Volumn 9, Issue 12, 2003, Pages

  Yoneda, Takeshi ^a   Kihara, Yasuki ^a   Takenaka, Hiroyuki ^a   Onozawa, Yoko ^a   Sarai, Nobuaki ^a   Kita, Toru ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Dahl rats; Hypertension; RhoA; Salt sensitivity

Indexed keywords

MESSENGER RNA; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA KINASE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HYPERTENSION; MALE; MUSCLE CONTRACTION; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; SALT INTAKE; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; GENE EXPRESSION; HYPERTENSION; MALE; RATS; RATS, INBRED DAHL; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; SODIUM CHLORIDE; SODIUM, DIETARY;

EID: 17944396065     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. MacMahon, S, Peto R, Cutler J et al: Blood pressure, stroke and coronary heart disease. Part I, Prolonged differences in blood pressure; prospective observational studies corrected for the regression dilution bias. Lancet, 1990; 335: 765-774
2. Klag MJ, Whelton PK, Randall BJ et al: Blood pressure and end-stage renal disease in men. N Engl J Med, 1996; 334: 13-18
3. Hansson L: The Hypertension Optimal Treatment study and the importance of lowering blood pressure. J Hypertens, 1999; 17(suppl): S9-S13
4. Freis ED: Salt, volume and the prevention of hypertension. Circulation, 1976; 56: 589-594
5. Elliott P: Observational studies of salt and blood pressure. Hypertension 1991; 17(suppl I): I-3-I-8
6. Uehata M, Ishizaki T, Satoh H et al: Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature, 1997; 389: 990-994
7. Kimura K, Ito M, Amino M et al: Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-Kinase). Science, 1996; 273: 245-248
8. Sawada N, Ito H, Ueyama K et al: Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries. Circulation, 2000; 101: 2030-2033
9. Limas C, Westrum B, Iwai J, Limas CJ: Aortic morphology in salt-dependent genetic hypertension. Am J Pathol, 1982; 107: 378-94
10. Inoko M, Kihara Y, Fujiwara H, Sasayama S: Transition from compensatory hypertrophy to dilated, failing left ventricles in Dahl salt-sensitive rats. Am J Physiol, 1994; 267: H2471-H2482
11. Iwanaga Y, Kihara Y, Inagaki K et al: Differential effects of angiotensin II versus endothelin-1 inhibitions in hypertrophic left ventricular myocardium during transition to heart failure. Circulation, 2001; 104: 606-612
12. Yoneda T, Kihara Y, Ohkusa T et al: Calcium handling and sarcoplasmic-reticular protein functions during heart-failure transition in ventricular myocardium from rats with hypertension. Life Sci, 2001; 70(2): 143-167
13. Izumi T, Kihara Y, Inagaki K et al: Re-induction of T-type calcium channels by endothelin-1 in failing hearts in vivo and adult rat ventricular myocytes in vitro. Circulation, in press.
14. van Nieuw Amerongen GP, van Delft S, Vermeer MA et al: Activation of RhoA by thrombin in endothelial hyperpermeability. Circ Res, 2000; 87: 335-340