Genotoxic effects of commonly used pesticides of South India in human lymphocytes

Pollution Research

Volumn 24, Issue 1, 2005, Pages 7-12

  Nair, R Sreekumaran ^a   Paulmurugan, R ^b   Wilsanand, V ^b,c  

^a RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

^b PMT College   (India)

^c Sree Narayana College   (India)

Author keywords

2,4 D; DNA damage; Genotoxicity; Lindane; Pesticides; Phosphamidon; Sevin; Toxicity

Indexed keywords

DNA; GENOTOXICITY; PESTICIDE; POISONING;

ASIA; EASTERN HEMISPHERE; EURASIA; INDIA; SOUTH ASIA; WORLD;

EID: 17944373470     PISSN: 02578050     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Amer, S.M., Fahmy, M.A., Donya, S.M. 1996. Cytogenetic effect of some insecticides in mouse spleen. J.Appl.Toxicol 16: 1-3.
2. Anon, 1996. Chromosome aberration OECD, guidelines for testing of chemicals, updated. Guideline 473, Genetic toxicology; In vitro Mammalian chromosome aberration test. Organisation for economic cooperation and development, Paris.
3. Anon 2000. Directorate of plant protection and quarantine Faridabad, New Delhi, India.
4. Ausech, A.G., Colus, D., Mara, I., 2000. Chromosomal aberrations analysis in a Brazilian population exposed to pesticides. Teratog Carcinog Mutagen 20: 265-272.
5. Farah, M.A., Atteq, B., Ali, M.N., Ahmad, W. 2003. Evaluation of genotoxicity of PCP and 2, 4-D by micronucleus test in freshwater fish Channa punctatus. Ecotoxicol Environ Safe 54: 25-9.
6. Flemming, L., Lisbeth, E.K., Michael, O.G., Hilkka, J., Hannu, N. 2000. Chromosome aberration in pesticide exposed green house workers. Scand J Work Environ Health 26: 436-442.
7. Kourakis, A., Mouratidou, M., Barbouti, A,, Dimikiotou, M. 1996. Cytogenetic effects of occupational esposure in the peripheral blood lymphocytes of psticide sprayers. Carcinogenesis 17: 99-101.
8. Kourakiks, K., Mopuratidou, M., Kokinos, G., Barbouti, A., Kolsis et al. 1992. Frequencies of chromosome aberrations in pesticide sprayers working in plastic green houses. Mut Res 279: 145-148.
9. Massimo, M., Milena, V., Scassellati, S.G., Rossana, P. 2000. Pesticide induced primary DNA damage in peripheral blood leukocytes of farm workers evaluated by the computerised comet assay. Biomarkers 5: 192-204.
10. Mathur, P.C. 1998. Pesticides Industry in India. Pestic Information 23: 17-29.
11. Olive, P.L., Banath, J.P., Durand, R.E. 1990. Heterogeneity in radiation induced DNA damage and repair in tumor and normal cells measured using "comet" assay. Radiat Res, 122: 86-94.
12. Pavlica, M., Papes, D., Nagy, B. 1991. 2,4-Dichlorophenoxyacetic acid causes chromatin and chromosome abonrmalities in plant cells and mutation in cultured mammalian cells. Mut Res 263-277.
13. Pool-Zobel, B.L., Guigas, C., Klein, R., Necudecker, C., Renner, H.W., Schemezer, P. 1993. Assessment of genotoxic effects by lindane. Food Chem toxicol 31: 271-283.
14. Rupa, D.S., Reddy, P.P. Reddy, O.S. 1991. Clatogenic effects of pesticides in peripheral lymphocytes of cotton-field workers. Mut Res 261: 177-180.
15. Schop, R.N., Hardy, M.H., Goldberg, M.T. 1990. Comparison of the activity of topically applied pesticides and the herbicide 2,4-D in two short-term in vivo assays of genotoxicity in the mouse. Fundam Appl Toxicol. 15: 666-675.
16. Scott, D., Galloway, S.M., Marshall, R.R., Ishidate, M. Jr. 1991 Genotoxicity under extreme culture conditions. A report form ICPEMC task Group 9. Mut Res 257: 147-204.
17. Singh, N.P., MC Coy Mt, Tice RR, Shneider El 1988. A simple technique for quantitation of low levels of DNA damage in indivaual cells. Exp Cell Res 157: 184-191.
18. Sreekumaran Nair, R. Paulmurigan R, Ranjith Singh AJA 2002. Simple radioactive assay for the estimation of DNA breaks. J. Appl Toxicol 22: 19-23.
19. Van Loon AAWM, Groenen dijk RH. Van der Shcans Gp Lohman PHM, Baan, R.A. 1991. Detection of induced damage in DNA in human blood exposed to ionic radiation at biologically relevant dozes. Int J Radiat Biol 59: 651-660.
20. Vijayalakshmi, K. 1995. Growth of pesticides-Indian situation. Pesticide Post 3: 4.
21. Vineis, P., Seniori Costantini, A. 1990. Italian multicentre case-control study of hematolyphopoietic malignancies. Med lav 81: 506-512.
22. Vrhovae, G.V., Zeljezic, D. 2000. Evaluation of DNA damage in workers occupationally exposed to pesticides using SCG assay: Pesticide genotoxicity revealed by comet assay. Mut Res 469: 279-285.
23. Vrhovae, GV, Zeljezic, D. 2002. Assessment of genome damage in a population of croatain workers employed in pesticide production by chromosomal aberration analysis, micronucleus assay and Comet assay. J. Appl. Toxicol 22: 249-255.
24. Weisenburger DD 1990. Environmental epidemiology of non-Hodgkin's lymphoma in eatern Nebraska. Am J Ind Med 18: 303-305.
25. Zahm SH 1997. Mortality study of pesticide applicators and other employees of a lawn care service company. Occup Environ Med, 39: 1055-1067.