Frequency of the CCR5-Δ32 mutant allele is not increased in Belgian hepatitis C virus-infected patients

Viral Immunology

Volumn 18, Issue 1, 2005, Pages 232-235

  Thoelen, Inge ^a   Verbeeck, Jannick ^a   Wollants, Elke ^a   Maes, Piet ^a   Robaeys, Geert ^b   Matheï, Cathy ^b   Buntinx, Frank ^b   Nevens, Frederik ^c   Van Ranst, Marc ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ARTICLE; BELGIUM; COHORT ANALYSIS; CONTROLLED STUDY; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INFECTIOUS HEPATITIS; POLYMERASE CHAIN REACTION; RISK FACTOR; STATISTICAL SIGNIFICANCE; GENETICS; MUTATION;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

BELGIUM; COHORT STUDIES; GENE FREQUENCY; GENOTYPE; HEPATITIS C; HUMANS; MUTATION; RECEPTORS, CCR5;

EID: 17844410362     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2005.18.232     Document Type: Article

References (21)

1. Ahlenstiel, G., R.P. Woitas, J. Rockstroh, et al. 2004. CC-chemokine receptor 5 (CCR5) in hepatitis C - at the cross-roads of the antiviral immune response? J. Antimicrob. Chemother. 53:895-898.
2. Apolinario, A., P.L. Majano, E. Alvarez-Perez, et al. 2002. Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease. Am. J. Gastroenterol. 97:2861-2870.
3. De Roda Husman, A.M., M. Koot, M. Cornelissen, et al. 1997. Association between CCR5 genotype and the clinical course of HIV-1 infection. Ann. Intern. Med. 127:882-890.
4. Dean, M., M. Carrington, C. Winkler, et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene, Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 273:1856-1862.
5. Deng, H., R. Liu, W. Ellmeier, et al. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666.
6. Glas, J., H.P. Torok, C. Simperl, et al. 2003. The Delta 32 mutation of the chemokine-receptor 5 gene neither is correlated with chronic hepatitis C nor does it predict response to therapy with interferon-alpha and ribavirin. Clin. Immunol. 108:46-50.
7. Klein, R.S. 2003. Discussion on frequency of the HIV-protective CC chemokine receptor 5-Delta 32/Delta 32 genotype is increased in hepatitis C. Gastroenterology 124:1558.
8. Lench, N., P. Stanier, and R. Williamson. 1988. Simple non-invasive method to obtain DNA for gene analysis. Lancet 1:1356-1358.
9. Lichterfeld, M., L. Leifeld, H.D. Nischalke, et al. 2002. Reduced CC chemokine receptor (CCR) 1 and CCR5 surface expression on peripheral blood T lymphocytes from patients with chronic hepatitis C infection. J. Infect. Dis. 185:1803-1807.
10. Liu, R., W.A. Paxton, S. Choe, et al. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367-377.
11. Mangia, A., R. Santoro, L. D'agruma, et al. 2003. HCV chronic infection and CCR5-delta32/delta32. Gastroenterology 124:868-869.
12. Martinson, J.J., N.H. Chapman, D.C. Rees, et al. 1997. Global distribution of the CCR5 gene 32-basepair deletion. Nat. Genet. 16:100-103.
13. Nguyen, G.T., M. Carrington, J.A. Beeler, et al. 1999. Phenotypic expressions of CCR5-delta32/delta32 homozygosity. J. Acquir. Immune Defic. Syndr. 22:75-82.
14. Poljak, M., K. Seme, I.J. Marin, et al. 2003. Frequency of the 32-base pair deletion in the chemokine receptor CCR5 gene is not increased in hepatitis C patients. Gastroenterology 124:1558-1560.
15. Promrat, K., D.H. McDermott, C.M. Gonzalez, et al. 2003. Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology. 124:352-360.
16. Rice, C.M. 1996. Flaviviridae: the viruses and their replication, pp. 931-960. In: B.N. Fields, D.M. Knipe, and P.M. Howley (eds.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia.
17. Ruiz-Ferrer, M., N. Barroso, G. Antinolo, et al. 2004. Analysis of CCR5-Delta 32 and CCR2-V64I polymorphisms in a cohort of Spanish HCV patients using real-time polymerase chain reaction and fluorescence resonance energy transfer technologies. J. Viral. Hepat. 11:319-323.
18. Saito, I., T. Miyamura, A. Ohbayashi, et al. 1990. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 87:6547-6549.
19. Wasmuth, H.E., A. Werth, T. Mueller, et al. 2004. CC chemokine receptor 5 delta 32 polymorphism in two independent cohorts of hepatitis C virus infected patients without hemophilia. J. Mol. Med. 82:64-69.
20. Woitas, R.P., G. Ahlenstiel, A. Iwan, et al. 2002. Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C. Gastroenterology 122:1721-1728.
21. Zhang, M., J.J. Goedert, and T.R. O'Brien. 2003. High frequency of CCR5-delta32 homozygosity in HCV-infected, HIV-1-uninfected hemophiliacs results from resistance to HIV-1. Gastroenterology 124:867-868.