Long-term high copper intake: Effects on copper absorption, retention, and homeostasis in men

American Journal of Clinical Nutrition

Volumn 81, Issue 4, 2005, Pages 822-828

  Turnlund, Judith R ^a,c   Keyes, William R ^a   Kim, Soon Kyung ^b   Domek, Joseph M ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b Soonchunhyang University   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Absorption; Copper; High copper intake; Homeostasis; Retention; Stable isotope

Indexed keywords

COPPER; STABLE ISOTOPE;

ADULT; ARTICLE; CLINICAL ARTICLE; COPPER BLOOD LEVEL; COPPER METABOLISM; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG ABSORPTION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG RETENTION; DRUG URINE LEVEL; HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; NORMAL HUMAN; NUTRIENT CONTENT; CHEMISTRY; CLINICAL TRIAL; DIET; DOSE RESPONSE; DRUG EFFECT; FECES; HAIR; HEALTH CARE POLICY; INTESTINE ABSORPTION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADULT; COPPER; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FECES; HAIR; HOMEOSTASIS; HUMANS; INFUSIONS, INTRAVENOUS; INTESTINAL ABSORPTION; MALE; MIDDLE AGED; NUTRITION POLICY;

EID: 17844409314     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/81.4.822     Document Type: Article

References (21)

1. Institute of Medicine. Copper. In: Food and Nutrition Board, ed. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press, 2002;224-57.
2. Turnlund JR, Keen CL, Smith RG. Copper status and urinary and salivary copper in young men at three levels of dietary copper. Am J Clin Nutr 1990;51:658-64.
3. Milne DB, Nielsen FH. Effects of a diet low in copper on copper-status indicators in postmenopausal women. Am J Clin Nutr 1996;63:358-64.
4. Turnlund JR, Scott KC, Peiffer GL, Jang AM, Keen CL, Sakanashi TM. Copper status of young men consuming a low copper diet. Am J Clin Nutr 1997;65:72-8.
5. Pratt WB, Omdahl JL, Sorenson JRJ. Lack of effects of copper gluconate supplementation. Am J Clin Nutr 1985;42:681-2.
6. O'Donohue J, Reid MA, Varghese A, Protmann B, Williams R. Micronodular cirrhosis and acute liver failure due to chronic copper self-intoxication. Eur J Gastroenterol Hepatol 1993;5:561-2.
7. Pizzaro F, Olivares M, Uauy R, Contreras P, Rebelo A, Gidi V. Acute gastrointestinal effects of graded levels of copper in drinking water. Environ Health Perspect 1999;107:117-21.
8. 65Cu. Am J Clin Nutr 1989;49:870-8.
9. Harvey LJ, Majask-Newman G, Dainty JR, et al. Adaptive responses in men fed low- and high-copper diets. Br J Nutr 2003;90:161-8.
10. Cashman KD, Baker A, Ginty F, et al. No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status. Eur J Clin Nutr 2001;55:525-31.
11. Turnlund JR, Jacob RA, Keen CL, et al. Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men. Am J Clin Nutr 2004;79:1037-44.
12. 65Cu. Am J Clin Nutr 1998;67: 1219-25.
13. Schutte SA, Janghorbani M, Young VR, Weaver CM. Dysprosium as a nonabsorbable marker for studies of mineral absorption with stable isotope tracers in human subjects. J Am Coll Nutr 1993;12:307-15.
14. Turnlund JR, Keyes WR. Automated analysis of stable isotopes of zinc, copper, iron, calcium, and magnesium by thermal ionization mass spectrometry using double isotope dilution for tracer studies in humans. J Micronutrient Analysis 1990;7:117-45.
15. Keyes WR, Turnlund JR. Determination of molybdenum and enriched Mo stable isotope concentrations in human blood plasma by isotope dilution ICP-MS. J Anal Atomic Spect 2002;17:1153-6.
16. Sabatier M, Keyes WR, Pont F, Arnaud MJ, Turnlund JR. Comparison of stable isotope tracer methods for the determination of magnesium absorption in humans. Am J Clin Nutr 2003;77:1206-12.
17. SAS/STAT Users Guide, Version 8. Cary, NC: SAS Institute, Inc, 1999.
18. Brewer GJ, Yuzbasiyan-Gurkan V. Wilson disease. Medicine 1992;71: 139-64.
19. Pandit A, Bhave S. Present interpretation of the role of copper in Indian child cirrhosis Am J Clin Nutr 1996;63:830S-5S.
20. Vierling JM. Copper metabolism in primary biliary cirrhosis. Semin Liver Dis 1981;1:293-308.
21. Turnlund JR, Domek JM, Nair PP, Bhathena SJ. Copper retention in intestinal mucosal cells of young men at normal and high copper intakes. J Trace Elements Exp Med 2003;16:105-8.