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Morgante L, Epifanio A, Spina E, et al. Quetiapine and clozapine in parkinsonian patients with dopaminergic psychosis. Clin Neuropharmacol 2004; 27:153-156. The efficacy and safety of quetiapine and clozapine in parkinsonian patients with dopaminergic psychosis was studied in a randomized, open-label, blinded-rater, parallel 12 weeks group trial. Forty patients, 20 on clozapine and 20 on quetiapine, completed the study. The psychopathologic state improved significantly in both treatment groups. No differences were found between clozapine and quetiapine at any assessment time. Side effects were mild, generally transient, and well tolerated.
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Fernandez HH, Trieschmann ME, Okun MS. Rebound psychosis: Effect of discontinuation of antipsychotics in Parkinson's disease. Mov Disord 2004; 19:831-833. Psychiatrically stable Parkinson's disease patients with a history of drug-induced psychosis on quetiapine or clozapine were weaned off their antipsychotic drug. After the antipsychotic agent was discontinued, psychosis recurred in five of six patients. In three patients the 'rebound psychosis' was worse than the original psychotic episode and required subsequent higher antipsychotic medication doses.
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