Antibiotic elution from hydroxyapatite cement cranioplasty materials

Journal of Craniofacial Surgery

Volumn 16, Issue 2, 2005, Pages 228-233

  Pietrzak, William S ^a   Eppley, Barry L ^b  

^a Biomet Incorporated   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibiotic; Cranioplasty; Elution; Hydroxyapatite; Tobramycin

Indexed keywords

ANTIBIOTIC AGENT; BIOMATERIAL; BONE CEMENT; HYDROXYAPATITE; PHOSPHATE BUFFERED SALINE; TOBRAMYCIN; ANTIINFECTIVE AGENT; BUFFER; HYDROXYAPATITE CEMENT; PHOSPHATE; SODIUM CHLORIDE;

ARTICLE; BIODEGRADABLE IMPLANT; BONE PROSTHESIS; CRANIOPLASTY; DRUG DELIVERY SYSTEM; DRUG RELEASE; IN VITRO STUDY; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; CHEMISTRY; DIFFUSION; HUMAN; MATERIALS TESTING; TIME;

ANTI-BACTERIAL AGENTS; BIOCOMPATIBLE MATERIALS; BONE CEMENTS; BUFFERS; DIFFUSION; HUMANS; HYDROXYAPATITES; MATERIALS TESTING; PHOSPHATES; SODIUM CHLORIDE; TIME FACTORS; TOBRAMYCIN;

EID: 17844386857     PISSN: 10492275     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001665-200503000-00008     Document Type: Article

References (48)

1. van Ek B, Bakker FP, van Dulken H, Dijkmans BA. Infections after craniotomy: a retrospective study. J Infect 1986;12:105-109
2. Larsson A, Engstrom M, Uusijarvi J, et al. Hyperbaric oxygen treatment of postoperative neurosurgical infections. Neurosurgery 2002;50:287-295
3. Yonehara Y, Hirabayashi S, Sugawara Y, et al. Complications associated with gradual cranial vault distraction osteogenesis for the treatment of craniofacial synostosis. J Craniofac Surg 2003;14:526-528
4. Blomstedt GC. Infections in neurosurgery: a retrospective study of 1143 patients and 1517 operations. Acta Neurochir (Wien) 1985:78:81-90
5. Tokoro K, Chiba Y, Tsubone K. Late infection after cranioplasty-review of 14 cases. Neurol Med Chir (Tokyo) 1989;29:196-201
6. Rasmussen S, Ohrstrom JK. Post-operative infections of osteoplastic compared with free bone flaps. Br J Neurosurg 1990;4: 493-495
7. Wylen EL, Willis BK, Nanda A. Infection rate with replacement of bone fragment in compound depressed bone fractures. Surg Neurol 1999;51:452-457
8. Atanasov DT. A retrospective study of 3326 mandibular fractures in 2252 patients. Folia Med (Plovdiv) 2003;45:38-42
9. Benecke JE Jr. Management of osteomyelitis of the skull base. Laryngoscope 1989;99:1220-1223
10. Chandler JR, Grobman L, Quencer R, Serafini A. Osteomyelitis of the base of the skull. Laryngoscope 1986;96:245-251
11. Cunha BA. Osteomyelitis in elderly patients. Clin Infect Dis 2002;35:287-293
12. Nelson CL, McLaren SG, Skinner RA, et al. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res 2002;20:643-647
13. McKee MD, Wild LM, Schemitsch EH, Waddell JP. The use of an antibiotic-impregnated, osteoconductive, bioabsorbable one substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma 2002;16: 622-627
14. Miclau T, Dahners LE, Lindsey RW. In vitro pharmacokinetics of antibiotic release from locally implantable materials. J Orthop Res 1993;11;627-632
15. Šoltés L. Aminoglycoside antibiotics - two decades of their HPLC bioanalysis. Biomed Chromatagr 1999;13:3-10
16. Blake DP. The use of synthetics in cranioplasty: a clinical review. Mil Med 1994;159:466-469
17. Moreira-Gonzalez A, Jackson IT, Miyawaki T, et al. Clinical outcome in cranioplasty: critical review in long-term follow-up. J Craniofac Surg 2003;14:144-153
18. Eppley BL. Hydroxyapatite cranioplasty: I. Experimental results from a new quick-setting material. J Craniofac Surg 2003; 14:85-88
19. Eppley BL, Hollier L, Stal S. Hydroxyapatite cranioplasty: 2. Clinical experience with a new quick-setting material. J Craniofac Surg 2003;14:209-214
20. Constantino PD, Chaplin JM, Wolpoe ME, et al. Applications of fast-setting hydroxyapatite cement: cranioplasty. Otolaryngol Head Neck Surg 2000;123:409-412
21. Tay BKB, Patel VV, Bradford DS. Calcium sulfate and calcium phosphate-based bone substitutes. Mimicry of the mineral phase of bone. Orthop Clin North Am 1999;30:615-623
22. Hamanishi C, Kitamoto K, Tanaka S, et al. A self-setting TTCP-DCPD apatite cement for release of vancomycin. J Biomed Mater Res 1996;33:139-143
23. Shirtliff ME, Calhoun JH, Mader JT. Experimental osteomyelitis treatment with antibiotic-impregnated hydroxyapatite. Clin Orthop 2002;401:239-247
24. Sasaki S, Ishii Y. Apatite cement containing antibiotics: efficacy in treating experimental osteomyelitis. J Orthop Sci 1999; 4:361-369
25. Itokazu M, Ohno T, Tanemori T, et al. Antibiotic-loaded hydroxyapatite blocks in the treatment of experimental osteomyelitis in rats. J Med Microbiol 1997;46:779-783
26. Korkusuz F, Uchida A, Shinto Y, et al. Experimental implant-related osteomyelitis treated by antibiotic-calcium hydroxyapatite ceramic composites. J Bone Joint Surg Br 1993;75:111-114
27. Cornell CN, Tyndall D, Waller S, et al. Treatment of experimental osteomyelitis with antibiotic-impregnated bone graft substitute. J Orthop Res 1993;11:619-626
28. Yamashita Y, Uchida A, Yamakawa T, et al. Treatment of chronic osteomyelitis using calcium hydroxyapatite ceramic implants impregnated with antibiotic. Int Orthop 1998;22:247-251
29. Saito T, Takeuchi R, Hirakawa K, et al. Slow-releasing potential of vancomycin-loaded porous hydroxyapatite blocks implanted into MRSA osteomyelitis. J Biomed Mater Res 2002; 63:245-251
30. Itokazu M, Matsunaga T, Kumazawa S, Oka M. Treatment of osteomyelitis by antibiotic impregnated porous hydroxyapatite block. Clin Mater 1994;17:173-179
31. Yu D, Wong J, Matsuda Y, et al. Self-setting hydroxyapatite cement: a novel skeletal drug-delivery system for antibiotics. J Pharm Sci 1992;81:529-531
32. Itokazu M, Yang W, Aoki T, et al. Synthesis of antibiotic-loaded interporous hydroxyapatite blocks by vacuum method and in vitro drug release testing. Biomaterials 1998;19:817-819
33. Shinto Y, Uchida A, Korkusuz F, et al. Calcium hydroxyapatite ceramic used as a delivery system for antibiotics. J Bone joint Surg Br 1992;74:600-604
34. Scott CP, Higham PA, Dumbleton JH. Effectiveness of bone cement containing tobramycin. An in vitro susceptibility study of 99 organisms found in infected joint arthroplasty. J Bone Joint Surg Br 1999;81:440-443
35. Rutledge B, Huyette D, Day D, Anglen J. Treatment of osteomyelitis with local antibiotics delivered via bioabsorbable polymer. Clin Orthop 2003;411:280-287
36. McLaren AC, McLaren SG, Nelson CL, et al. The effect of sampling method on the elution of tobramycin from calcium sulfate. Clin Orthop 2002;403:54-57
37. Turner TT, Urban RM, Gitelis S, et al. Radiographic and histologic assessment of calcium sulfate in experimental animal models and clinical use as a resorbable bone-graft substitute, a bone-graft expander, and a method for local antibiotic delivery. J Bone Joint Surg 2001;83-A(Suppl 2 part 1):8-18
38. Nijhof MW, Stallmann HP, Vogely HC, et al. Prevention of infection with tobramycin-containing bone cement or systemic cefazolin in an animal model. J Biomed Mater Res 2000;52:709-715
39. Lawson KJ, Marks KE, Brems J, Rehm S. Vancomycin vs tobramycin elution from polymethylmethacrylate: an in vivo study. Orthopedics 1990;13:521-524
40. Brien WW, Salvati EA, Klein R, et al. Antibiotic impregnated bone cement in total hip arthoplasty. An in vivo comparison of the elution properties of tobramycin and vancomycin. Clin Orthop 1993;296:242-248
41. Szunyog J, Adams E, Roets E, et al. Analysis of tobramycin by liquid chromatography with pulsed electrochemical detection. J Pharm Biomed Anal 2000;23:891-896
42. Lee DD, Tofighi A, Aiolova M, et al. Alpha-BSM: a biomimetic bone substitute and drug delivery vehicle. Clin Orthop 1999;(367 Suppl):S396-S405
43. Richelsoph KC, Petersen DW, Haggard WO, et al. Elution characteristics of tobramycin-impregnated medical grade calcium sulfate hemihydrate. Proceedings from the 44th Annual Meeting of the Orthopaedic Research Society, March 16-19, 1998, Hyatt Regency Hotel, New Orleans, LA, p. 429
44. Goodell JA, Flick AB, Hebert JC, Howe JG. Preparation and release characteristics of tobramycin-impregnated polymethylmethacrylate beads. Am J Hosp Pharm 1986;43:1454-1460
45. Wahlig H, Dingeldein E. Antibiotics and bone cements. Experimental and clinical long-term observations. Acta Orthop Scand 1980;51:49-56
46. Jaberi FM, Shahcheraghi GH, Ahadzadeh M, Short-term intravenous antibiotic treatment of acute hematogenous bone and joint infection in children: a prospective, randomized trial. J Pediatr Orthop 2002;22:317-320
47. Le Saux N, Howard A, Barowman NJ, et al. Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review. BMC Infect Dis 2002;21:16
48. Kanellakopoulou K, Giamarellos-Bourboulis EJ. Carrier systems for the local delivery of antibiotics in bone infections. Drugs 2000;59:1223-1232