Apatite cement containing antibiotics: Efficacy in treating experimental osteomyelitis

Journal of Orthopaedic Science

Volumn 4, Issue 5, 1999, Pages 361-369

  Sasaki, Shigeru ^a   Ishii, Yoshiaki ^a  

^a KYORIN UNIVERSITY   (Japan)

Author keywords

Drug delivery system; Enzyme linked immunosorbent assay (ELISA); Hydroxyapatite; IgG antibody titer; Poly L lactic acid

Indexed keywords

ANTIBIOTIC AGENT; CALCIUM PHOSPHATE; CEMENT; GENTAMICIN; HYDROXYAPATITE; POLYLACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE GROWTH; BONE RADIOGRAPHY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SENSITIVITY; FEMALE; IMPLANT; NONHUMAN; OSTEOMYELITIS; RABBIT; SUSTAINED RELEASE FORMULATION;

EID: 0032700942     PISSN: 09492658     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007760050117     Document Type: Article

References (20)

1. Dekel S, Francis MJO. The treatment of osteomyelitis of the tibia with sodium salicylate: an experimental study in rabbits. J Bone Joint Surg Br 1981;63:178-84.
2. Engvall E, Perlmann P. Enzyme-linked immunosorbent assay, ELISA.III. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. J Immunol 1972; 109:129-35
3. Hamanishi C, Kitamoto K, Yoshii T, et al. Drug delivery system for vancomicin using TECP bioactive cement. J Jpn Orthop Assoc 1994;68:S1601.
4. Hyon S-H, Jamshidi K, Ikeda Y, et al. Bone filler from poly (lactic acid)-hydroxyapatite composites. Kobunshi Ronbunshu 1985;42: 771-6.
5. Itokazu M, Matsunaga T, Kumazawa S, et al. A novel drug delivery system for osteomyelitis using porous hydroxyapatite blocks loaded by centrifugation. J Appl Biomater 1994;2:167-69.
6. Itokazu M, Matsunaga T, Somiya H, et al. Drug delivery systems using porous hydroxyapatite blocks. J Orthop Surg 1995;6:47-50.
7. Jacob E, Arendt DM, Brook I, et al Enzyme-linked immunosorbent assay for detection of antibodies to Staphylococcus aureus cell walls in experimental osteomyelitis. J Clin Microbiol 1985;22: 547-52.
8. Kawauchi T. Studies on penicillin treatment of acute osteomyehtis. J Antibiot 1951;4:4-8 (in Japanese).
9. Kurashina K, Kurita H, Hirano M, et al. Calcium phoshate cement: in vitro and in vivo studies of the α-tricalcium phosphate-dicalcium phosphate dibasic-tetracalcium phosphate monoxide system. J Mater Sci 1995;6:340-7.
10. Kusakabe A, Francis MJO. Experimental osteomyelitis: a description of the model. Seikeigeka (Orthopaedic Surgery) 1983; 34:1933-9 (in Japanese).
11. Müller W. Untersuchungen über Infektion des Knochenmarkes und die Erzeugung eitriger Osteomyelitis. Zentralbl Chir 1930:50: 3132-5.
12. Norden CW, Kennedy E. Experimental osteomyelitis. I. A description of the model. J Infect Dis 1970;122:410-18.
13. Scheman L, Janota M, Lewin P. The production of experimental ostomyelitis. Preliminary report. JAMA 1941;117:1525-9.
14. Shimoda M. Research on insertion of antibiotic-containing ceramics into bone. J Kyorin Med 1995;26:5-13 (in Japanese).
15. Shinto Y, Uchida A, Korkusuz F, et al. Calcium hydroxyapatite ceramic used as a delivery system for antibiotics. J Bone Joint Surg Br 1992:74:600-4.
16. Sugiyama Y. An experimental study on pyogenic osteomyelitis, especially for the production of experimental osteomyelitis in rabbits. J Jpn Orthop Assoc 1970;44:253-69 (in Japanese).
17. Takano I. Ishii Y. Experimental study of apatite cement containing antibiotics. J Orthop Sci 1997;2:98-105.
18. Ueno H. A study on experimental pyogenic osteomyelitis: especially the production of experimental osteomyelitis in mice. J Jpn Orthop Assoc 1974;48:291-301 (in Japanese).
19. Wei G, Kotoura Y, Oka M, et al. A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier. J Bone Joint Surg Br 1991;73:246-52.
20. Japan Society of Chemotherapy, Committee for Revision of Minimum Inhibitory Concentration. Revision for minimum inhibitory concentration (MIC). Chemotherapy 1981;29:76-9 (in Japanese).