Risk prediction in patients with chest pain: Early assessment by the combination of troponin I results and electrocardiographic findings

Coronary Artery Disease

Volumn 16, Issue 3, 2005, Pages 181-189

  Eggers, Kai M ^a   Oldgren, Jonas ^a   Nordenskjöld, Anna ^a   Lindahl, Bertil ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Admission electrocardiogram; Chest pain; Coronary heart disease; Point of care testing; Troponin

Indexed keywords

TROPONIN I;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; ECG ABNORMALITY; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW UP; HEART DEATH; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART REINFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; ST SEGMENT DEPRESSION; THORAX PAIN;

AGED; ANGINA, UNSTABLE; BIOLOGICAL MARKERS; CHEST PAIN; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; OUTCOME ASSESSMENT (HEALTH CARE); PROGNOSIS; RECURRENCE; RISK ASSESSMENT; TROPONIN I;

EID: 17844386334     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-200505000-00008     Document Type: Article

References (26)

1. Antman EM, Tanasijevic MJ, Thompson B, Schactman M, McCabe CH, Cannon CP, et al. Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 1996; 335:1342-1349.
2. Ohman EM, Armstrong PW, Christenson RH, Granger CB, Katus HA, Hamm CW, et al. Cardiac troponin T levels for risk stratification in acute myocardial ischemia. N Engl J Med 1996; 335:1333-1341.
3. Hamm CW, Goldmann BU, Heeschen C, Kreymann G, Berger J, Meinertz T. Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin I or T. N Engl J Med 1997; 337:1648-1653.
4. Lindahl B, Diderholm E, Lagerqvist B, Venge P, Wallentin L and the FRISC II investigators. Mechanisms behind the prognostic value of troponin T in unstable coronary artery disease: a FRISC II substudy. J Am Coll Cardiol 2001; 38:979-986.
5. Apple FS, Murakami MM, Jesse RL, Levitt MA, Berger AK, Pearce LA, et al. Near-bedside whole-blood cardiac troponin I assay for risk assessment of patients with acute coronary syndromes. Clin Chem 2002; 48:1784-1787.
6. Venge P, Lagerqvist B, Diderholm E, Lindahl B, Wallentin L, on behalf of the FRISC II Study Group. Clinical performance of three cardiac troponin assays in patients with unstable coronary artery disease (a FRISC II substudy). Am J Cardiol 2002; 89:1035-1041.
7. James S, Armstrong P, Califf R, Simoons ML, Venge P, Wallentin L, et al. Troponin T levels and risk of 30-day outcomes in patients with acute coronary syndrome: prospective verification in the GUSTO-IV trial. Am J Med 2003; 115:178-184.
8. Alpert JS, Thygesen A, Antman EM, Bassand JP. Myocardial infarction redefined - a consensus document of the joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. J Am Coll Cardiol 2000; 36:959-969.
9. Braunwald E, Antman EM, Beasley JW, Califf RM, Cheitlin MD, Hochman JS, et al. ACC/AHA guidelines for the management of patients with unstable angina and non-ST segment elevation myocardial infarction: executive summary and recommendations. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina). Circulation 2000; 102:1193-1209.
10. Heeschen C, Goldmann BU, Langenbrink L, Matschuk G, Hamm CW. Evaluation of a rapid whole blood ELISA for quantification of troponin I in patients with acute chest pain. Clin Chem 1999; 45:1789-1796.
11. Newby LK, Storrow AB, Gibler WB, Garvey JL, Tucker JF, Kaplan AL, et al. Bedside multimarker testing for risk stratification in chest pain units: The chest pain evaluation by creatine kinase-MB, myoglobin, and troponin I (CHECKMATE) study. Circulation 2001; 103:1832-1837.
12. McCord J, Nowak RM, Hudson MP, McCullough PA, Tomlanovich MC, Jacobsen G, et al. The prognostic significance of serial myoglobin, troponin I, and creatine kinase-MB measurements in patients evaluated in the emergency department for acute coronary syndrome. Ann Emerg Med 2003; 42:343-350.
13. Panteghini M, Pagani F, Yeo KT, Apple FS, Christenson RH, Dati F, et al. Evaluation of imprecision for cardiac troponin assays at low-range concentrations. Clin Chem 2004; 50:327-332.
14. Apple FS, Wu AH, Jaffe AS. European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: How to use existing assays clinically and for clinical trials. Am Heart J 2002; 144:981-986.
15. Altinier S, Mion M, Cappelletti A, Zaninotto M, Plebani M. Rapid measurement of cardiac markers on Stratus CS. Clin Chem 2000; 46:991-993.
16. Ohman EM, Armstrong PW, White HD, Granger CB, Wilcox RG, Weaver WD, et al. Risk stratification with a point-of-care cardiac troponin T test in acute myocardial infarction. GUSTO III Investigators. Global Use of Strategies To Open Occluded Coronary Arteries. Am J Cardiol 1999; 84:1281-1286.
17. La Vecchia L, Mezzena G, Zanolla L, Paccanaro M, Varotto L, Bonanno C, et al. Cardiac troponin I as diagnostic and prognostic marker in severe heart failure. J Heart Lung Transplant 2000; 19:644-652.
18. Horwich TB, Patel J, MacLellan R, Fonarow GC. Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction and increased mortality rates in advanced heart failure. Circulation 2003; 108:833-838.
19. Konstantinides K, Geibel A, Olschewski M, Kasper W, Hruska N, Jäckle S, et al. Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism. Circulation 2002; 106:1263-1268.
20. Ammann P, Maggiorini M, Bertel O, Haenseler E, Joller-Jemelka HI, Oechslin E, et al. Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes. J Am Coll Cardiol 2003; 41:2004-2009.
21. Bakshi TK, Choo MK, Edwards CC, Scott AG, Hart HH, Armstrong GP. Causes of elevated troponin I with a normal coronary angiogramm. Intern Med J 2002; 32:520-525.
22. Eggers KM, Oldgren J, Nordenskjöld A, Lindahl B. Diagnostic value of serial measurement of cardiac markers in patients with chest pain - limited value of adding myoglobin to troponin I for exclusion of myocardial infarction. Am Heart J 2004; 148:574-581.
23. Savonitto S, Ardissino D, Granger CB, Morando G, Prando MD, Mafrici A, et al. Prognostic value of the admission electrocardiogram in acute coronary syndromes. JAMA 1999; 281:707-713.
24. Cannon CP, McCabe CH, Stone PH, Rogers WJ, Schactman M, Thompson BW, et al. The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q wave myocardial infarction: results of the TIMI III registry ECG ancillary study. Thrombolysis in myocardial ischemia. J Am Coll Cardiol 1997; 30:133-140.
25. Hyde TA, French JK, Cheuk-Kit W, Straznicky IT, Whitlock RML, White HD. Four-year survival of patients with acute coronary syndromes without ST-segment elevation and prognostic significance of 0.5-mm ST-segment depression. Am J Cardiol 1999; 84:379-385.
26. Jernberg T, Lindahl B. A combination of troponin T and 1 2-lead electrocardiography: a valuable tool for early prediction of long-term mortality in patients with chest pain without ST-segment elevation. Am Heart J 2002; 144:804-810.