Apolipoprotein E polymorphism and the distribution profile of very low density lipoproteins; an influence of the E4 allele on large (Sf > 60) particles

Atherosclerosis

Volumn 138, Issue 1, 1998, Pages 207-215

  Bioletto, S ^a   Fontana, P ^b   Darioli, R ^b   James, R W ^a  

^a UNIVERSITY HOSPITAL   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Apolipoprotein E; Atherosclerosis; Familial hypercholesterolaemia; Genetic polymorphism; Lipoproteins; Statin; VLDL

Indexed keywords

APOLIPOPROTEIN E;

ADULT; ALLELE; ARTICLE; CLINICAL ARTICLE; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; LIPID COMPOSITION; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; MALE; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 17744420097     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(98)00002-1     Document Type: Article

References (48)

1. Packard CJ, Munro A, Lorimer AR, Gotto AM, Shepherd J Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects. J Clin Invest. 74:1984;2178-2192.
2. Eisenberg S, Gavish D, Oschry Y, Fainaru M, Deckelbaum RJ Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment. J Clin Invest. 74:1984;470-482.
3. Musliner TA, McVicker KM, Iosefa JF, Krauss RM Metabolism of human intermediate and very low density lipoprotein subfractions from normal and dysbetalipoproteinemic plasma. In vivo studies in rat. Arteriosclerosis. 7:1987;408-420.
4. Bradley WA, Gianturco SH Triglyceride-rich lipoproteins and atherosclerosis: Pathophysiological considerations. J Intern Med (Suppl). 736:1994;33-39.
5. Packard CJ, Gaw A, Demant T, Shepherd J Development and application of a multicompartmental model to study very low density lipoprotein subfraction metabolism. J Lipid Res. 36:1995;172-187.
6. Packard CJ, Shepherd J, Joerns S, Gotto AM Jr, Taunton OD Very low density and low density lipoprotein subfractions in type III and type IV hyperlipoproteinemia. Chemical and physical properties. Biochim Biophys Acta. 572:1979;269-282.
7. Kandoussi A, Cachera C, Parsy D, Bard JM, Fruchart JC Quantitative determination of different apolipoprotein B containing lipoproteins by an enzyme linked immunosorbent assay: Apo B with apo C-III and apo B with apo E. J Immunoassay. 12:1991;305-323.
8. Gianturco SH, Bradley WA, Nozaki S, Vega GL, Grundy SM Effects of lovastatin on the levels, structure, and atherogenicity of VLDL in patients with moderate hypertriglyceridemia. Arterioscler Thromb. 13:1993;472-481.
9. Beisiegel U Receptors for triglyceride-rich lipoproteins and their role in lipoprotein metabolism. Curr Opin Lipidol. 6:1995;117-122.
10. Brewer HB, Zech LA, Gregg RE, Schwartz D, Schaefer EJ Type III hyperlipoproteinemia: Diagnosis, molecular defects, pathology and treatment. Ann Intern Med. 98:1983;623-640.
11. Evans AJ, Huff MW, Wolfe BM Accumulation of an apo E-poor subfraction of very low density lipoprotein in hypertriglyceridemic men. J Lipid Res. 30:1989;1691-1701.
12. Leowsky J, James RW, Taton J, Pometta D The influence of metabolic control on very low density lipoprotein composition in hypertriglyceridemic type II diabetics. A study using heparin-Sepharose chromatography. Metabolism. 37:1988;721-726.
13. Yang C-Y, Gu Z-W, Valentinova N, Pownall HJ, Lee B, Yang M, Xie Y-H, Guyton JR, Vlasik TN, Fruchart J-C Human very low density lipoprotein structure: Interaction of the C apolipoproteins with apolipoprotein B. J Lipid Res. 34:1993;1311-1322.
14. Fielding PE, Fielding CJ An apo-E-free very low density lipoprotein enriched in phosphatidylethanolamine in human plasma. J Biol Chem. 261:1986;5233-5236.
15. Yamada N, Shames DM, Havel RJ Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits. J Clin Invest. 80:1987;507-515.
16. Ehnholm C, Mahley RW, Chappell DA, Weisgraber KH, Ludwig E, Witztum JL. Role of apolipoprotein E in the lipolytic conversion of β-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia. Proc Natl Acad Sci USA. 81:1984;5566-5570.
17. Evans AJ, Wolfe BM, Strong WL, Huff MW Reduced lipolysis of large apo E-poor very-low-density lipoprotein subfractions from type IV hypertriglyceridemic subjects in vitro and in vivo. Metabolism. 42:1993;105-115.
18. Kinoshita M, Arai H, Fukasawa M, Watanabe T, Tsukamoto K, Hashimoto Y, Inoue K, Kurokawa K, Teramoto T Apolipoprotein E enhances lipid exchange between lipoproteins mediated by cholesteryl ester transfer protein. J Lipid Res. 34:1993;261-268.
19. Davignon J, Gregg RE, Sing CF Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 8:1988;1-21.
20. Hallman DM, Boerwinkle E, Saha N, Sandholzer C, Menzel HJ, Csazar A, Utermann G The apolipoprotein E polymorphism: A comparison of allele frequencies and effects in nine populations. Am J Hum Genet. 49:1991;338349.
21. Cumming AM, Robertson FW Polymorphism at the apoprotein-E locus in relation to risk of coronary disease. Clin Genet. 25:1984;310-313.
22. Wilson PW, Myers RH, Larson MG, Ordovas JM, Wolf PA, Schaefer EJ Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study. J Am Med Assoc. 272:1994;1666-1671.
23. Steinmetz A, Jakobs C, Motzny S, Kaffarnik H Differential distribution of apolipoprotein E isoforms in human plasma lipoproteins. Arteriosclerosis. 9:1989;405-411.
24. Dong LM, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J Biol Chem. 269:1994;22358-22365.
25. Luc G, Ducimetiere P, Bard J-M, Arveiler D, Evans A, Cambien F, Fruchart J-C, Fievet C Distribution of apolipoprotein E between apo B- and non apo B-containing lipoproteins according to apo E phenotype. Atherosclerosis. 131:1997;257-262.
26. James RW, Hochstrasser D, Tissot J-D, Funk M, Appel R, Barja F, Pellegrini C, Muller AF, Pometta D Protein heterogeneity of lipoprotein particles containing apolipoprotein A-I without apolipoprotein A-II and apolipoprotein A-I with apolipoprotein A-II, isolated from human plasma. J Lipid Res. 29:1988;1557-1571.
27. Borghini I, Barja F, Pometta D, James RW Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid. Biochim Biophys Acta. 1255:1995;192-200.
28. Lindgren FT, Jensen LC, Hatch FT The isolation and quantitative analysis of serum lipoproteins. Nelson GJ Blood Lipids and Lipoproteins; Quantitation, Composition, and Metabolism. 1972;181-274 Wiley-Interscience, New York.
29. James RW, Pometta D Differences in lipoprotein subfraction composition and distribution between type 1 diabetic men and control subjects. Diabetes. 39:1990;1158-1164.
30. James RW, Pometta D The distribution profiles of very low density and low density lipoproteins in poorly-controlled male, type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 34:1991;246-252.
31. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ Protein measurement with the Folin phenol reagent. J Biol Chem. 193:1951;265-275.
32. Hixson JE, Vernier DT Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res. 31:1990;545548.
33. Sambrook J, Fritsch EF, Maniatis T Molecular Cloning. A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press.
34. Yang CY, Gu ZW, Xie YH, Valentinova NV, Yang M, Yeshurun D, Quion JA, Gotto AM Jr Effects of gemfibrozil on very-low-density lipoprotein composition and low-density lipoprotein size in patients with hypertriglyceridemia or combined hyperlipidemia. Atherosclerosis. 126:1996;105-116.
35. Gibson JC, Rubinstein A, Ginsberg HN, Brown WV Isolation of apolipoprotein E-containing lipoproteins by immunoaffinity chromatography. Methods Enzymol. 129:1986;186-198.
36. Campos E, Jackle S, Chi Chen G, Havel RJ Isolation and characterization of two distinct species of human very low density lipoproteins lacking apolipoprotein E. J Lipid Res. 37:1996;1897-1906.
37. Blum CB, Aron L, Sciacca R Radioimmunoassay studies of human apolipoprotein E. J Clin Invest. 66:1980;1240-1250.
38. Castro GR, Fielding CJ Evidence for the distribution of apolipoprotein E between lipoprotein classes in human normocholesterolemic plasma and for the origin of unassociated apolipoprotein E (Lp-E). J Lipid Res. 25:1984;58-67.
39. McConathy WJ, Koren E, Wieland H, Campos EM, Lee DM, Kloer HU, Alaupovic P Evaluation of immunoaffinity chromatography for isolating human lipoproteins containing apolipoprotein B. J Chromatogr. 342:1985;46-66.
40. Nikkila M, Pitkajarvi T, Koivula T, Solakivi T, Lehtimaki T, Laippala P, Jokela H, Lehtomaki E, Seppa K, Sillanaukee P Women have a larger and less atherogenic low density lipoprotein particle size than men. Atherosclerosis. 119:1996;181-190.
41. Bredie SJ, Vogelaar JM, Demacker PN, Stalenhoef AF Apolipoprotein E polymorphism influences lipid phenotypic expression, but not the low density lipoprotein subfraction distribution in familial combined hyperlipidemia. Atherosclerosis. 126:1996;313-324.
42. Bohnet K, Pillot T, Visvikis S, Sabolovic N, Siest G Apolipoprotein (apo) E genotype and apo E concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors. J Lipid Res. 37:1996;1316-1324.
43. Gianturco SH, Brown FB, Gotto AM Jr, Bradley WA Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts. J Lipid Res. 23:1982;984-993.
44. Chappell DA, Fry GL, Waknitz MA, Muhonen LE, Pladet MW Low density lipoprotein receptors bind and mediate cellular catabolism of normal very low density lipoproteins in vitro. J Biol Chem. 268:1993;25487-25493.
45. Demant T, Bedford D, Packard CJ, Shepherd J Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects. J Clin Invest. 88:1991;1490-1501.
46. Carlson TL, Kottke BA Effect of 25-hydroxycholesterol and bile acids on the regulation of cholesterol metabolism in HepG2 cells. Biochem J. 264:1989;241-247.
47. Felgines C, Serougne C, Mathe D, Mazur A, Lutton C Effect of simvastatin treatment on plasma apolipoproteins and hepatic apolipoprotein mRNA levels in the genetically hypercholesterolemic rat (RICO). Life Sci. 54:1994;361-367.
48. Utermann G. The apo E-system: Genetic control of plasma lipoprotein concentration. Adv Exp Med Biol. 201:1986;261-272.