Apolipoprotein E polymorphism influences lipid phenotypic expression, but not the low density lipoprotein subfraction distribution in familial combined hyperlipidemia

Atherosclerosis

Volumn 126, Issue 2, 1996, Pages 313-324

  Bredie, S J H ^a   Vogelaar, J M ^a   Demacker, P N M ^a   Stalenhoef, A F H ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apolipoprotein E polymorphism; Familial combined hyperlipidemia; Genetics; Phenotypic expression

Indexed keywords

APOLIPOPROTEIN E; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FAMILIAL HYPERLIPEMIA; FEMALE; GENETIC POLYMORPHISM; HUMAN; HUMAN TISSUE; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL;

EID: 0030601668     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(96)05924-2     Document Type: Article

References (41)

1. Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest. 52:1973;1544.
2. Rose HG, Kranz P, Weinstock M, Juliano J, Haft JI Inheritance of combined hyperlipoproteinemia: evidence for a new lipoprotein phenotype. Am J Med. 54:1973;148.
3. Grundy SM, Chait A, Brunzell JD Familial combined hyperlipidemia workshop. Arteriosclerosis. 7(2):1987;203.
4. Kissebah AH, Alfarsi S, Adams PW Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein-B kinetics in man: normolipidemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia. Metabolism. 30(9):1981;856.
5. Venkatesan S, Cullen P, Pacy P, Halliday D, Scott J Stable isotopes show a direct relation between VLDL apoB overproduction and serum triglyceride levels and indicate a metabolically and biochemically coherent basis for familial combined hyperlipidemia. Arterioscler Thromb. 13:1993;1110.
6. Babirak SP, Brown BG, Brunzell JD Familial combined hyperlipidemia and abnormal lipoprotein lipase. Arterioscler Thromb. 12:1992;1176.
7. Hoffer MJ, Bredie SJH, Boomsma DIet al. The lipoprotein lipase (Asn291-Ser) mutation is associated with elevated lipid levels in familial combined hyperlipidemia. Atherosclerosis. 119:1996;159.
8. Smit M, de Knijff P, Rosseneu Met al. Apolipoprotein E polymorphism in The Netherlands and its effect on plasma lipid and apolipoprotein levels. Hum Genet. 80:1988;287.
9. Hallman DM, Boerwinkle E, Saha Net al. The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. Am J Hum Genet. 49:1991;338.
10. Ehnholm C, Lukka M, Kuusi T, Nikkila EA, Utermann G Apolipoprotein E phenotype polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J Lipid Res. 27:1986;227.
11. Utermann G Apolipoprotein E polymorphism in health and disease. Am Heart J. 113:1987;433.
12. Sing CF, Davignon J Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet. 37:1985;268.
13. Brenninkmeijer BJ, Stuyt PMJ, Demacker PNM, Stalenhoef AFH, van't Laar A Catabolism of chylomicron remnants in normolipidemic subjects in relation to the apoprotein E phenotype. J Lipid Res. 28:1987;361.
14. Ferrieres J, Sing CF, Roy M, Davignon J, Lussier-Cacan S Apolipoprotein E polymorphism and heterozygous familial hypercholesterolemia. Sex-specific effects. Arterioscler Thromb. 14:1994;1553.
15. Reilly SL, Ferrell RE, Kottke BA, Kamboh MI, Sing CF The gender-specific apolipoprotein E genotype influence on the distribution of lipids and apolipoproteins in the population of Rochester MN. I. Pleiotropic effects on means and variances. Am J Hum Genet. 49:1991;1155.
16. Reilly SL, Ferrell RE, Kottke BA, Sing CF The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota. II. Regression relationships with concomitants. Am J Hum Genet. 51:1992;1311.
17. Assmann G, Schulte H. Results and conclusions of the prospective cardiovascular Munster (PROCAM) study. In: Assman G (ed). Lipid Metabolism Disorders and Cardiovascular Disease. Munchen: MMV-Medizin-Verlag GmbH, 1993:19-68.
18. Demacker PNM, Hijmans AG, Vos-Jansse HE, van't Laar A, Jansen AP A study of the use of polyethylene glycol in estimating cholesterol in high-density lipoprotein. Clin Chem. 26:1980;1775.
19. Lowry OH, Rosebrough NH, Farr AL, Randall RJ Protein measurement with the folin phenol reagent. Clin Chem. 193:1951;265.
20. Lopes-Virella MF, Virella G, Evans G, Malenkos SB, Colwell JA Immunonephelometry assay of human apolipoprotein AI. Clin Chem. 26:1980;1205.
21. Weidman SW, Suarez B, Falko JMet al. Type III hyperlipoproteinemia: development of a VLDL ApoE gel isoelectric focusing technique and application in family studies. J Lab Clin Med. 93:1979;549.
22. Hixson JE, Vernier DT Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res. 31:1990;545.
23. Swinkels DW, Demacker PNM, Hendriks JCM, van't Laar A Low density lipoprotein subfractions and relationship to other risk factors for coronary artery disease in healthy individuals. Arteriosclerosis. 9:1989;604.
24. de Graaf J, Swinkels DW, De Haan AFJ, Demacker PNM, Stalenhoef AFH Both inherited susceptibility and environmental exposure determine the low density lipoprotein subfraction pattern distribution in healthy Dutch families. Am J Hum Genet. 51:1992;1295.
25. Lipid Research Clinics Program Epidemiology Committee Plasma lipid distributions in selected North American populations: the Lipid Research Clinics Program prevalence study. Circulation. 60:1979;427.
26. Utermann G, Vogelberg KH, Steinmetz Aet al. Polymorphism of apolipoprotein E. II. Genetics of hyperlipoproteinemia type III. Clin Genet. 15:1979;37.
27. Haffner SM, Kushwaha RS, Hazzard WR Metabolism of apolipoprotein B in members of a family with accelerated atherosclerosis: influence of apolipoprotein E-3/E-2 pattern. Metabolism. 41:1992;241.
28. Dallongeville J, Roy M, Leboeuf N, Xhignesse M, Davignon J, Lussier-Cacan S Apolipoprotein E polymorphism association with lipoprotein profile in endogenous hypertriglyceridemia and familial hypercholesterolemia. Arterioscler Thromb. 11:1991;272.
29. Sijbrands EJ, Westendorp RG, Hoffer MJet al. Effect of insulin resistance apoE2 allele, and smoking on combined hyperlipidemia. Arterioscler Thromb. 14:1994;1576.
30. Lussier-Cacan S, Bouthillier D, Davignon J Apo E allele frequency in primary endogenous hypertriglyceridemia (type IV) with and without hyperapobetalipoproteinemia. Arteriosclerosis. 5:1985;639.
31. Houlston R, Lewis B, Humphries SE Polymorphisms of the apolipoprotein B and E genes and their possible roles in familial and non-familial combined hyperlipidaemia. Dis Markers. 9:1991;319.
32. Cumming AM, Robertson FW Polymorphism at the apoprotein-E locus in relation to risk of coronary disease. Clin Genet. 25:1984;310.
33. Menzel HJ, Kladetzky RG, Assmann G Apolipoprotein E polymorphism and coronary artery disease. Arteriosclerosis. 3:1983;310.
34. Brunzell JD, Albers JJ, Chait A, Grundy SM, Groszek E, McDonald GB Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia. J Lipid Res. 24:1983;147.
35. Stalenhoef AFH, Demacker PNM, Lutterman JA, van't Laar A Plasma lipoproteins, apolipoproteins, and triglyceride metabolism in familial hypertriglyceridemia. Arteriosclerosis. 6:1986;387.
36. Kleinveld HA, Demacker PNM, De Haan AFJ, Stalenhoef AFH Decreased in vitro oxidizability of low-density lipoprotein in hypercholesterolaemic patients treated with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors. Eur J Clin Invest. 23:1993;289.
37. de Graaf J, Hak-Lemmers HLM, Hectors MPC, Demacker PNM, Hendriks JCM, Stalenhoef AFH Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects. Arterioscler Thromb. 11:1991;298.
38. Austin MA, Brunzell JD, Fitch WL, Krauss RM Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia. Arteriosclerosis. 10:1990;520.
39. Hokanson JE, Austin MA, Zambon A, Brunzell JD Plasma triglyceride and LDL heterogeneity in familial combined hyperlipidemia. Arterioscler Thromb. 13:1993;427.
40. Bredie SJH, de Bruin TWA, Demacker PNM, Kastelein JJP, Stalenhoef AFH Comparison of gemfibrozil versus simvastatin in familial combined hyperlipidemia and effects on apolipoprotein-B-containing lipoproteins, low-density lipoprotein subfraction profile, and low-density lipoprotein oxidizability. Am J Cardiol. 75:1995;348.
41. Bredie SJH, Kiemeney LA, De Haan AFJ, Demacker PNM, Stalenhoef AFH Inherited susceptibility determines the distribution of dense low density lipoprotein subfraction profiles in familial combined hyperlipidemia. Am J Hum Genet. 58:1996;812.