High-resolution magic-angle spinning 13C NMR spectroscopy of cerebral tissue

Magnetic Resonance Materials in Physics, Biology and Medicine

Volumn 18, Issue 1, 2005, Pages 51-56

  Griffin, J L ^a   Corcoran, O ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cerebral metabolism; Metabolic compartmentation; Pyruvate carboxylase; Pyruvate dehydrogenase

Indexed keywords

LACTIC ACID; LIPID; N ACETYLASPARTIC ACID; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE;

ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; BRAIN TISSUE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; FEMALE; GLIA CELL; METABOLITE; NEUROIMAGING; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TISSUE SECTION;

ALGORITHMS; ANIMALS; BRAIN; CARBON ISOTOPES; FEMALE; GLUCOSE; GLUTAMIC ACID; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; NERVE TISSUE PROTEINS; NEUROTRANSMITTER AGENTS; RATS; SIGNAL PROCESSING, COMPUTER-ASSISTED; SPIN LABELS;

EID: 17744398646     PISSN: 09685243     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10334-004-0094-0     Document Type: Article

References (20)

1. Brainard JR, Kyner E, Rosenberg GA (1989) 13C nulear magnetic resonance evidence for γ-aminobutyric acid formation via pyruvate carboxylase in ratbrain: a metabolic basis for compartmentation. J Neurochem 53:1285-1292
2. Shank RP, Leo GC, Zielke HR (1993) Cerebral metabolic compartmentation as revealed by nuclear magnetic resonance analysis of D-[1-13C]glucose metabolism. J Neurochem 61(1):315-323
3. 2-fixing enzymes in the metabolism of rat brain. J Neurochem 22(5):717-724
4. Millis KK, Maas WE, Cory DG, Singer S (1997) Gradient, high-resolution, magic-angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue. Magn Reson Med 38(3):399-403
5. Cheng LL, Lean CL, Bogdanova A, Wright SC Jr, Ackerman JL, Brady TJ, Garrido L (1996) Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic-angle spinning. Magn Reson Med 36(5):653-658
6. Tomlins AM, Foxall PJ, Lynch MJ, Parkinson J, Everett JR, Nicholson JK (1998) High resolution 1H NMR spectroscopic studies on dynamic biochemical processes in incubated human seminal fluid samples. Biochim Biophys Acta 1379(3):367-380
7. Andrew ER, Eades RG (1959) Removal of dipolar broadening of NMR spectra of solids by specimen rotation. Nature 183:1802
8. Bachelard HS, Badar-Goffer RS (1993) NMR spectroscopy in neurochemistry. J Neurochem 61:412-429
9. McIlwain H, Bachelard HS (1985) Biochemistry and the central nervous system, 5th edn. Churchill-Livingstone, Edinburgh, pp. 40-41, 54-59
10. Passonneau JV, Lowry OH (1993) Enzymatic analysis, chap 6. The Humana, New Jersey
11. Bradford HF (1968) Carbohydrate and energy metabolism. In: Handbook of neurochemistry. Davidson AN, Dobbing J (eds) Blackwell, Oxford, pp 222-250
12. Griffin JL, Rae C, Radda GK, Matthews PM (1999) Delayed labelling of brain glutamate after an intra-arterial [13C]glucose bolus: evidence for aerobic metabolism of guinea pig brain glycogen store. Biochim Biophys Acta 1450(3):297-307
13. Shaka AJ, Keeler J, Freeman R (1983) Evaluation of a new broadband decoupling sequence: WALTZ-16. J Magn Reson 53:313-340
14. Badar-Goffer RS, Bachelard HS, Morris PG (1990) Cerebral metabolism of acetate and glucose studied by 13C-n.m.r. spectroscopy. A technique for investigating metabolic compartmentation in the brain. Biochem J 266(1):133-139
15. Badar-Goffer RS, Ben-Yoseph O, Bachelard HS, Morris PG (1992) Neuronal-glial metabolism under depolarizing conditions. A 13C-n.m.r. study. Biochem J 282 (Pt 1):225-230
16. Sibson NR, Dhankhar A, Mason GF, Behar KL, Rothman DL, Shulman RG (1997) In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proc Natl Acad Sci USA 94(6):2699-2704
17. Ben-Yoseph O, Badar-Goffer RS, Morris PG, Bachelard HS (1993) Glycerol 3-phosphate and lactate as indicators of the cerebral cytoplasmic redox state in severe and mild hypoxia respectively: a 13C and 31P NMR study. Biochem J 291:915-919
18. Millis K, Weybright P, Campbell N, Fletcher JA, Fletcher CD, Cory DG, Singer S (1998) Classification of human liposarcoma and lipoma using ex vivo proton NMR spectroscopy. Magn Reson Med 41(2):257-267
19. Kauppinen RA, Williams SR (1991) Nondestructive detection of glutamate by 1H nuclear magnetic resonance spectroscopy in cortical brain slices from the guinea pig: evidence for changes in detectability during severe anoxic insults. J Neurochem 57(4):1136-1144
20. Kauppinen RA, Pirttila TR (1994) Auriola SO, Williams SR Compartmentation of cerebral glutamate in situ as detected by 1H/13C n.m.r. Biochem J 298 (Pt 1):121-127