A transient dephosphorylation of JAK1 and JAK2 characterises the early-phase response of murine erythroleukemia cells to the differentiation inducer hexamethylenebisacetamide

Leukemia

Volumn 14, Issue 12, 2000, Pages 2112-2117

  Arcangeli, A ^a   Fontana, L ^a   Crociani, O ^a   Cherubini, A ^a   Hofmann, G ^a   Piccini, E ^a   Polvani, S ^a   D'Amico, M ^a   Carla M ^a   Olivotto, M ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

JAK1; JAK2; Leukemia cell differentiation; MELC; STAT5

Indexed keywords

HEXAMETHYLENEBISACETAMIDE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STAT3 PROTEIN; STAT5 PROTEIN; VANADATE SODIUM;

ANIMAL CELL; ARTICLE; CANCER THERAPY; CELL CLONE; CELL DIFFERENTIATION; CONTROLLED STUDY; DEPHOSPHORYLATION; DOWN REGULATION; ERYTHROLEUKEMIA CELL; EXPOSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

EID: 17744388544     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401936     Document Type: Article

References (27)

1. Chemically induced murine erythroleukemic differentiation
2. Differentiating factors
3. Induced differentiation, the cell cycle, and the treatment of cancer
4. Polar/apolar compounds induce leukemia cell differentiation by modulating cell-surface potential
5. Adsorption properties of polar/apolar inducers at a charged interface and their relevance to leukemia cell differentiation
6. Electric fields at the plasma membrane level: A neglected element in the mechanisms of cell signalling
7. Alteration of phosphotyrosine-containing proteins at the early stage of erythroid differentiation of mouse erythroleukemia (MEL) cells
8. Induction of in vitro differentiation of mouse erythroleukemia cells by genistein, an inhibitor of tyrosine protein kinases
9. Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse erythroleukemia cells
10. Cytokine receptor signalling
11. Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor
12. Cell surface site for mitogenic interaction of erythropoietin receptors with the membrane glycoprotein encoded by Friend erythroleukemia virus
13. Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells
14. Inhibition of acute lymphoblastic leukemia by a JAK-2 inhibitor
15. A possible involvement of STAT5 in erythropoietin-induced hemoglobin synthesis
16. Differentiation inducers modulate cytokine signalling pathways in a murine erythroleukemia cell line
17. + channels
18. Characteristics of ether-linked glycerophospholipids in Friend erythroleukemia cells differentiated by dimethysulfoxide or hexamethylenebisacetamide and in non-inducible clones treated with the inducers
19. Differentiation in erythroleukemic cells and their somatic hybrids
20. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
21. Inhibition of protein phosphorylation modulates expression of the JAK family protein tyrosine kinases
22. Activated Ki-Ras complements erythropoietin signalling in CTLL-2 cells, inducing tyrosine phosphorylation of a 160-kDa protein
23. STAT5a and STAt5b proteins have essential and nonessential, or redundant, roles in cytokine responses
24. Induction of transformed cells to terminal differentiation and the modulation of gene expression
25. Morphology of the Erythron
26. Microinjected cDNA encoding JAK2 protein-tyrosine kinase induces DNA synthesis in NIH 3T3 cells
27. Inducing differentiation of transformed cells with hybrid polar compounds: A cell cycle-dependent process