Reaction of trichloroethylene oxide with proteins and DNA: Instability of adducts and modulation of functions

Chemical Research in Toxicology

Volumn 14, Issue 1, 2001, Pages 54-61

  Cai, Hongliang ^a,b   Peter Guengerich, F ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN A; CORTICOTROPIN; DEOXYGUANOSINE; DEXTRO AMINO ACID OXIDASE; DNA; ETHYLENE OXIDE DERIVATIVE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; INSULIN; PAPAIN; TRICHLOROETHYLENE; TRICHLOROETHYLENE OXIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DNA ADDUCT; ENZYME ACTIVITY; HALF LIFE TIME; HYDROLYSIS; MASS SPECTROMETRY; MOLECULAR STABILITY;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA ADDUCTS; ENZYME INHIBITORS; EPOXY COMPOUNDS; FRUCTOSE-BISPHOSPHATE ALDOLASE; GLUCOSEPHOSPHATE DEHYDROGENASE; INSULIN; KINETICS; LYSINE; MASS SPECTROMETRY; MUSCLES; NUCLEOSIDES; OLIGONUCLEOTIDES; PROTEIN BINDING; RABBITS;

EID: 17744379566     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000185n     Document Type: Article

References (5)

1. Gist, G. L., and Burg, J. R. (1995) Trichloroethylene: A review of the literature from a health effects perspective. Toxicol. Ind. Health 11, 253-307.
2. Westrick, J. J., Mello, J. W., and Thomas, R. F. (1984) The ground water supply survey. J. Am. Water Works Assoc. 76, 52-59.
3. Toxicological Profile for Trichloroethylene (1988) Oak Ridge National Laboratory, Oak Ridge, TN.
4. Goeptar, A. R., Commandeur, J. N. M., van Ommen, B., van Bladeren, P. J., and Vermeulen, N. P. E. (1995) Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance to the mercapturic acid pathway. Chem. Res. Toxicol. 8, 3-21.
5. Robbiano, L., Mereto, E., Morando, A. M., Pastore, P., and Brambilla, G. (1998) Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics. Mutat. Res. 413, 1-6.