The effect of erythromycin and fluvoxamine on the pharmacokinetics of intravenous lidocaine

Anesthesia and Analgesia

Volumn 100, Issue 5, 2005, Pages 1352-1356

  Olkkola, Klaus T ^a,d   Isohanni, Mika H ^b,c   Hamunen, Katri ^c   Neuvonen, Pertti J ^c  

^a UNIVERSITY OF TURKU   (Finland)

^b Deaconess Hospital   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; DEETHYLLIDOCAINE; ERYTHROMYCIN; FLUVOXAMINE; FLUVOXAMINE MALEATE; LIDOCAINE; PLACEBO;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; ERYTHROMYCIN; FEMALE; FLUVOXAMINE; HUMANS; INFUSIONS, INTRAVENOUS; LIDOCAINE; MALE;

EID: 17744376204     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000148123.79437.F9     Document Type: Article

References (18)

1. Tucker GT, Mather LE. Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet 1979;4:241-78.
2. Bargetzi MJ, Aoyama T, Gonzales FJ, Meyer UA. Lignocaine metabolism in human liver microsomes by P450IIIA4. Clin Pharmacol Ther 1989;46:521-7.
3. Wang J-S, Backman JT, Taavitsainen P, et al. Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro. Pharmacol Toxicol 1999;85:201-5.
4. Wang J-S, Backman JT, Taavitsainen P, et al. Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos 2000;28:959-65.
5. Isohanni MH, Neuvonen PJ, Palkama VJ, Olkkola KT. Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine. Eur J Clin Pharmacol 1998;54:561-5.
6. Orlando R, Piccoli P, De Martin S, et al. Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function. Br J Clin Pharmacol 2003;55:86-93.
7. Orlando R, Piccoli P, De Martin S, et al. Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function. Clin Pharmacol Ther 2004;75:80-8.
8. Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT. The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine. Anesth Analg 2000;91:1207-12.
9. Lorec A-M, Bruguerolle B, Attolini L, Roucoules X. Rapid simultaneous determination of lidocaine, bupivacaine and their two main metabolites using capillary gas-liquid chromatography with nitrogen-phosphorus detector. Ther Drug Monit 1994;16:592-5.21S-8.
10. Demedts P, Wauters A, Franck F, Neels H. Simultaneous determination of lidocaine, bupivacaine and their two main metabolites using gas chromatography and a nitrogen-phosphorus detector: selection of stationary phase and chromatographic conditions. Ther Drug Monit 1996;18:208-11.
11. Laakso S, Scheinin M, Anttila M. Determination of erythromycin base and 2-acetylerythromycin in human plasma using high-performance liquid chromatography with electrochemical detection. J Chromatogr 1990;526:474-86.
12. Van der Meersch-Mougeot V, Diquet B. Sensitive one-step extraction procedure for column liquid chromatographic determination of fluvoxamine in human and rat plasma. J Chromatogr 1991;567:441-9.
13. Gibaldi M, Perrier D. Pharmacokinetics, 2nd edition. New York: Marcel Dekker, 1982.
14. Rygnestad T, Zahlsen K, Bergslien O, Dale O. Focus on mobilisation after lower abdominal surgery: a double-blind randomised comparison of epidural bupivacaine with morphine versus lidocaine with morphine for postoperative analgesia. Acta Anaesthesiol Scand 1999;43:380-7.
15. Gianelli R, Von der Groeben JO, Spicavk AP, Harrison DS. Effect of lidocaine (xylocaine) on ventricular arrhythmias in patients with coronary heart disease. N Engl J Med 1967;277:1215-9.
16. Benowitz NL, Meister W. Clinical pharmacokinetics of lignocaine. Clin Pharmacokinet 1978;3:177-201.
17. Wallace MS, Laitin S, Licht D, Yaksh TL. Concentration-effect relations for lidocaine infusions in human volunteers: effects of acute sensory thresholds and capsaicin-evoked hyperpathia. Anesthesiology 1997;86:1262-72.
18. Burney RG, Difazio CA, Peach MJ, et al. Antiarrhythmic effects of lidocaine metabolites. Am Heart J 1974;88:765-9.