Effects of a novel hepatoprotective drug, ZNC-2381, on Fas-induced hepatocellular caspase-3 activity and apoptosis in mice

Pharmacology

Volumn 62, Issue 2, 2001, Pages 80-86

  Segawa, Yoshihide ^a   Tsuzuike, Naoki ^a   Itokazu, Yoshihiko ^a   Omata, Takeshi ^a   Inoue, Naonori ^a   Nagasawa, Masaaki ^a   Nishioka, Hiroyasu ^a   Nakano, Yoshihisa ^b   Kobayashi, Tadashi ^b   Kanda, Takashi ^b  

^a ZERIA PHARMACEUTICAL CO LTD   (Japan)

^b Research Laboratories   (Japan)

Author keywords

Anti Fas antibody; Apoptosis; Caspase 3 activity; Hepatocytes; Oral drug

Indexed keywords

1 (4 AMINOPHENYL)METHYL 3 (3 NITROPHENYL) 1,3 DIHYDROIMIDAZO[4,5 B]PYRIDINE 2 ONE; ALANINE AMINOTRANSFERASE; CASPASE 3; DNA FRAGMENT; ENZYME INHIBITOR; FAS ANTIBODY; LIVER PROTECTIVE AGENT; UNCLASSIFIED DRUG; ZNC 2381;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; LIVER CELL; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NICK END LABELING; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALANINE TRANSAMINASE; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; FEMALE; HEPATOCYTES; MALE; MICE; MICE, INBRED BALB C; OLIGOPEPTIDES; PYRIDINES;

EID: 17744376169     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056075     Document Type: Article

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