Vesnarinone inhibits immune-mediated but not Fas (CD95) agonist-mediated hepatic injury

International Journal of Immunopharmacology

Volumn 19, Issue 1, 1997, Pages 49-55

  Lazarus, Douglas D ^a   Kambayashi, Taku ^a   Yato Kioka, Miki ^a   Baumann, Heinz ^b   Jacob, Chaim O ^c   Strassmann, Gideon ^a  

^a OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Apoptosis; Fas; Hepatitis; IL 6; TNF

Indexed keywords

ACUTE PHASE PROTEIN; AMINOTRANSFERASE; CONCANAVALIN A; DNA FRAGMENT; FAS ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 6; PIPERANOMETOZINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ANTIBODY;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG MECHANISM; HEPATOMA CELL; IMMUNE MEDIATED INJURY; INTRAVENOUS DRUG ADMINISTRATION; LIVER INJURY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030953796     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(96)00052-5     Document Type: Article

References (22)

1. Aderka, D., Le, J. & Vilcek, J. (1989) IL-6 inhibits lipopolysaccharide induced tumor necrosis factor production in cultured human monocytes and in mice. J. Immun., 143, 3517-3525.
2. Baumann, H. & Strassmann, G. (1993) Suramin inhibits the stimulation of acute phase plasma protein genes by IL-6 type cytokines in rat hepatoma cells. J. Immun., 151, 1456-1461.
3. Beutler, B. & Cerami, A. (1989) The biology of cachectin/TNF a primary mediator of host response. A. Rev. Immun., 7, 625-642.
4. Decker, K. & Keppler, D. (1974) Galactosamine hepatitis: key role for nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev. Physiol. Biochem. Pharmac., 71, 77-106.
5. Feldman, A. M., Bristow, M. R., Parmely, W. W., Garson, P. E., Pepine, C. E., Gilbert, E. M., Strobeck, J. E. (1993) Effect of vesnarinone on morbidity and mortality in patients with congestive heart failure. N. Engl. J. Med., 329, 236-241.
6. Gantner, F., Leist, M., Lohse, A. W., Germann, P. G. & Tiegs, G. (1995) Concanavalin A induced T cell mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology, 21, 190-198.
7. Hirano, T., Akira, S., Taga, J. & Kishimoto, T. (1990) Biological and clinical aspects of interleukin 6. Immun. Today, 11, 443-449.
8. Kambayashi, T., Alexander, H. R., Fong, M. & Strassmann, G. (1995) Potential involvement of IL-10 in suppressing tumor associated macrophages. J. Immun., 154, 3383-3390.
9. Kambayashi, T., Mazurek, M., Jacob, C.O., Wei, N., Fong, M. & Strassmann G. (1996). Vesnarinone is a selective inhibitor of macrophage TNFα release. Int. J. Immunopharmacol., 18, 371-378.
10. Kohase, M., Henriksen-DeStefano, D., May, L. T., Vilcek, J. & Sehgal, P. (1986) Induction of beta2 interferon by tumor necrosis factor: a hemostatic mechanism in the control of cell proliferation. Cell, 45, 658-677.
11. Keppler, D., Lesch, R., Reutter, W. & Decker, K. (1968) Experimental hepatitis induced by D galactosamine. Exp. molec. Path., 9, 279-290.
12. Leist, M., Gantner, F., Bohlinger, I., Germann, P. G. & Wendel, A. (1995) Tumor necrosis factor induced apoptosis precedes liver failure in experimental murine shock models. Am. J. Path., 146, 1220-1234.
13. Leist, M., Gantner, F., Kunstle, G., Bohlinger, I., Teigs, G., Bluethman, H. & Wendel, A. (1996) The 55-kD tumor necrosis factor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. Molec. Med., 2, 109-124.
14. Maruyama, I., Maruyama, Y., Nakajima, T., Kitajima, I., Osame, K., Mzhao, J. & Chen, I. S. (1993) Vesnarinone inhibits production of HIV-1 in cultured cells. Biochem. biophys. Res. Commun., 195, 1264-1271.
15. Matsumori, A., Shioi, T., Yamada, T., Matsui, S. & Sasayama, S. (1994) Vesnarinone: a new inotropic agent inhibits cytokine production by stimulated blood from patients with heart failure. Circulation, 89, 955-958.
16. Mizuhara, H., O'Neil, E., Seki, N., Ogawa, T., Kusunoki, C., Otsuka, K. & Satoh, S. (1994) A T cell activation associated hepatic injury; mediation by tumor necrosis factor and protection by interleukin 6. J. exp. Med., 179, 1529-1537.
17. Osagawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, M., Kasugai, T., Kitamura, Y. & Itoh, N. (1993) Lethal effects of anti-Fas antibody in mice. Nature, 364, 806-809.
18. Recknagel, R. O., Glende, E. A., Dolak, J. A. & Walker, R. L. (1989) Mechanisms of carbon tetrachloride hepatotoxicity. Pharmac. Ther., 43, 139-154.
19. Strassmann, G., Koota, P., Finkelman, F., Fong, M. & Kambayashi, T. (1994) Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J. exp. Med., 180, 2365-2370.
20. Tiegs, G., Hentschel, J. & Wendel, A. A. (1992) T cell dependent experimental liver injury in mice inducible by concanavalin A. J. clin. Invest., 90, 196-203.
21. Wermers, G. W., Band, H. & Yunis E. J. (1988). Role of the HLA system in antigen recognition and disease. In The Liver: Biology and Pathobiology (eds Arias, I. M., Jakoby, W. B., Popper, H., Sachcter, D. & Shafritz, D. A.), pp. 885-895. Raven Press, New York.
22. Vassali, P. (1992) The pathophysiology of tumor necrosis factor. A. Rev. Immun., 10, 411-434.