The human leukocyte antigen HLA DRB3*0202/DQA1*0501 haplotype is associated with Graves' disease in African Americans

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 4, 2000, Pages 1545-1549

  Chen, Qiao Yi ^a,b   Nadell, David ^a   Zhang, Xian Yang ^a   Kukreja, Anjli ^a,b   Huang, Yao Jin ^a   Wise, Jonathan ^d   Svec, Frank ^c   Richards, Robert ^e   Friday, Karen E ^e   Vargas, Alfonso ^a,b   Gomez, Ricardo ^a,b   Chalew, Stuart ^a,b   Lan, Michael S ^a,b   Tomer, Yaron ^f   Maclaren, Noel K ^a,b,g  

^a Research Institute for Children   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LSUM   (United States)

^d HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^e TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^g Research Institute for Children   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA ANTIGEN;

ADULT; ALLELE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GRAVES DISEASE; HAPLOTYPE; HUMAN; HUMAN CELL; MALE; NEGRO; PRIORITY JOURNAL;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; FEMALE; GENE FREQUENCY; GRAVES DISEASE; HAPLOTYPES; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; IMMUNOCONJUGATES; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 17744366587     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.4.1545     Document Type: Article

References (25)

1. Immunology of human thyroid disease
2. HLA-DRB3 gene alleles in Caucasian patients with Graves' disease
3. Human histocompatibility leukocyte antigen-DQA1*0501 allele associated with genetic susceptibility to Graves' disease in a Caucasian population
4. Rapid and simple subtyping of the HLA-DRB3 gene in Graves' disease by using temperature-gradient gel electrophoresis
5. HLA class II associations in juvenile Graves' disease: Indication of a strong protective role of the DRB1*0701,DQA1*0201 haplotype
6. HLA-DRB1*08, DRB1*03/DRB3*0101 and DRB3*0202 are susceptibility genes for Graves' disease in N. American Caucasians, while DRB1*07 is protective
7. HLA-DQ3 is associated with Graves' disease in African-Americans
8. HLA class II associations in African-American female patients with Graves' disease
9. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population
10. A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism
11. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
12. The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus
13. No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies
14. Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta-cell autoimmunity
15. HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours
16. HLA class I and II antigens in South African blacks with Graves' disease
17. HLA immunogenetic heterogeneity In black American patients with Graves' disease
18. Multivariate analysis of HLA loci in conjunction with a thyrotropin receptor codon 52 polymorphism in conferring risk of Graves' disease
19. Analysis of HLA DQ alpha allele and genotype frequencies in populations from Florida
20. African-American HLA class II allele and haplotype diversity
21. Allele and haplotype frequencies for HLA and complement loci in various ethnic groups
22. Association of the HLA-DQA1*0501 allele in multiple racial groups with juvenile dermatomyositis
23. Strong association between HLA-DQA1*0501 and Graves' disease in a male Caucasian population
24. Association of HLA-DQA1*0501 with Graves' disease in English Caucasian men and women
25. Lack of an independent association between the human leukocyte antigen allele DQA1*0501 and Graves' disease