Development of a novel system for producing ajmalicine and serpentine using direct culture of leaves in Catharanthus roseus intact plant

Journal of Bioscience and Bioengineering

Volumn 99, Issue 3, 2005, Pages 208-215

  Iwase, Akira ^a   Aoyagi, Hideki ^a   Ohme Takagi, Masaru ^b   Tanaka, Hideo ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Biosynthesis; Catharanthus roseus; Cell culture; Secondary metabolite; Terpenoid indole alkaloid

Indexed keywords

CELL CULTURE; ENZYMES; GENES; GLUCOSE; IRRADIATION; PLANTS (BOTANY); SERPENTINE;

AJMALICINE; GENE EXPRESSIONS; LIGHT IRRADIATION; RT-PCR ANALYSIS;

METABOLITES;

AJMALICINE; DNA; INDOLE ALKALOID; PLANT EXTRACT; RNA; SERPENTINE; TERPENOID;

ARTICLE; BIOSYNTHESIS; CATHARANTHUS ROSEUS; CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT LEAF; REAL TIME POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY;

CATHARANTHUS ROSEUS;

EID: 17644424925     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1263/jbb.99.208     Document Type: Article

References (30)

1. Bourgaud, F., Gravot, A., Milesi, S., and Gontier, E.: Production of plant secondary metabolites: a historical perspective. Plant Sci., 161, 839-851 (2001).
2. Fujita, Y., Kara, Y., Ogino, T., and Suga, C.: Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon. Plant Cell Rep., 1, 59-60 (1981).
3. Honda, Y., Inaoka, H., Takei, A., Sugimura, Y., and Otsuji, K.: Extracellular polysaccharides produced by Tuberose callus. Phytochemistry, 41, 1517-1521 (1996).
4. Hong, J. J.: Plant cell culture for production of paclitaxel and other taxanes. J. Biosci. Bioeng., 94, 591-599 (2002).
5. DiCosmo, F. and Misawa, M.: Plant cell and tissue culture: alternatives for metabolite production. Biotechnol. Adv., 13, 425-453 (1995).
6. Deus-Neumann, B. and Zenk, M. H.: Instability of indole alkaloid production in Catharanthus roseus cell suspension cultures. Planta Med., 50, 427-431 (1984).
7. Phillips, R. L., Kaeppler, S. M., and Olhoft, P.: Genetic instability of plant tissue cultures: breakdown of normal controls. Proc. Natl. Acad. Sci. USA, 91, 5222-5226 (1994).
8. Kaeppler, S. M. and Phillips, R. L.: Tissue culture-induced DNA methylation variation in maize. Proc. Natl. Acad. Sci. USA, 90, 8773-8776 (1993).
9. Lambe, P., Dinant, M., and Matagne, R. F.: Differential long-term expression and methylation of the hygromycin phosphotransferase (hph) and beta-glucuronidase (GUS) genes in transgenic pearl-millet (Pennisetum glaucum) callus. Plant Sci., 108, 51-62 (1995).
10. Whitmer, S., Canel, C., van der Heijden, R., and Verpoorte, R.: Long-term instability of alkaloid production by stably transformed cell lines of Catharanthus roseus. Plant Cell Tissue Organ Cult., 74, 73-80 (2003).
11. Hashimoto, T. and Yamada, Y.: Alkaloid biogenesis: molecular aspects. Annu. Rev. Plant Physiol. Plant Mol. Biol., 45, 257-285 (1994).
12. St-Pierre, B., Vazquez-Flota, F. A., and De Luca, V.: Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate. Plant Cell, 11, 887-900 (1999).
13. van der Heijden, R., Jacobs, D.I., Snoeijer, W., Hallared, D., and Verpoorte, R.: The Catharanthus alkaloids: pharmacognosy and biotechnology. Curr. Med. Chem., 11, 607-628 (2004).
14. Murashige, T. and Skoog, F.: A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant., 15, 473-497 (1962).
15. Yamada, Y., Kobayashi, S., Watanabe, K., and Hayashi, U.: Production of horseradish peroxidase by plant cell culture. J. Chem. Technol. Biotechnol., 38, 31-39 (1987).
16. Aoyagi, H., Sakamoto, Y., Asada, M., and Tanaka, H.: Indole alkaloids production by Catharanthus roseus protoplasts with artificial cell walls containing of guluronic acid rich alginate gel. J. Ferment. Bioeng., 85, 306-311 (1998).
17. Jung, K. H., Kwak, S. S., Kim, S. W., Lee, H., Choi, C. Y., and Liu, J. R.: Improvement of the catharanthine productivity in hairy root cultures of Catharanthus roseus by using monosaccharides as a carbon source. Biotechnol. Lett., 14, 695-700 (1992).
18. Farnsworth, N. R., Blomster, R. N., Damratoski, D., Meer, W. A., and Cammarato, L. V.: Studies on Catharanthus alkaloids. VI. Evaluation by means of thin-layer chromatography and ceric ammonium sulfate spray reagent. Lloydia, 27, 302-314 (1964).
19. Morris, P., Scragg, A.H., Smart, N.J., and Stafford, A.: T.l.c. separation of Catharanthus alkaloids, p. 141-143. In Dixon, R.A. (ed.), Plant cell culture: a practical approach. IRL Press, Eynsham (1985).
20. Hiratsu, K., Matsui, K., Koyama, T., and Ohme-Takagi, M.: Dominant repression of target genes by chimeric repressors that include the EAR motif, a repression domain, in Arabidopsis. Plant. J., 34, 733-739 (2003).
21. Mohr, H. and Schopfer, P.: Concept of water potential in the water relations of cells, p. 45-51. In Mohr, H. and Schopfer, P. (ed.), Plant physiology. Springer-Verlag, Berlin, Heidelberg, New York (1994).
22. Blom, T. J. M., Sierra, M., Vanvliet, T. B., Franke-van Dijk, M. E. I., De Koning, P., van Iren, F., Verpoorte, R., and Libbenga, K. R.: Uptake and accumulation of ajmalicine into isolated vacuoles of cultured cell of Catharanthus roseus (L.) G Don. and its conversion into serpentine. Planta, 183, 170-177 (1991).
23. Drapeau, D., Blanch, H. W., and Wilke, C. R.: Economic assessment of plant cell culture for the production of ajmalicine. Biotechnol. Bioeng., 30, 946-953 (1987).
24. Fukuda, H. and Komiamine, A.: Establishment of an experimental system for the study of trachery element differentiation from single cells isolated from the mesophyll of Zinnia elegans. Plant. Physiol., 65, 57-60 (1980).
25. Moreno, P. R. H., van der Heijden, R., and Verpoorte, R.: Cell and tissue cultures of Catharanthus roseus (L.) G Don: a literature survey II. Updating from 1988 to 1993. Plant Cell Tissue Organ Cult., 42, 1-25 (1995).
26. Asai, I., Yoshihira, K., Omoto, T., Sakui, N., and Shimomura, K.: Growth and monoterpene production in shoot culture and regenerates of Mentha arvensis. Plant Tissue Cult. Lett., 11, 218-225 (1994).
27. Morris, P.: Regulation of product synthesis in cell cultures of Catharanthus roseus. III. Alkaloid metabolism in cultured leaf tissue and primary callus. Planta Med., 52, 127-132 (1986).
28. Balsevich, J., De Luca, V., and Kurz, W. G. W.: Altered alkaloid pattern in dark grown seedlings of Catharanthus roseus. The isolation and characterization of 4-desacetoxy-vindoline: a novel indole alkaloid and proposed precursor of vindoline. Heterocycles, 24, 2415-2421 (1986).
29. van der Heijden, R., Verpoorte, R., and Ten Hoopen, H. J. G.: Cell and tissue cultures of Catharanthus roseus (L.) G. Don: a literature survey. Plant Cell Tissue Organ Cult., 18, 231-280 (1989).
30. Asada, M. and Shuler, M. L.: Stimulation of ajmalicine production and excretion from Catharanthus roseus: effects of adsorption in situ, elicitors and alginate immobilization. Appl. Microbiol. Biotechnol., 30, 475-481 (1989).