Biomarkers of alcohol consumption in patients classified according to the degree of liver disease severity

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 65, Issue 2, 2005, Pages 141-151

  Anttila, P ^a   Jarvi K ^a   Latvala, J ^a   Romppanen, J ^c   Punnonen, K ^c   Niemelä, Onni ^a,b  

^a EP Central Hospital Laboratory   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Alcohol markers; Ethanol; Fibrogenesis; Sialic acid; Transferrin

Indexed keywords

ALCOHOL; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CARBOHYDRATE DEFICIENT TRANSFERRIN; GAMMA GLUTAMYLTRANSFERASE; SIALIC ACID;

ABSTINENCE; ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; DRINKING BEHAVIOR; FEMALE; FIBROGENESIS; HUMAN; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; PRIORITY JOURNAL; ROC CURVE; TRANSFERRIN BLOOD LEVEL; VOLUNTEER;

ADULT; ALCOHOLISM; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CLINICAL LABORATORY TECHNIQUES; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; LIVER CIRRHOSIS, ALCOHOLIC; MALE; MIDDLE AGED; N-ACETYLNEURAMINIC ACID; PEPTIDE FRAGMENTS; PROCOLLAGEN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TRANSFERRIN;

EID: 17644400148     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365510510013532     Document Type: Article

References (28)

1. Rosman AS, Lieber CS. Diagnostic utility of laboratory tests in alcoholic liver disease. Clin Chem 1994;40:1641-51.
2. Niemelä O. Serum diagnosis of ALD and markers of ethanol intake. In Sherman D, Preedy V, Watson R, editors. Ethanol and the liver: mechanisms and management. London and New York: Taylor and Francis; 2002. pp 411-49.
3. Anttila P, Järvi K, Latvala J, Blake JE, Niemelä O. Diagnostic characteristics of different carbohydrate-deficient transferrin methods in the detection of problem drinking: effects of liver disease and alcohol consumption. Alcohol Alcohol 2003;38:415-20.
4. Arndt T. Carbohydrate-deficient transferrin as a marker of chronic alcohol abuse: a critical review of preanalysis, analysis, and interpretation. Clin Chem 2001;47:13-27.
5. Helander A. Multicentre validation study of instrument applications for %CDT, an immunoassay for quantification of carbohydrate-deficient transferrin in serum. Alcohol Alcohol 2002;37:209-12.
6. Scouller K, Conigrave KM, Macaskill P, Irwig L, Whitfield JB. Should we use carbohydrate-deficient transferrin instead of gamma-glutamyltransferase for detecting problem drinkers? A systematic review and metaanalysis. Clin Chem 2000;46:1894-902.
7. Sillanaukee P, Strid N, Allen JP, Litten RZ. Possible reasons why heavy drinking increases carbohydrate-deficient transferrin. Alcohol Clin Exp Res 2001;25:34-40.
8. Allen JP, Litten RZ, Anton RF, Cross GM. Carbohydrate-deficient transferrin as a measure of immoderate drinking: remaining issues. Alcohol Clin Exp Res 1994;18:799-812.
9. Helander A, Tabakoff B. Biochemical markers of alcohol use and abuse: experiences from the Pilot Study of the WHO/ISBRA Collaborative Project on state and trait markers of alcohol. International Society for Biomedical Research on Alcoholism. Alcohol Alcohol 1997;32:133-44.
10. Stibler H. Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. Clin Chem 1991;37:2029-37.
11. Helander A, Eriksson G, Stibler H, Jeppsson JO. Interference of transferrin isoform types with carbohydrate-deficient transferrin quantification in the identification of alcohol abuse. Clin Chem 2001;47:1225-33.
12. Pönniö M, Alho H, Heinälä P, Nikkari ST, Sillanaukee P. Serum and saliva levels of sialic acid are elevated in alcoholics. Alcohol Clin Exp Res 1999;23:1060-4.
13. Romppanen J, Punnonen K, Anttila P, Jakobsson T, Blake J, Niemelä O. Serum sialic acid as a marker of alcohol consumption: effect of liver disease and heavy drinking. Alcohol Clin Exp Res 2002;26:1234-8.
14. Sillanaukee P, Pönniö M, Seppä K. Sialic acid: new potential marker of alcohol abuse. Alcohol Clin Exp Res 1999;23:1039-43.
15. Blake J, Orrego H. Monitoring treatment of alcoholic liver disease: evaluation of various severity indices. Clin Chem 1991;37:5-13.
16. Arndt T, Hackler R, Kleine TO, Gressner AM. Validation by isoelectric focusing of the anion-exchange isotransferrin fractionation step involved in determination of carbohydrate-deficient transferrin by the CDTect assay. Clin Chem 1998;44:27-34.
17. Anton RF, Dominick C, Bigelow M, Westby C. Comparison of Bio-Rad %CDT TIA and CDTect as laboratory markers of heavy alcohol use and their relationships with gamma-glutamyltransferase. Clin Chem 2001;47:1769-75.
18. Keating J, Cheung C, Peters TJ, Sherwood RA. Carbohydrate deficient transferrin in the assessment of alcohol misuse: absolute or relative measurements? A comparison of two methods with regard to total transferrin concentration. Clin Chim Acta 1998;272:159-69.
19. Pönniö M, Sillanaukee P, Franck J. Serum sialic acid levels are increased during relapse to alcohol drinking: a pilot study. Alcohol Clin Exp Res 2002;26:1365-7.
20. Crook MA, Couchman S, Tutt P. Plasma fibrinogen and its relationship to plasma sialic acid in non-insulin-dependent diabetes mellitus. Blood Coagul Fibrinolysis 1996;7:586-9.
21. Romppanen J, Eskelinen M, Tikanoja S, Mononen I. Total and lipid-bound serum sialic acid in benign and malignant breast disease. Anticancer Res 1997;17:1249-53.
22. Romppanen J, Petäjä J, Heikinheimo M, Mononen I. Total and lipid-bound serum sialic acid in children with malignancy or infections. Anticancer Res 1998;18:2793-7.
23. Niemelä O, Risteli J, Blake JE, Risteli L, Compton KV, Orrego H. Markers of fibrogenesis and basement membrane formation in alcoholic liver disease. Relation to severity, presence of hepatitis, and alcohol intake. Gastroenterology 1990;98:1612-9.
24. Nojgaard C, Johansen JS, Cristensen E, Skovgaard LT, Prive PA, Becker U, EMALD group. Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease. J Hepatol 2003;39:179-86.
25. Anttila P, Järvi K, Latvala J, Niemelä O. Method-dependent characteristics of carbohydrate-deficient transferrin measurements in the follow-up of alcoholics. Alcohol Alcohol 2004;39:59-63.
26. Löf K, Seppä K, Itälä L, Koivula T, Turpeinen U, Sillanaukee P. Carbohydrate-deficient transferrin as an alcohol marker among female heavy drinkers: a population based study. Alcohol Clin Exp Res 1994;18:889-94.
27. Helander A, Carlsson S. Carbohydrate-deficient transferrin and gamma-glutamyl transferase levels during disulfiram therapy. Alcohol Clin Exp Res 1996;20:1202-5.
28. Lesch OM, Walter H, Antal J, Kanitz RD, Kovacz A, Leitner A, et al. Alcohol dependence: is carbohydrate-deficient transferrin a marker for alcohol intake? Alcohol Alcohol ;31:257-64.