Diagnostic characteristics of different carbohydrate-deficient transferrin methods in the detection of problem drinking: Effects of liver disease and alcohol consumption

Alcohol and Alcoholism

Volumn 38, Issue 5, 2003, Pages 415-420

  Anttila, Petra ^a   Järvi, Kimmo ^a   Latvala, Jaana ^a   Blake, Joan E ^c   Niemelä, Onni ^a,b  

^a EP Central Hospital Laboratory   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CARBOHYDRATE DEFICIENT TRANSFERRIN; ISOPROTEIN;

ADULT; ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ALCOHOLISM; ARTICLE; CLINICAL FEATURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRINKING BEHAVIOR; FEMALE; HUMAN; INTERMETHOD COMPARISON; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SAMPLING; SELF REPORT; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

ADULT; AGED; ALCOHOL DRINKING; ALCOHOLISM; ANALYSIS OF VARIANCE; FEMALE; HUMANS; LIVER DISEASES, ALCOHOLIC; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC; TRANSFERRIN;

EID: 0042830358     PISSN: 07350414     EISSN: None     Source Type: Journal    
DOI: 10.1093/alcalc/agg102     Document Type: Article

References (33)

1. Allen, J. P., Litten, R. Z., Anton, R. F. and Cross, G. M. (1994) Carbohydrate-deficient transferrin is a measure of immoderate drinking: remaining issues. Alcoholism: Clinical and Experimental Research 18, 799-812.
2. Anton, R. F. and Moak, D. H. (1994) Carbohydrate-deficient transferrin and γ-glutamyltransferase as markers of heavy alcohol consumption: gender differences. Alcoholism: Clinical and Experimental Research 18, 747-754.
3. Anton, R. F., Dominick, C., Bigelow, M. and Westby, C. (2001) Comparison of Bio-Rad %CDT TIA and CDTect as laboratory markers of heavy alcohol use and their relationships with γ-glutamyltransferase. Clinical Chemistry 47, 1769-1775.
4. Arndt, T. (2001) Carbohydrate-deficient transferrin as a marker of chronic alcohol misuse: a critical review of preanalysis, analysis, and interpretation. Clinical Chemistry 47, 13-27.
5. Arndt, T. and Kropf, J. (2002) Alcohol misuse and carbohydrate deficient transferrin analysis: are screening and confirmatory analysis required? Clinical Chemistry 48, 2072-2074.
6. Arndt, T., Hackler, R., Kleine, T. O. and Gressner, A. M. (1998) Validation of isoelectric focusing of the anion-exchange isotransferrin fractionation step involved in determination of carbohydrate-deficient transferrin by the CDTect assay. Clinical Chemistry 44, 27-34.
7. Arndt, T., Korzec, A., Bar, M. and Kropf, J. (2002) Further arguments against including trisialo-Fe2-transferrin in carbohydrate-deficient transferrin (CDT): a study on male alcoholics and hazardous drinkers. Medical Science Monitoring 8(6), 411-418.
8. Bean, P., Liegmann, K., Lovli, T., Westby, C. and Sundrehagen, E. (1997) Semiautomated procedures for evaluation of carbohydrate-deficient transferrin in the diagnosis of alcohol misuse. Clinical Chemistry 43, 983-989.
9. Blake, J. and Orrego, H. (1991) Monitoring treatment of alcoholic liver disease: evaluation of various severity indices. Clinical Chemistry 37, 5-13.
10. Conigrave, K. M, Degenhardt, L. J., Whitfield, J. B., Saunders, J. B., Helander, A. and Tabakoff, B. (2002) CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative project. Alcoholism: Clinical and Experimental Research 26, 332-339.
11. De Feo, T. M., Fargion, S., Duca, L., Mattioli, M., Cappellini, M. D., Sampietro, M., Cesana, B. M. and Fiorelli, G. (1999) Carbohydrate-deficient transferrin, a sensitive marker of chronic alcohol misuse, is highly influenced by body iron. Hepatology 29, 658-663.
12. DiMartini, A., Day, N., Lane, T., Beisler, A. T., Dew, M. A. and Anton, R. (2001) Carbohydrate deficient transferrin in abstaining patients with end-stage liver disease. Alcoholism: Clinical and Experimental Research 25, 1729-1733.
13. Helander, A. (1999) Absolute or relative measurement of carbohydrate-deficient transferrin in serum? Experiences with three immunological assays. Clinical Chemistry 45, 131-135.
14. Helander, A. (2002) Multicentre validation study of instrument applications for %CDT, an immunoassay for quantification of carbohydrate-deficient transferrin in serum. Alcohol and Alcoholism 37, 209-212.
15. Helander, A., Eriksson, G., Stibler, H. and Jeppsson, J. O. (2001a) Interference of transferrin isoform types with carbohydrate-deficient transferrin quantification in the identification of alcohol misuse. Clinical Chemistry 47, 1225-1233.
16. Helander, A., Fors, M. and Zakrisson, B. (2001b) Study of Axis-Shield new %CDT immunoassay for quantitation of carbohydrate-deficient transferrin (CDT) in serum. Alcohol and Alcoholism 36, 406-412.
17. Legros, F. J., Nuyens, V., Minet, E., Emonts, P., Boudjeltia, K. Z., Courbe, A., Roulle, J. L., Colicis, J., de L'Escaille, F. and Henry, J. P. (2002) Carbohydrate-deficient transferrin isoforms measured by capillary zone electrophoresis for detection of alcohol misuse. Clinical Chemistry 48(12), 2177-2186.
18. Legros, F. J., Nuyens, V., Baudoux, M., Zouaoui Boudjeltia, K., Roulle, J. L., Colicis, J., Cantraine, F. and Henry, J. P. (2003) Use of capillary zone electrophoresis for differentiating excessive from moderate alcohol consumption. Clinical Chemistry 49(3), 440-449.
19. Lof, K., Seppä, K., Itälä, L., Koivula, T., Turpeinen, U. and Sillanaukee, P. (1994) Carbohydrate-deficient transferrin (CDT) as an alcohol marker among female heavy drinkers: a population-based study. Alcoholism: Clinical and Experimental Research 18, 889-894.
20. Niemelä, O., Sorvajärvi, K., Blake, J. E. and Israel, Y. (1995) Carbohydrate-deficient transferrin as a marker of alcohol misuse: relationship to alcohol consumption, severity of liver disease, and fibrogenesis. Alcoholism: Clinical and Experimental Research 19, 1203-1208.
21. Nyström, M., Peräsalo, J. and Salaspuro, M. (1992) Carbohydrate-deficient transferrin (CDT) in serum as a possible indicator of heavy drinking in young university students. Alcoholism: Clinical and Experimental Research 16, 93-97.
22. Potter, B. J., Chapman, R. W. G., Nunes, R. M., Sorrentino, D. and Sherlock, S. (1985) Transferrin metabolism in alcoholic liver disease. Hepatology 5, 714-721.
23. Reif, A., Keller, H., Schneider, M., Kamolz, S., Schmidtke, A. and Fallgatter, A. J. (2001) Carbohydrate-deficient transferrin is elevated in catabolic female patients. Alcohol and Alcoholism 36, 603-607.
24. Salaspuro, M. (1999) Carbohydrate-deficient transferrin as compared to other markers of alcoholism: a systematic review. Alcohol 19, 261-271.
25. Scouller, K., Conigrave, K. M., Macaskill, P., Irwing, L. and Whitfield, J. B. (2000) Should we use carbohydrate-deficient transferrin instead of gammaglutamyltransferase for detecting problem drinkers? A systematic review and meta-analysis. Clinical Chemistry 46, 1894-1902.
26. Sillanaukee, P., Strid, N., Allen, J. P. and Litten, R. Z. (2001) Possible reasons why heavy drinking increases carbohydrate-deficient transferrin. Alcoholism: Clinical and Experimental Research 25, 34-40.
27. Sorvajärvi, K., Blake, J. E., Israel, Y. and Niemelä, O. (1996) Sensitivity and specificity of carbohydrate-deficient transferrin as a marker of alcohol misuse are significantly influenced by alterations in serum transferrin: comparison of two methods. Alcoholism: Clinical and Experimental Research 20, 449-454.
28. Stibler, H. (1991) Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. Clinical Chemistry 37, 2029-2037.
29. Tagliaro, F., Bortolotti, F., Dorizzi, R. M. and Marigo, M. (2002) Caveates in carbohydrate-deficient transferrin determination. Clinical Chemistry 48, 208-209.
30. Tsutsumi, M., Wang, J. S. and Takada, A. (1994) Microheterogeneity of serum glycoproteins in alcoholics: is desialo-transferrin the marker of chronic alcohol drinking or alcoholic liver injury? Alcoholism: Clinical and Experimental Research 18, 392-397.
31. Viitala, K., Lähdesmäki, K. and Niemelä, O. (1998) Comparison of the Axis %CDT TIA and the CDTect method as laboratory tests of alcohol misuse. Clinical Chemistry 44, 1209-1215.
32. Whitfield, J. B. (2002). Transferrin isoform analysis for the diagnosis and management of hazardous or dependent drinking. Clinical Chemistry 48, 2095-2096.
33. Whitfield, J. B., Zhu, G., Heath, A. C., Powell, L. W. and Martin, N. G. (2001) Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcoholism: Clinical and Experimental Research 25, 1037-1045.