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Volumn 45, Issue 5, 2005, Pages 529-537

Kinetics and dynamics of intravenous adinazolam, N-desmethyl adinazolam, and alprazolam in healthy volunteers

Author keywords

Adinazolam; Alprazolam; Digit Symbol Substitution Test; Electroencephalography; N desmethyl adinazolam; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ADINAZOLAM; ALPRAZOLAM; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; NORADINAZOLAM; SEDATIVE AGENT; UNCLASSIFIED DRUG;

EID: 17644395684     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/0091270004269105     Document Type: Article
Times cited : (28)

References (41)
  • 1
    • 0023248764 scopus 로고
    • Adinazolam - A new antidepressant: Findings of a placebo-controlled, double-blind study in outpatients with major depression
    • Dunner D, Myers J, Khan A, Avery D, Ishiki D, Pyke R. Adinazolam - a new antidepressant: findings of a placebo-controlled, double-blind study in outpatients with major depression. J Clin Psychopharmacol. 1987;7:170-172.
    • (1987) J Clin Psychopharmacol , vol.7 , pp. 170-172
    • Dunner, D.1    Myers, J.2    Khan, A.3    Avery, D.4    Ishiki, D.5    Pyke, R.6
  • 2
    • 0022571922 scopus 로고
    • Adinazolam, a new triazolobenzodiazepine, and imipramine in the treatment of major depressive disorder
    • Amsterdam JD, Kaplan M, Potter L, Bloom L, Rickels K. Adinazolam, a new triazolobenzodiazepine, and imipramine in the treatment of major depressive disorder. Psychopharmacology (Berl). 1986;88:484-488.
    • (1986) Psychopharmacology (Berl) , vol.88 , pp. 484-488
    • Amsterdam, J.D.1    Kaplan, M.2    Potter, L.3    Bloom, L.4    Rickels, K.5
  • 3
    • 0028144965 scopus 로고
    • Adinazolam sustained-release treatment of panic disorder: A double-blind study
    • Davidson JR, Beitman B, Greist JH, et al. Adinazolam sustained-release treatment of panic disorder: a double-blind study. J Clin Psychopharmacol. 1994;14:255-263.
    • (1994) J Clin Psychopharmacol , vol.14 , pp. 255-263
    • Davidson, J.R.1    Beitman, B.2    Greist, J.H.3
  • 5
    • 0025859140 scopus 로고
    • Extent and variability of the first-pass elimination of adinazolam mesylate in healthy male volunteers
    • Fleishaker JC, Friedman H, Pollock SR. Extent and variability of the first-pass elimination of adinazolam mesylate in healthy male volunteers. Pharm Res. 1991;8:162-167.
    • (1991) Pharm Res , vol.8 , pp. 162-167
    • Fleishaker, J.C.1    Friedman, H.2    Pollock, S.R.3
  • 6
    • 0024389549 scopus 로고
    • Multiple-dose pharmacokinetics and pharmacodynamics of adinazolam in elderly subjects
    • Fleishaker JC, Phillips JP, Smith TC, Smith RB. Multiple-dose pharmacokinetics and pharmacodynamics of adinazolam in elderly subjects. Pharm Res. 1989;6:379-386.
    • (1989) Pharm Res , vol.6 , pp. 379-386
    • Fleishaker, J.C.1    Phillips, J.P.2    Smith, T.C.3    Smith, R.B.4
  • 7
    • 0021250760 scopus 로고
    • Determination of biological activity of adinazolam and its metabolites
    • Sethy VH, Collins RJ, Daniels EG. Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984;36:546-548.
    • (1984) J Pharm Pharmacol , vol.36 , pp. 546-548
    • Sethy, V.H.1    Collins, R.J.2    Daniels, E.G.3
  • 8
    • 0025696490 scopus 로고
    • Clinical pharmacology of adinazolam and N-desmethyladinazolam mesylate after single oral doses of each compound in healthy volunteers
    • Fleishaker JC, Friedman H, Pollock SR, Smith TC. Clinical pharmacology of adinazolam and N-desmethyladinazolam mesylate after single oral doses of each compound in healthy volunteers. Clin Pharmacol Ther. 1990;48:652-664.
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 652-664
    • Fleishaker, J.C.1    Friedman, H.2    Pollock, S.R.3    Smith, T.C.4
  • 9
    • 0026569770 scopus 로고
    • Clinical pharmacology of adinazolam and N-desmethyladinazolam mesylate following single intravenous infusions of each compound in health volunteers
    • Fleishaker JC, Hulst LK, Smith TC, Friedman H. Clinical pharmacology of adinazolam and N-desmethyladinazolam mesylate following single intravenous infusions of each compound in health volunteers. Eur J Clin Pharmacol. 1992;42:287-294.
    • (1992) Eur J Clin Pharmacol , vol.42 , pp. 287-294
    • Fleishaker, J.C.1    Hulst, L.K.2    Smith, T.C.3    Friedman, H.4
  • 10
    • 0026582918 scopus 로고
    • Separation of the pharmacokinetic/pharmacodynamic properties of adinazolam mesylate and N-desmethyladinazolam mesylate following oral and IV administration of each compound in man
    • Fleishaker JC, Smith TC, Friedman HL, Hulst LK. Separation of the pharmacokinetic/pharmacodynamic properties of adinazolam mesylate and N-desmethyladinazolam mesylate following oral and IV administration of each compound in man. Drug Invest. 1992;4:155-165.
    • (1992) Drug Invest , vol.4 , pp. 155-165
    • Fleishaker, J.C.1    Smith, T.C.2    Friedman, H.L.3    Hulst, L.K.4
  • 11
    • 0026440045 scopus 로고
    • Pharmacokinetics and pharmacodynamics of adinazolam and N-desmethyladinazolam after oral and intravenous dosing in healthy young and elderly volunteers
    • Fleishaker JC, Hulst LK, Ekernas SA, Grahnen A. Pharmacokinetics and pharmacodynamics of adinazolam and N-desmethyladinazolam after oral and intravenous dosing in healthy young and elderly volunteers. J Clin Psychopharmacol. 1992;12:403-414.
    • (1992) J Clin Psychopharmacol , vol.12 , pp. 403-414
    • Fleishaker, J.C.1    Hulst, L.K.2    Ekernas, S.A.3    Grahnen, A.4
  • 12
    • 0027253453 scopus 로고
    • Psychomotor and memory effects of two adinazolam formulations assessed by a computerized neuropsychological test battery
    • Fleishaker JC, Sisson TA, Sramek JJ, Conrad J, Veroff AE, Cutler NR. Psychomotor and memory effects of two adinazolam formulations assessed by a computerized neuropsychological test battery. J Clin Pharmacol. 1993;33:463-469.
    • (1993) J Clin Pharmacol , vol.33 , pp. 463-469
    • Fleishaker, J.C.1    Sisson, T.A.2    Sramek, J.J.3    Conrad, J.4    Veroff, A.E.5    Cutler, N.R.6
  • 13
    • 0030069622 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships for benzodiazepines
    • Laurijssens BE, Greenblatt DJ. Pharmacokinetic-pharmacodynamic relationships for benzodiazepines. Clin Pharmacokinet 1996;30:52-76.
    • (1996) Clin Pharmacokinet , vol.30 , pp. 52-76
    • Laurijssens, B.E.1    Greenblatt, D.J.2
  • 14
    • 0024336476 scopus 로고
    • Kinetic and dynamic study of intravenous lorazepam: Comparison with intravenous diazepam
    • Greenblatt DJ, Ehrenberg BL, Gunderman J, et al. Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam. J Pharmacol Exp Ther. 1989;250:134-140.
    • (1989) J Pharmacol Exp Ther , vol.250 , pp. 134-140
    • Greenblatt, D.J.1    Ehrenberg, B.L.2    Gunderman, J.3
  • 15
    • 0030077245 scopus 로고    scopus 로고
    • Triazolam biotransformation by human liver microsomes in vitro: Effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole
    • von Moltke LL, Greenblatt DJ, Harmatz JS, et al. Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole. J Pharmacol Exp Ther. 1996;276:370-379.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 370-379
    • Von Moltke, L.L.1    Greenblatt, D.J.2    Harmatz, J.S.3
  • 17
    • 0025635804 scopus 로고
    • Gas chromatographic analysis of alprazolam in plasma: Replicability, stability and specificity
    • Greenblatt DJ, Javaid JI, Locniskar A, Harmatz JS, Shader RI. Gas chromatographic analysis of alprazolam in plasma: replicability, stability and specificity. J Chromatogr. 1990;534:202-207.
    • (1990) J Chromatogr , vol.534 , pp. 202-207
    • Greenblatt, D.J.1    Javaid, J.I.2    Locniskar, A.3    Harmatz, J.S.4    Shader, R.I.5
  • 18
    • 0024294177 scopus 로고
    • High-performance liquid chromatographic assay of adinazolam and its desmethyl metabolite
    • Locniskar A, Greenblatt DJ. High-performance liquid chromatographic assay of adinazolam and its desmethyl metabolite. J Chromatogr. 1988;424:215-217.
    • (1988) J Chromatogr , vol.424 , pp. 215-217
    • Locniskar, A.1    Greenblatt, D.J.2
  • 19
    • 0024556550 scopus 로고
    • Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo
    • Greenblatt DJ, Ehrenberg BL, Gunderman J, et al. Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo. Clin Pharmacol Ther. 1989;45:356-365.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 356-365
    • Greenblatt, D.J.1    Ehrenberg, B.L.2    Gunderman, J.3
  • 20
    • 0027931014 scopus 로고
    • Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: Kinetic-dynamic studies
    • Greenblatt DJ, Harmatz JS, Gouthro TA, Locke J, Shader RI. Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: kinetic-dynamic studies. Clin Pharmacol Ther. 1994;56:100-111.
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 100-111
    • Greenblatt, D.J.1    Harmatz, J.S.2    Gouthro, T.A.3    Locke, J.4    Shader, R.I.5
  • 21
    • 0026668101 scopus 로고
    • Pharmacokinetics and pharmacodynamics of oral diazepam: Effect of dose, plasma concentration, and time
    • Friedman H, Greenblatt DJ, Peters GR, et al. Pharmacokinetics and pharmacodynamics of oral diazepam: effect of dose, plasma concentration, and time. Clin Pharmacol Ther. 1992;52:139-150.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 139-150
    • Friedman, H.1    Greenblatt, D.J.2    Peters, G.R.3
  • 22
    • 0030807271 scopus 로고    scopus 로고
    • Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans
    • Kaplan GB, Greenblatt DJ, Ehrenberg BL, et al. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol. 1997;37:693-703.
    • (1997) J Clin Pharmacol , vol.37 , pp. 693-703
    • Kaplan, G.B.1    Greenblatt, D.J.2    Ehrenberg, B.L.3
  • 23
    • 0019825066 scopus 로고
    • Simultaneous pharmacokinetic and pharmacodynamic modeling
    • Colburn WA. Simultaneous pharmacokinetic and pharmacodynamic modeling. J Pharmacokinet Biopharm. 1981;9:367-388.
    • (1981) J Pharmacokinet Biopharm , vol.9 , pp. 367-388
    • Colburn, W.A.1
  • 24
    • 0018394195 scopus 로고
    • Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine
    • Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharmacol Ther. 1979;25:358-371.
    • (1979) Clin Pharmacol Ther , vol.25 , pp. 358-371
    • Sheiner, L.B.1    Stanski, D.R.2    Vozeh, S.3    Miller, R.D.4    Ham, J.5
  • 26
    • 0025051493 scopus 로고
    • Benzodiazepine concentrations in brain directly reflect receptor occupancy: Studies of diazepam, lorazepam, and oxazepam
    • Greenblatt DJ, Sethy VH. Benzodiazepine concentrations in brain directly reflect receptor occupancy: studies of diazepam, lorazepam, and oxazepam. Psychopharmacology (Berl). 1990;102:373-378.
    • (1990) Psychopharmacology (Berl) , vol.102 , pp. 373-378
    • Greenblatt, D.J.1    Sethy, V.H.2
  • 27
    • 0008271939 scopus 로고
    • Principles of pharmacokinetics and pharmacodynamics
    • Nemeroff CB, Schatzberg AF, eds. Washington, DC: American Psychiatric Press
    • Greenblatt DJ. Principles of pharmacokinetics and pharmacodynamics. In: Nemeroff CB, Schatzberg AF, eds. The American Psychiatric Press Textbook of Pyschopharmacology. Washington, DC: American Psychiatric Press; 1995:125-136.
    • (1995) The American Psychiatric Press Textbook of Pyschopharmacology , pp. 125-136
    • Greenblatt, D.J.1
  • 28
    • 0033839612 scopus 로고    scopus 로고
    • Kinetics and dynamics of lorazepam during and after continuous intravenous infusion
    • Greenblatt DJ, von Moltke LL, Ehrenberg BL, et al. Kinetics and dynamics of lorazepam during and after continuous intravenous infusion. Crit Care Med. 2000;28:2750-2757.
    • (2000) Crit Care Med , vol.28 , pp. 2750-2757
    • Greenblatt, D.J.1    Von Moltke, L.L.2    Ehrenberg, B.L.3
  • 29
    • 0026734454 scopus 로고
    • Pharmacodynamic modeling of anesthetic EEG drug effects
    • Stanski DR. Pharmacodynamic modeling of anesthetic EEG drug effects. Annu Rev Pharmacol Toxicol. 1992;32:423-447.
    • (1992) Annu Rev Pharmacol Toxicol , vol.32 , pp. 423-447
    • Stanski, D.R.1
  • 30
    • 0020315441 scopus 로고
    • Kinetics of pharmacologic response
    • Holford NH, Sheiner LB. Kinetics of pharmacologic response. Pharmacol Ther. 1982;16:143-166.
    • (1982) Pharmacol Ther , vol.16 , pp. 143-166
    • Holford, N.H.1    Sheiner, L.B.2
  • 31
    • 0025373724 scopus 로고
    • The use of kinetic-dynamic interactions in the evaluation of drugs
    • Campbell DB. The use of kinetic-dynamic interactions in the evaluation of drugs. Psychopharmacology (Berl). 1990;100:433-450.
    • (1990) Psychopharmacology (Berl) , vol.100 , pp. 433-450
    • Campbell, D.B.1
  • 32
  • 33
    • 0024316110 scopus 로고
    • Adinazolam pharmacokinetics and behavioral effects following administration of 20-60 mg oral doses of its mesylate salt in healthy volunteers
    • Fleishaker JC, Phillips JP. Adinazolam pharmacokinetics and behavioral effects following administration of 20-60 mg oral doses of its mesylate salt in healthy volunteers. Psychopharmacology (Berl). 1989;99:34-39.
    • (1989) Psychopharmacology (Berl) , vol.99 , pp. 34-39
    • Fleishaker, J.C.1    Phillips, J.P.2
  • 34
    • 0031952437 scopus 로고    scopus 로고
    • Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man
    • Venkatakrishnan K, von Moltke LL, Duan SX, Fleishaker JC, Shader RI, Greenblatt DJ. Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J Pharm Pharmacol. 1998;50:265-274.
    • (1998) J Pharm Pharmacol , vol.50 , pp. 265-274
    • Venkatakrishnan, K.1    Von Moltke, L.L.2    Duan, S.X.3    Fleishaker, J.C.4    Shader, R.I.5    Greenblatt, D.J.6
  • 35
    • 0031059782 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of adinazolam: Multi-ethnic comparisons
    • Ajir K, Smith M, Lin KM, et al. The pharmacokinetics and pharmacodynamics of adinazolam: multi-ethnic comparisons. Psychopharmacology (Berl). 1997;129:265-270.
    • (1997) Psychopharmacology (Berl) , vol.129 , pp. 265-270
    • Ajir, K.1    Smith, M.2    Lin, K.M.3
  • 36
    • 0026737667 scopus 로고
    • Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs
    • Mandema JW, Danhof M: Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs. Clin Pharmacokinet. 1992;23:191-215.
    • (1992) Clin Pharmacokinet , vol.23 , pp. 191-215
    • Mandema, J.W.1    Danhof, M.2
  • 37
    • 13144307073 scopus 로고    scopus 로고
    • Ketoconazole inhibition of triazolam and alprazolam clearance: Differential kinetic and dynamic consequences
    • Greenblatt DJ, Wright CE, von Moltke LL, et al. Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences. Clin Pharmacol Ther. 1998;64:237-247.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 237-247
    • Greenblatt, D.J.1    Wright, C.E.2    Von Moltke, L.L.3
  • 38
    • 13144257695 scopus 로고    scopus 로고
    • Inhibition of triazolam clearance by macrolide antimicrobial agents: In vitro correlates and dynamic consequences
    • Greenblatt DJ, von Moltke LL, Harmatz JS, et al. Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences. Clin Pharmacol Ther. 1998;64:278-285.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 278-285
    • Greenblatt, D.J.1    Von Moltke, L.L.2    Harmatz, J.S.3
  • 39
    • 13144254260 scopus 로고    scopus 로고
    • Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo
    • Greenblatt DJ, Harmatz JS, von Moltke LL, et al. Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo. Clin Pharmacol Ther. 1998;64:553-561.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 553-561
    • Greenblatt, D.J.1    Harmatz, J.S.2    Von Moltke, L.L.3
  • 40
    • 0023715753 scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system
    • Koopmans R, Dingemanse J, Danhof M, Horsten GP, van Boxtel CJ. Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system. Clin Pharmacol Ther. 1988;44:14-22.
    • (1988) Clin Pharmacol Ther , vol.44 , pp. 14-22
    • Koopmans, R.1    Dingemanse, J.2    Danhof, M.3    Horsten, G.P.4    Van Boxtel, C.J.5
  • 41
    • 0031459934 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of stimulatory and sedative effects of alprazolam: Timing performance deficits
    • Lau CE, Heatherington AC. Pharmacokinetic-pharmacodynamic modeling of stimulatory and sedative effects of alprazolam: timing performance deficits. J Pharmacol Exp Ther. 1997;283:1119-1129.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1119-1129
    • Lau, C.E.1    Heatherington, A.C.2


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