Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs

International Journal of Pharmaceutics

Volumn 295, Issue 1-2, 2005, Pages 121-127

  Niemi, Riku ^a   Huuskonen, Juhani ^a,b   Laine, Krista ^a   Järvinen, Tomi ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF JYVÄSKYLÄ   (Finland)

Author keywords

Intraocular pressure; MPV 2426; Physicochemical properties; Prodrugs; Stability; Synthesis

Indexed keywords

4 (6 ACETOXYINDAN 1 YLMETHYL) 3H IMIDAZOL 1 IUM CHLORIDE; 4 (6 BUTYRYLOXYINDAN 1 YLMETHYL) 3H IMIDAZOL 1 IUM CHLORIDE; 4 (6 HYDROXYINDAN 1 YLMETHYL) 3H IMIDAZOL 1 IUM CHLORIDE; 4 (6 PIVALYLOXYINDAN 1 YLMETHYL) 3H IMIDAZOL 1 IUM CHLORIDE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; FADOLMIDINE; PRODRUG; RADOLMIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG PENETRATION; DRUG RELEASE; DRUG STABILITY; DRUG SYNTHESIS; HYDROLYSIS; INTRAOCULAR PRESSURE; LIPOPHILICITY; NONHUMAN; PH; PRIORITY JOURNAL; RABBIT;

EID: 17644393103     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.02.002     Document Type: Article

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