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It has already been observed that the efficiency of the formation of a zwitterion depends on the Lewis basicity of the internal amine substituent. See Reference [17].
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Alizarine complexone has hitherto been used as a sensor for pH, as well as lanthanide and fluoride ions. See: a) M. A. Leonard, T. S. West, J. Chem. Soc. 1960, 4477-4485; b) R. Belcher, M. A. Leonard, T. S. West, J. Chem. Soc. 1958, 2390-2393.
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Alizarine complexone has hitherto been used as a sensor for pH, as well as lanthanide and fluoride ions. See: a) M. A. Leonard, T. S. West, J. Chem. Soc. 1960, 4477-4485; b) R. Belcher, M. A. Leonard, T. S. West, J. Chem. Soc. 1958, 2390-2393.
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This color change cannot be brought about by a change in pH owing to the presence of a large excess of phosphate buffer, which maintains the pH at 7.0 throughout the entire titration.
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67
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17644407498
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note
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[16a]
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69
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Earlier examples of indicators in competition with the desired analyte were mainly focused on biological systems, see: a) M. A. Roberts, R. A. Durst, Anal. Chem. 1995, 67, 482-491; b) C. Beyer, I. H. Alting, Clin. Chem. 1996, 42, 313-318.
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