Immunological and protective effects of diepitopic subunit dental caries vaccines

Infection and Immunity

Volumn 73, Issue 5, 2005, Pages 2797-2804

  Smith, Daniel J ^a   King, William F ^a   Rivero, Joy ^a   Taubman, Martin A ^a  

^a FORSYTH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTYLALANYLASPARAGINYLPHENYLALANYLASPARTYLSERYLISOLEUCYLARGINYLVALYL ASPARTYLALANYLVALYLASPARTYLASPARAGINYLASPARTYLVALYLASPARTYLALANYLASPARTYLALANYL LEUCYLLEUCYLGLUTAMINYLISOLEUCINE; BINDING PROTEIN; EPITOPE; GLUCAN BINDING PROTEIN B; GLUCOSYLTRANSFERASE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; LYSYLSERYLASPARAGINYLALANYLALANYLTHREONYLTYROSYLSERYLISOLEUCYLASPARAGINYL ALANYLISOLEUCYLISOLEUCYLASPARAGINYLSERYLLYSYLSERYLVALYLSERYLASPARTIC ACID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; POLYPEPTIDE; STREPTOCOCCUS VACCINE; THREONYLALANYLGLYCYLGLUTAMINYLTHREONYLISOLEUCYLLYSYLGLYCYLGLUTAMINYLLYSYL LEUCYLTYROSYLPHENYLALANYLLYSYLALANYLASPARAGINYLGLYCYLGLUTAMINYLGLUTAMINYLVALYL LYSYLGLYCINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN ANTIBODY REACTION; ARTICLE; BACTERIAL STRAIN; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DENTAL CARIES; DRUG EFFICACY; DRUG SYNTHESIS; FEMALE; IMMUNIZATION; IMMUNOLOGY; INFECTION PREVENTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RAT; STREPTOCOCCUS INFECTION; STREPTOCOCCUS MUTANS; STREPTOCOCCUS SOBRINUS;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL VACCINES; DENTAL CARIES; EPITOPES; FEMALE; GLUCOSYLTRANSFERASES; GLYCOPROTEINS; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS MUTANS;

EID: 17644370699     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.5.2797-2804.2005     Document Type: Article

References (26)

1. Abo, H., T. Matsumura, T. Kodama, H. Ohta, K. Fukui, K. Kato, and H. Kagawa. 1991. Peptide sequences for sucrose splitting and glucan binding within Streptococcus sobrinus glucosyltransferase (water-insoluble glucan synthetase). J. Bacteriol. 173:989-996.
2. Banas, J. A., and M. M. Vickerman. 2003. Glucan-binding proteins of the oral streptococci. Crit. Rev. Oral Biol. Med. 14:89-99.
3. Guo, J. H., R. Jia, M. W. Fan, Z. Bian, Z. Chen, and B. Peng. 2004. Construction and immunogenic characterization of a fusion anti-caries DNA vaccine against PAc and glucosyltransferase I of Streptococcus mutans. J. Dent. Res. 83:266-270.
4. Hamada, S., and H. D. Slade. 1980. Biology, immunology and cariogenicity of Streptococcus mutans. Microbiol. Rev. 44:331-384.
5. Jespersgaard, C., G. Hajishengallis, Y. Huang, M. W. Russell, D. J. Smith, and S. M. Michalek. 1999. Protective immunity against Streptococcus mutans infection in mice after intranasal immunization with the glucan-binding region of S. mutans glucosyltransferase. Infect. Immun. 67:6543-6549.
6. Kato, C., Y. Nakano, M. Lis, and H. K. Kuramitsu. 1992. Molecular genetic analysis of the catalytic site of Streptococcus mutans glucosyltransferases. Biochem. Biophys. Res. Commun. 189:1184-1188.
7. Keyes, P. H., and H. V. Jordan. 1964. Periodontal lesions in the Syrian hamster. III. Findings related to an infectious and transmissible component. Arch. Oral Biol. 9:377.
8. Koga, T., T. Oho, Y. Shimazaki, and Y. Nakano. 2002. Immunization against dental caries. Vaccine 20:2027-2044.
9. Lis, M., T. Shiroza, and H. K. Kuramitsu. 1995. Role of the C-terminal direct repeating units of the Streptococcus mutans glucosyltransferase-S in glucan binding. Appl. Environ. Microbiol. 61:2040-2042.
10. Mattos-Graner, R. O., S. Jin, W. F. King, T. Chen, D. J. Smith, and M. J. Duncan. 2001. Cloning of the Streptococcus mutans gene encoding glucan binding protein B and analysis of genetic diversity and protein production in clinical isolates. Infect. Immun. 69:6931-6941.
11. Merrifield, R. B. 1963. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 85:2149-2154.
12. Mooser, G., S. Hefta, R. J. Paxton, J. E. Shively, and T. D. Lee. 1991. Isolation and sequence of an active-site peptide containing a catalytic aspartic acid from two Streptococcus sobrinus alpha-glucosyltransferases. J. Biol. Chem. 266:8916-8922.
13. Mooser, G., and C. Wong. 1988. Isolation of a glucan-binding domain of glucosyltransferase (1,6-alpha-glucan synthase) from Streptococcus sobrinus. Infect. Immun. 56:880-884.
14. Smith, D. J. 2002. Dental caries vaccines: prospects and concerns. Crit. Rev. Oral Biol. Med. 13:335-349.
15. Smith, D. J., H. Akita, W. F. King, and M. A. Taubman. 1994. Purification and antigenicity of a novel glucan-binding protein of Streptococcus mutans. Infect. Immun. 62:2545-2552.
16. Smith, D. J., W. F. King, L. A. Barnes, Z. S. Peacock, and M. A. Taubman. 2003. Immunogenicity and protective immunity induced by synthetic peptides associated with putative immunodominant regions of Streptococcus mutans glucan-binding protein B. Infect. Immun. 71:1179-1184.
17. Smith, D. J., and M. A. Taubman. 1996. Experimental immunization of rats with a Streptococcus mutans 59-kilodalton glucan-binding protein protects against dental caries. Infect. Immun. 64:3069-3073.
18. Smith, D. J., M. A. Taubman, C. J. Holmberg, J. W. Eastcott, W. F. King, and P. Ali-Salaam. 1993. Antigenicity and immunogenicity of a synthetic peptide derived from a glucan-binding domain of mutans streptococcal glucosyltransferase. Infect. Immun. 61:2899-2905.
19. Smith, D. J., M. A. Taubman, W. F. King, S. Eida, J. R. Powell, and J. Eastcott. 1994. Immunological characteristics of a synthetic peptide associated with a catalytic domain of mutans streptococcal glucosyltransferase. Infect. Immun. 62:5470-5476.
20. Tam, J. P. 1988. Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc. Natl. Acad. Sci. USA 85:5409-5413.
21. Taubman, M. A., C. J. Holmberg, and D. J. Smith. 1995. Immunization of rats with synthetic peptide constructs from the glucan-binding or catalytic regions of mutans streptococcal glucosyltransferase protects against dental caries. Infect. Immun. 63:3088-3093.
22. Taubman, M. A., C. J. Holmberg, D. J. Smith, and J. W. Eastcott. 1995. T and B cell epitopes from peptide sequences associated with glucosyltransferase function. Clin. Immunol. Immunopathol. 76:s95.
23. Taubman, M. A., D. J. Smith, C. J. Holmberg, and J. W. Eastcott. 2000. Coimmunization with complementary glucosyltransferase peptides results in enhanced immunogenicity and protection against dental caries. Infect. Immun. 68:2698-2703.
24. Taubman, M. A., C. J. Holmberg, and D. J. Smith. 2001. Diepitopic construct of functionally and epitopically relevant complementary peptides enhances immunogenicity, reactivity with glucosyltransferase, and protection from dental caries. Infect. Immun. 69:4210-4216.
25. Yu, H., Y. Nakano, Y. Yamashita, T. Oho, and T. Koga. 1997. Effects of antibodies against cell surface protein antigen PAc-glucosyltransferase fusion proteins on glucan synthesis and cell adhesion of Streptococcus mutans. Infect. Immun. 65:2292-2298.
26. Zhang, P., C. Jespersgaard, L. Lamberty-Mallory, J. Katz, Y. Huang, G. Hajishengallis, and S. M. Michalek. 2002. Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infection. Infect. Immun. 70:6779-6787.