Probing the structural features of volatile anesthetic binding sites with synthetic peptides

Toxicology Letters

Volumn 100-101, Issue , 1998, Pages 369-375

  Johansson, Jonas S ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Anesthetic; Anesthetic mechanisms; Fluorescence; Halothane; Protein interaction; Protein stability; Synthetic peptide

Indexed keywords

GUANIDINE; HALOTHANE; INHALATION ANESTHETIC AGENT; SYNTHETIC PEPTIDE;

AMINO ACID SEQUENCE; BINDING SITE; CONFERENCE PAPER; DENATURATION; DRUG MECHANISM; DRUG PROTEIN BINDING; FLUORESCENCE; MODEL; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANESTHETICS, INHALATION; BINDING SITES; HALOTHANE; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION; PROTEIN DENATURATION; SPECTROMETRY, FLUORESCENCE;

EID: 17544387339     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00209-4     Document Type: Conference Paper

References (28)

1. Abraham, M.H., McGowan, J.C., 1987. The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography. Chromatographia 23, 243-246.
2. Antognini, J.F., 1993. Hypothermia eliminates isoflurane requirements at 20°C. Anesthesiology 78, 1152-1156.
3. Betz, S.F., Liebman, P.A., DeGrado, W.F., 1997. De novo design of native proteins: characterization of proteins intended to fold into antiparallel, Rop-like, four-helix bundles. Biochemistry 36, 2450-2458.
4. 2) method for characterizing anesthetic binding to proteins: analysis of isoflurane binding to albumin. Biochemistry 31, 7069-7076.
5. 19F-NMR study. Proc. Natl. Acad. Sci. USA 90, 6478-6482.
6. Eckenhoff, R.G., Shuman, H., 1993. Halothane binding to soluble proteins determined by photoaffinity labeling. Anesthesiology 79, 96-106.
7. Eckenhoff, R.G., 1996. An inhalational anesthetic binding domain in the nicotinic acetylcholine receptor. Proc. Natl. Acad. Sci. USA 93, 2807-2810.
8. 15N NMR. J. Mol. Biol. 253, 576-589.
9. Forman, S.A., Miller, K.W., Yellen, G., 1995. A discrete site for general anesthetics on a postsynaptic receptor. Mol. Pharmacol. 48, 574-581.
10. Franks, N.P., Lieb, W.R., 1994. Molecular and cellular mechansims of general anaesthesia. Nature 367, 607-614.
11. Gibney, B.R., Johansson, J.S., Rabanal, F., Skalicky, J.J., Wand, A.J., Dutton, P.L., 1997. Global topology & stability and local structure & dynamics in a synthetic spin-labeled four-helix bundle protein. Biochemistry 36, 2798-2806.
12. Johansson, J.S., Eckenhoff, R.G., Dutton, P.L., 1995. Binding of halothane to serum albumin demonstrated using tryptophan fluorescence. Anesthesiology 83, 316-324.
13. Johansson, J.S., Rabanal, F., Dutton, P.L., 1996. Binding of the volatile anesthetic halothane to the hydrophobic core of a tetra-α-helix bundle protein. J. Pharmacol. Exp. Ther. 279, 56-61.
14. Johansson, J.S., 1997. Binding of the volatile anesthetic chloroform to albumin demonstrated using tryptophan fluorescence quenching. J. Biol. Chem. 272, 17961-17965.
15. 2+ -ATPase. FEBS Lett. 402, 189-192.
16. Lee, J., Pilch, P.F., Shoelson, S.E., Scarlata, S.F., 1997. Conformational changes in the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. Biochemistry 36, 2701-2708.
17. Mok, Y-K., De Prat Gay, G., Butler, P.J., Bycroft, M., 1996. Equilibrium dissociation and unfolding of the dimeric human papillomavirus strain-16 E2 DNA-binding domain. Protein Sci. 5, 310-319.
18. Náray-Szabó, G., 1993. Analysis of molecular recognition: Steric, electrostatic and hydrophobic complementarily. J. Mol. Recognit. 6, 205-210.
19. Pace, C.N., 1986. Determination and analysis of urea and guanidine hydrochloride denaturation curves. Methods Enzymol. 131, 266-280.
20. Rabanal, F., DeGrado, W.F., Dutton, P.L., 1996. Towards the synthesis of a photosynthetic reaction center maquette: A cofacial porphyrin pair assembled between two subunits of a synthetic four-helix bundle multi-heme protein. J. Am. Chem. Soc. 118, 473-474.
21. Robertson, D.E., Farid, R.S., Moser, C.C., Urbauer, J.L., Mulholland, S.E., Pidikiti, R., Lear, J.D., Wand, A.J., DeGrado, W.F, Dutton, P.L., 1994. Design and synthesis of multihaem proteins. Nature 368, 425-432.
22. Shibata, A., Morita, K., Yamashita, T., Kamaya, H., Ueda, I., 1991. Anesthetic-protein interaction: effects of volatile anesthetics on the secondary structure of poly(L-lysine). J. Pharm. Sci. 80, 1037-1041.
23. Silva, J.L., Weber, G., 1993. Pressure stability of proteins. Annu Rev. Phys. Chem. 44, 89-113.
24. Takenoshita, M., Steinbach, J.H., 1991. Halothane blocks low-voltage-activated calcium current in rat sensory neurons. J. Neurosci. 11, 1404-1412.
25. Tanner, J.W., Eckenhoff, R.G., Liebman, P.A., 1997. Protein stabilization by an inhalational anesthetic. Biophys. J. 72, 417.
26. Trudell, J.R., 1977. A unitary theory of anesthesia based on lateral phase separations in nerve membranes. Anesthesiology 46, 5-10.
27. von Heijne, G., 1994. Membrane proteins: from sequence to structure. Annu. Rev. Biophys. Biomol. Struct. 23, 167-192.
28. Wann, K.T., MacDonald, A.G., 1988. Actions and interactions of high pressure and general anaesthetics. Prog. Neurobiol. 30, 271-307.