Standardized in situ AgNOR analysis in breast pathology: Diagnostic and cell kinetic implications

Pathology Research and Practice

Volumn 195, Issue 4, 1999, Pages 219-229

  Bànkfalvi, Àgnes ^d   Öfner, Dietmar ^a   Schmid, Kurt Werner ^d   Schmitz, Klaus Jürgen ^d   Breukelmann, Dirk ^d   Krech, Rainer ^b   Böcker, Werner ^c  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b City Hospital   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d NONE

Author keywords

Breast pathology; Diagnosis; Standardized AgNOR analysis

Indexed keywords

PROTEIN;

ARTICLE; BREAST ADENOMA; BREAST CANCER; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST DISEASE; BREAST HYPERPLASIA; BREAST LESION; CARCINOMA IN SITU; CELL KINETICS; CHROMOSOME NOR; CONTROLLED STUDY; DIAGNOSIS RELATED GROUP; DIAGNOSTIC VALUE; HUMAN; HUMAN TISSUE; INVASIVE CARCINOMA; LABORATORY; LUNG CARCINOMA; MAJOR CLINICAL STUDY; MORPHOMETRICS; PROGNOSIS; SILVER STAINING; TUMOR DIFFERENTIATION; TUMOR GROWTH;

EID: 17444433793     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(99)80038-7     Document Type: Article

References (60)

1. Agarwal PK, Mehrotra A, Chandra T (1995) Diagnostic relevance of silver stained nucleolar organiser region (AgNORs) in benign and malignant breast lesions. Indian J Exp Biol 33: 715-720
2. Aubele M, Auer G, Gais P, Jütting U, Radenacker K, Voss A (1994) Nucleolus organiser regions (AgNORs) in ductal mammary carcinoma. Comparison with classification and prognosis. Pathol Res Pract 190: 129-137
3. Aubele M, Biesterfeld S, Derenzini M., Hufnagl P, Martin H, Öfner D, Ploton D, Rüschoff J (1994) Guidelines of AgNOR quantitation. Zentralbl Pathol 140: 107-108
4. Bànkfalvi A, Navabi H, Bier B, Böcker W, Jasani B, Schmid KW (1994) Wet autoclave pre-treatment for antigen retrieval in diagnostic immunohistochemistry. J Pathol 174: 223-228
5. Böcker W, Bier B, Freytag G, Brömmelkamp B, Jarasch E-D, Edel G, Dockhorn-Dworniczak B, Schmid KW (1992a) An immunohistochemical study of the breast using antibodies to basal and luminal keratins, α-smooth muscle actin, vimentin, collagen IV and laminin. I. Normal breast and benign proliferative lesions. Virchows Archiv 421: 315-322
6. Böcker W, Bier B, Freytag G, Brömmelkamp B, Jarasch E-D, Edel G, Dockhorn-Dworniczak B, Schmid KW (1992b) An immunohistochemical study of the breast using antibodies to basal and luminal keratins, α-smooth muscle actin, vimentin, collagen IV and laminin. II. Epitheliosis and ductal carcinoma in situ. Virchows Archiv 421: 323-330
7. Crocker J, Boldy DA, Egan MJ (1989) How should we count AgNORs? Proposal for a standardized approach J Pathol 158: 185-188
8. Crocker J (1990) Curr Top Pathol 82: 91-149
9. Derenzini M, Betts CM, Trerè D, Mambelli V, Millis RR, Eusebi V, Cancellieri A Diagnostic value of silver-stained interphasic nucleolar organiser regions in breast cancer. Ultrastruct Pathol 14: 233-245
10. Derenzini M, Nardi F, Farabegoli F, Ottinetti A, Roncaroli F, Bussolati G (1989) Distribution of silver stained interphasic nucleolar organiser regions as a parameter to distinguish neoplastic from non neoplastic reactive cells in human effusions. Acta Cytol 33: 491-498
11. Derenzini M, Pession A, Trere D (1990) The quantity of nucleolar silver stained proteins is related to proliferating activity in cancer cells. Lab Invest 63: 137-140
12. Derenzini M, Romagnoli T, Ceccarelli c, Eusebi V (1988) Fixatives and silver stainability of the NOR proteins at light microscopical level. J Histochem Cytochem 36: 1453-1459
13. Derenzini M, Sirri V, Trerè D, Ochs RL (1995) The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells. Lab Invest 73: 497-502
14. Derenzini M, Trerè D (1991a) Importance of interphase nucleolar organiser regions in tumor pathology. Virchows Arch 61: 1-8
15. Derenzini M, Trerè D (1991b) Standardization of interphase AgNOR measurement by means of an automated image analysis system using lymphocytes as an internal control. J Pathol 165: 337-342
16. Derenzini M, Trere D (1994) AgNOR proteins as a parameter of the rapidity of cell proliferation. Zentralbl Pathol 140: 7-10
17. Dervan PA, Gilmartin LG, Loftus B, Carney DN (1989) Argyropphilic nucleolar organiser region counts correlate with Ki-67 scores. Am J Clin Pathol 92: 401-407
18. Egan MJ, Crocker J (1992) Nucleolar organiser regions in pathology. Br J Cancer 65: 1-7
19. Ellis IO, Elston CW (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long term follow up. Histopathology 19: 403-410
20. Giri DD, Nottingham JF, Lawry J, Dundas SA, Underwood JC (1989) Silver binding nucleolar organiser regions (AgNORs) in benign and malignant breast lesions: correlation with ploidy and growth phase by DNA flow cytometry. J Pathol 157: 307-313
21. Hall PA, Crocker J, Watts A, Stansfeld AG (1988) A comparison of nucleolar organiser region staining and Ki-67 immunostaining in non-Hodgkin's lymphoma. Histopathology 12: 373-381
22. Hara A, Hirayama H, Sakai N, Yamada H, Tanaka T, Mori H (1990) Correlation between nucleolar organiser region staining and Ki-67 immunostaining in human gliomas. Surg Neurol 33: 320-324
23. Holland R, Peterse J, Millis R, Eusebi V, Faverly D, Vande-Vijver MJ, Zafrani B (1994) Ductal carcinoma in situ: a proposal for a new classification. Semin Diagn Pathol 11: 167-180
24. Jewell SD, Cordial CR (1996) Silver staining of nucleolar organiser regions. J Histotechnol 19: 241-256
25. Kakeji Y, Korenaga D, Tsujitani S, Haraguchi M, Maehara Y, Sugimachi K (1991) Predictive value of Ki-67 and argyrophilic nucleolar organiser region staining for lymph node metastasis in gastric cancer. Cancer Res 51: 3503-3506
26. Lakhani SR, Collins N, Stratton MR, Sloane JP (1995) Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16Q and 17p. J Clin Pathol. 48: 611-615
27. Lakhani SR, Slack DN, Harmoudi RA, Collins N, Stratton MR, Sloane JP (1996) Detection of allelic imbalance indicates that a proportion of mammary hyperplasias of usual type are clonal, neoplastic proliferations. Lab Invest 74: 129-135
28. Lipponen P, Aaltomaa S, Syrjanen K (1993) Morphometric quantitation of nucleolar organiser region proteins in breast carcinoma. Anal Quant Cytol Histol 75: 311-316
29. Öfner D, Aubele M, Biesterfeld S, Derenzini M, Giminez-Mas J, Hufnagl P, Ploton D, Trerè D, Rüschoff J (1995) Guidelines of AgNOR quantification - first update. Virchows Arch 427: 341-342
30. Öfner D, Bankfalvi A, Riehemann K, Bier B, Böcker W, KW Schmid (1994) Wet autoclave pretreatment improves the visualisation of silver stained nucleolar organiser region associated proteins (AgNORs) ion routinely formalin fixed and paraffin-embedded tissues. Mod Pathol 7: 946-950
31. Öfner D, Bier B, Heinrichs S, Berghorn M, Dünser M, Hagemann H-A, Langer D, Böcker W, Schmid KW (1996) Demonstration of silver-stained nucleolar organiser regions associated proteins (AgNORs) after wet autoclave pretreatment in breast carcinoma. Breast Cancer Res Treat 39: 165-167
32. Öfner D, Hittmair A, Marth C, Öfner C, Tötsch M, Daxenbichler G, Mikuz G, Margreiter R, Schmid KW (1992) Relationship between quantity of silver stained nucleolar organiser regions associated proteins (AgNORs) and population doubling time in ten breast cancer cell lines. Path Res Pract 188: 742-746
33. Öfner D, Riedmann B, Maier H, Hittmair A, Rumer A, Tötsch M, Spechtenhauser B, Böcker W, Schmid KW (1995) Standardized staining and analysis of argyrophilic nucleolar organiser region associated proteins (AgNORs) in radically resected colorectal adenocarcinoma - correlation with tumor stage and long-term survival. J Pathol 175: 441-448
34. Öfner D, Riedmann B, Maier H, Weiss H, Schwab G, Schmid KW (1997) Proliferative activity assessed by standardized AgNOR analysis: a major prognostic factor in radically resected gastric carcinoma. GCC Proc 1: 555-558
35. Öfner D, Schmid JW (1995) Clinical significance of nucleolar organiser region associated proteins in tumor pathology. Virchows Arch 427: 340
36. Öfner D, Schmid KW (1996) Standardized AgNOR analysis: its usefulness in surgical oncology. Histochem Cell Biol 106: 193-160
37. Öfner D, Weiss H, Sandblicher P, Maier H, Schmid KW (1996) Standardized AgNOR analysis in colorectal adenocarcinoma: correlation with chemotherapy efficacy. Cancer Detect Prev 20: 473-477
38. Page DL, Anderson TJ, Rogers LW (1988) Epithelial hyperplasia. In: Page DL, Anderson TJ (Eds) Diagnostic histopathology of the breast, pp 120-156. Churchill Livingstone, Edinburgh
39. Page DL, Rogers LW (1992) Combined histologic and cytologic criteria for the diagnosis of mammary atypical ductal hyperplasia. Human Pathol 23: 1095-1097
40. Piffkò J, Bànkfalvi A, Öfner D, Bryne M, Rasch D, Joos U, Böcker W, Schmid KW (1997) Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumor front of oral squamous cell carcinomas. Br J Cancer 75: 1543-1546
41. Piffkò J, Bànkfalvi A, Öfner D, Rasch D, Joos U, Böcker W, Schmid KW (1997) Standardized AgNOR analysis of the invasive tumor front in oral squamous cell carcinomas. J Pathol 182: 450-456
42. Ploton D, Menager M, Jeannesson P, Himber G, Pigeon F, Adnet JJ (1986) Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organiser region at the optical level. Histochem J 18: 5-14
43. Poller DN, Roberts EC, Bell JA, Elston CW, Blamery RW, Ellis IO (1994) P53 protein expression in mammary ductal carcinoma in situ: relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein. Hum Pathol 24: 463-468
44. Raymond WA, Leong AS (1989) Nucleolar organiser regions related to growth fraction in human breast carcinoma. Human Pathol 20: 741-746
45. Reeves BR, Casey G, Honeycombe JR, Smith A (1984) Correlation of differentiation state and silver staining of nucleolar organizers in promyelocytic leukaemia cell line HL-60. Cancer Genet Cytogenet 13: 159-165
46. Roller E, Fritz P, Wicherek C, Klumpp B, Lauinger J, Mischlinski A, Wanner B, Schumacher K (1993) Nucleolar organiser regions in human breast cancer. Zentralbl Pathol 139: 195-199
47. Rosai J (1991) Borderline epithelial lesions of the breast. Am J Surg Pathol 15: 209-221
48. Roussel P, Hernandez-Verdun D (1994) Identification of AgNOR proteins, markers of proliferation related to ribosomal gene activity. Exp Cancer Res 214: 465-472
49. Rüschoff J, Neumann K, Contractor H, Plate K, Thomas C (1990) Assessment of nucleolar organiser regions by automatic image analysis in breast cancer: correlation with DNA content, proliferation rate, receptor status and histopathology grading. J Cancer Res Clin Oncol 116: 480-485
50. Rüschoff J, Plate KH, Contractor H, Kern S, Zimmermann R, Thomas C (1990) Evaluation of nucleolus organiser regions (NOR) by automatic image analysis: a contribution to standardization. J Pathol 161: 113-118
51. Schnitt SJ, Connolly JL, Tavassoli FA, Fechner RE, Kempson RL, Gelman R, Page D (1992) Interobserver reproducibility in the diagnosis of ductal proliferative breast lesions using standardized criteria. Am J Surg Pathol 16: 1133-1143
52. Silverstein MJ, Poller DN, Waisman JR, Colburn WJ, Barth A, Gierson ED, Lewinsky B, Gamagami P, Slamon DJ (1995) Prognostic classification of breast ductal carcinoma in situ. Lancet 345: 1154-1157
53. Sloane JP, Amendoeira I, Apostolikas N, Bellocq JP, Bianchi S, Bocker W, Bussolati G, Connolly CE, deMiguel C, Dervan P, Drijkoningen R, Elston CW, Faverly D, Gad A, Holland R, Jacquemier J, Lacerda M, Lindgren A, Martinez-Penuela J, Peterse JL, Rank F, Tsakraklides V, de-Wolf C, Zafrani B (1997) Guidelines for pathology - supplement to European guidelines for quality assurance in mammography screening. Report by the Pathology Working Group of the European Community. Pathologe 18: 71-88
54. Smith R, Crocker J (1988) Evaluation of nucleolar organiser region-associated proteins in breast malignancy. Histopathology 12: 113-125
55. Tavassoli FA, Man YG (1995) Morphofunctional features of intraductal hyperplasia, atypical intraductal hyperplasia, and various grades of intraductal carcinoma. The Breast Journal 1: 155-162
56. Tavassoli FA (1992) Atypical hyperplasia: A morphologic risk factor for subsequent development of invasive breast carcinoma. Cancer Invest 10: 433-441
57. Tavassoli FA (1992) Intraductal hyperplasias, ordinary and atypical. In: Tavassoli FA (Ed) Pathology of the Breast, pp 160-163. Appleton and Lange, New York
58. Tötsch M, Öfner D, Maier H, Watzka SBC, Salzer M, Schmid KW (1995) Argyrophilic nucleolar organiser regions associated proteins (AgNORs) in adenocarcinoma and squamous cell carcinoma of the lung - correlation with tumor stage and long-term survival. Pathol Res Pract 191: 800
59. Trerè D, Farabegoli F, Cancellieri A, Ceccarelli C, Eusebi V, Derenzini M (1991) AgNOR protein quantity in human tumors correlates with the proliferative activity evaluated by bromodeoxyuridine labelling and Ki-67 immunostaining. J Pathol 164: 53-59
60. Trere D, Pession A, Derenzini M (1989) The silver-stained proteins of interphasic nucleolar organiser regions as a parameter of cell duplication rate. Exp Cell Res 184: 131-137