Standardized AgNOR analysis: Its usefulness in surgical oncology

Histochemistry and Cell Biology

Volumn 106, Issue 2, 1996, Pages 193-196

  Ofner D ^a   Schmid, K W ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; CHROMOSOME NOR; HUMAN; HUMAN CELL; NONHUMAN; ONCOLOGY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; STANDARDIZATION;

ANIMALIA;

EID: 0029745620     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02484400     Document Type: Review

References (32)

1. Aubele M, Biesterfeld S, Derenzini M, Hufnagl P, Martin H. Öfner D, Ploton D, Rüschoff J (1994) Guidelines of AgNOR quantitation. Zentralbl Pathol 140:107-108
2. Bankfalvi A, Navabi H, Bier B, Böcker W, Jasani B, Schmid KW (1994a) Wet autoclave pretreatment for antigen retrieval in diagnostic immunohistochemistry. J Pathol 174:223-228
3. Bankfalvi A, Riehemann K, Öfner D, Cecchi R, Morgan JM. Piffko J, Böcker W, Jasani B, Schmid KW (1994b) Wet autoclave technique. The simpler method for antigen retrieval. Pathologe 15:345-349
4. Bier B, Bánkfalvi A, Grote L, Blasius S, Öfher D, Böcker W, Jasani B, Schmid KW (1995) Wet autoclave pretreatment for immunohistochemical demonstration of oestrogen receptors in routinely processed breast carcinoma tissue. Histochem J 27:148-154
5. Crocker J, Boldy DA, Egan MJ (1989) How should we count Ag-NORS? Proposals for a standardized approach. J Pathol 158: 185-188
6. Derenzini M, Ploton D (1991) Interphase nucleolar organizer regions in cancer cells. Int Rev Exp Pathol 32:149-192
7. Derenzini M, Trerè D (1991) Importance of interphase nucleolar organizer regions in tumor pathology. Virchows Arch 61:1-8
8. Derenzini M, Trerè D (1992) The coefficient of variation of Ag-NOR protein values: a standardized parameter for cell kinetics evaluation. Proc Histochem Soc 40:600
9. Derenzini M, Pession A, Trerè D (1990) Quantity of nucleolar silver-stained proteins is related to proliferating activity in cancer cells. Lab Invest 63:137-140
10. Hittmair A, Öfner D, Offner F, Feichtinger H, Ensinger C, Rogatsch H, Mikuz G (1994) In vitro investigations of interphase and metaphase argyrophilic nucleolar organizer regions and cellular proliferation in the human urothelial cancer cell line HOK-1. Virchows Arch 424:149-154
11. Hozák P, Roussel P, Hernandez-Verdun D (1992) Procedures for specific detection of silver-stained nucleolar proteins on western blots. J Histochem Cytochem 40:1089-1096
12. Li Q, Hacker GW, Danscher G, Sonnleitner U, Grimelius L (1995) Argyrophilic nucleolar orgunizer regions. A revised version of the Ag-NOR staining technique. Histochem Cell Biol 104: 145-150
13. Öfner D, Schmid KW (1995) Clinical significance of nucleolar organizer region associated proteins in tumour pathology. Virchows Arch 427:340
14. Öfner D, Tötsch M, Sandbichler P, Hallbrucker C, Margreiter R, Mikuz G, Schmid KW (1990) Silver stained nucleolar organizer region proteins (Ag-NORs) as a predictor of prognosis in colonic cancer. J Pathol 162:43-49
15. Öfner D, Hittmair A, Marth C, Öfner C, Tötsch M, Daxenbichler G, Mikuz G, Margreiter R, Schmid KW (1992) Relationship between quantity of silver stained nucleolar organizer regions associated proteins (Ag-NORs) and population doubling time in ten breast cancer cell lines. Pathol Res Pract 188:742-746
16. Öfner D, Bankfalvi A, Richemann K, Bier B, Böcker W, Schmid KW (1994a) Wet autoclave pretreatment improves the visualisation of silver stained nucleolar organizer regions associated proteins (AgNORs) in routinely formalin-fixed and paraffinembedded tissues. Mod Pathol 7:946-950
17. Öfner D, Bankfalvi A, Richemann K, Böcker W, Schmid KW (1994b) Standardized AgNOR staining method on formalin-fixed and paraffin-embedded tissues. Pathologe 15:226-230
18. Öfner D, Aubele M, Biesterfeld S, Derenzini M, Giminez-Mas J, Hufnagl P, Ploton D, Treré D, Rüschoff J (1995a) Guidelines of AgNOR quantification - first update. Virchows Arch 427:341
19. Öfner D, Bier B, Heinrichs S, Berghorn M, Dünser M, Hagemann H-A, Langer D, Böcker W, Schmid KW (1995b) Demonstration of silver-stained nucleolar organizer region associated proteins (AgNORs) after wet autoclave pretreatment in breast carcinoma - correlation to tumor stage and long-term survival. Breast Cancer Res Treat (in press)
20. Öfner D, Riedmann B, Maier H, Hittmair A, Rumer A, Tötsch M, Spechtenhauser B, Böcker W, Schmid KW (1995c) Standardized staining and analysis of argyrophilic nucleolar organizer region associated proteins (AgNORs) in radically resected colorectal adrenocarcinoma - correlation with tumour stage and long-term survival. J Pathol 175:441-448
21. Öfner D, Rüschoff J, Trerè D, Aubele M, Derenzini M, Schmid KW (1995d) Standardized morphometric silver stained nucleolar organizer region associated protein (AgNOR) analysis - basic concepts. Pathol Res Pract 191:236
22. Pession A, Farabegoli F, Trerè D, Novello F, Montanaro L, Sperti S, Rambelli F, Derenzini M(1991) The Ag-NOR proteins and transcription and duplication of ribosomal genes in mammalian cell nucleoli. Chromosoma 100:242-250
23. Ploton D, Bendayan M, Adnet JJ (1983) Ultrastructural localization of Ag-NOR proteins and nucleic acids in reticulated nucleoli. Biol Cell 49:29-34
24. Ploton D, Menager M, Jeannesson P, Himber G, Pigeon F, Adnet JJ (1986) Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level. Histochem J 18:5-14
25. Roussel P, Hernandez-Verdun D (1994) Identification of Ag-NOR proteins, markers of proliferation related to ribosomal gene activity. Exp Cell Res 214:465-472
26. Roussel P, Belenguer P, Amalric F, Hernandez-Verdun D (1992) Nucleolin is an Ag-NOR protein: this property is determined by its amino-terminal domain independently of its phosphorylation state. Exp Cell Res 203:259-269
27. Rüschoff J, Plate KH, Contractor H. Kern S. Zimmermann R, Thomas C (1990) Evaluation of nucleolus organizer regions (NORs) by automatic image analysis: a contribution to standardization. J Pathol 161:113-118
28. Simon R, Altman DG (1994) Statistical aspects of prognostic factor studies in oncology. Br J Cancer 69:979-985
29. Sirri V, Pession A, Trerè D, Montanaro L, Derenzini M (1995) Proportionally constant quantitative transmission of nucleolin and protein B23 in cycling cancer cells. J Clin Pathol 48: M264-268
30. Smith PJ, Skilbeck N, Harrison A, Brocker J (1988) The effect of a series of fixatives on the AgNOR technique. J Pathol 155: 109-112
31. Tötsch M, Öfner D, Maier H, Watzka SBC, Salzer M, Schmid KW (1995) Argyrophilic nucleolar organizer region associated proteins (AgNORs) in adenocarcinomas and squamous cell carcinomas of the lung - correlation with tumor stage and long-term survival. Pathol Res Pract 191:800
32. Trerè D, Pession A, Derenzini M (1989) The silver-stained proteins of interphasic nucleolar organizer regions us a parameter of cell duplication rate. Exp Cell Res 184:131-137